KEGG ENZYME: 3.4.22.57

ENZYME: 3.4.22.57

Entry

EC 3.4.22.57                Enzyme

Name

caspase-4;
ICErelII;
ICErel-II;
Ich-2;
transcript X;
TX;
TX protease;
caspase 4;
CASP-4

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp! but also cleaves at Asp-Glu-Val-Asp!

Comment

This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [3,5,6]. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but, unlike caspase-1, it is very inefficient at generating mature interleukin-1beta (IL-1beta) from pro-IL-1beta [1,4]. Both this enzyme and caspase-5 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17) [3]. The caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO can also inhibit this enzyme, but more slowly [4]. Belongs in peptidase family C14.

History

EC 3.4.22.57 created 2007

Orthology

K04394

caspase 4

Genes

HSA:	837(CASP4)

PTR:	451518(CASP4)

PPS:

100991353

GGO:	101139012 101139367

PON:

100436933

NLE:	100587427(CASP4)

HMH:

116476873

MCC:	704864(CASP4)

MCF:	102116921(CASP4)

MTHB:

126936246

MNI:

105493691

CSAB:

103248367(CASP4)

CATY:

105588758(CASP4)

PANU:

101005674

TGE:

112605779

MLEU:

105534144

RRO:	104665269(CASP4)

RBB:

108513171

TFN:

117080360

PTEH:

111540081

CANG:

105500954(CASP4)

CJC:

100385257

SBQ:

101048389

CIMI:

108315451

CSYR:

103267241 103267244

MMUR:

105862461 105862471

LCAT:

123641867 123641987

PCOQ:

105822166 105822168(CASP5)

OGA:	100953733 105888133(CASP4)

MMU:	12363(Casp4)

MCAL:

110301962

MPAH:

110328019(Casp4)

RNO:	114555(Casp4)

MCOC:

116072580(Casp4)

ANU:	117699797(Casp4)

NGI:	103743234(Casp4)

HGL:	101700797(Casp4)

CPOC:

100731032

CCAN:

109694936

DORD:

105980799(Casp5)

PLOP:

125349534

NCAR:

124960571 124960664

MMMA:

107145708 107145896

OCU:

100359184

OPI:	101530447 101530693

TUP:	102468460 102489894(CASP4)

GVR:

103595948

CFA:	403724(CASP4)

CLUD:

112671423(CASP4)

VVP:

112925945

VLG:

121501029

NPO:

129496568

AML:

100464921

UMR:

103662442

UAH:

113260124

UAR:

123792513

ELK:

111153907

LLV:

125078537

MPUF:

101686692

MNP:

132029007

MLK:

131834822

NVS:

122912246

ORO:

101382016

EJU:

114211414

ZCA:

113913479

MLX:

118013165

NSU:

110586195

LWW:	102743984(CASP4)

FCA:	493961(CASP4)

PYU:	121020795(CASP4)

PCOO:

112866024

PBG:

122482901

PVIV:

125177253

LRUF:

124505860

PTG:

102967742

PPAD:

109258467

PUC:

125910505

AJU:

106976501

HHV:

120246763

BTA:	338039(CASP4)

BOM:	102272500(CASP1)

BIU:

109569831

BBUB:

102394992

BBIS:

104983676

CHX:

102191717

OAS:

101117272

BTAX:

128060611

ODA:

120876144

CCAD:

122449950

MBEZ:

129554237

SSC:

100522887

CFR:

116656626

CBAI:

105067588

CDK:

105100419

VPC:

102540860

BACU:

103012084

BMUS:

118899368

LVE:

103078575

OOR:

101290090

DLE:

111167555

PCAD:

102987795

PSIU:

116757817(CASP4)

NASI:

112415742

ECB:	100069303(CASP4) 100069322

EPZ:	103559837 103559840

EAI:	106837655(CASP4) 106837665

MYB:	102257847 102260720 106726136 106726185

MYD:

102769995

MMYO:

118664119 118664385 118664387

MLF:	102423287 102430359 102430672 102430997

PKL:	118712751 118713780

EFUS:

103299257 103303785 114227918

MNA:

107532382

DRO:	112314268 112314306 112314322

SHON:

118988282

AJM:	119060734 119060770 119060787

PDIC:

114498810 114499617(CASP4) 114499889

PHAS:

123818755 123819792 123819902

MMF:	118627675 118628466 118628467

PPAM:

129086065 129086111

HAI:	109377696 109377700

RFQ:	117029841 117030503

PALE:

102887403 102895641

PGIG:

120599660 120599679

PVP:	105297443 105297474

RAY:	107504289 107504294

MJV:	108385984(CASP1) 118966797

TOD:	119242137 119242138 119242139

SARA:

105942813

LAV:

100661933

TMU:	101352905 101353422 101353932

ETF:

101653056

DNM:	101418845(CASP4) 101425305

MDO:

100032600

GAS:

123239006

SHR:	100914126 100914382

AFZ:	127554936 127554937 127554939 127554940

PCW:	110215002 110215005

PRET:

103474727

LCF:

108900839

ARUT:

117413658 117962789

CCRN:

123294631

» show all

Reference

1 [PMID:7743998]

Authors

Faucheu C, Diu A, Chan AW, Blanchet AM, Miossec C, Herve F, Collard-Dutilleul V, Gu Y, Aldape RA, Lippke JA, et al.

Title

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

Journal

EMBO J 14:1914-22 (1995)
DOI:10.1002/j.1460-2075.1995.tb07183.x

Sequence

[hsa:837]

Reference

2 [PMID:7797510]

Authors

Kamens J, Paskind M, Hugunin M, Talanian RV, Allen H, Banach D, Bump N, Hackett M, Johnston CG, Li P, et al.

Title

Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.

Journal

J Biol Chem 270:15250-6 (1995)
DOI:10.1074/jbc.270.25.15250

Sequence

[hsa:837]

Reference

3 [PMID:16465268]

Authors

Kamada S, Funahashi Y, Tsujimoto Y

Title

Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.

Journal

Cell Death Differ 4:473-8 (1997)
DOI:10.1038/sj.cdd.4400268

Reference

4 [PMID:9578463]

Authors

Fassy F, Krebs O, Rey H, Komara B, Gillard C, Capdevila C, Yea C, Faucheu C, Blanchet AM, Miossec C, Diu-Hercend A.

Title

Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme.

Journal

Eur J Biochem 253:76-83 (1998)
DOI:10.1046/j.1432-1327.1998.2530076.x

Reference

5 [PMID:15163405]

Authors

Martinon F, Tschopp J

Title

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.

Journal

Cell 117:561-74 (2004)
DOI:10.1016/j.cell.2004.05.004

Reference

6 [PMID:11104820]

Authors

Chang HY, Yang X.

Title

Proteases for cell suicide: functions and regulation of caspases.

Journal

Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.57

IUBMB Enzyme Nomenclature:

3.4.22.57

ExPASy - ENZYME nomenclature database:

3.4.22.57

BRENDA, the Enzyme Database:

3.4.22.57

CAS:	182762-08-9

All links

Gene (208)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (195)   
   KEGG MGENES (6)   
   RefGene (6)   
Protein sequence (32)   
   UniProt (3)   
   SWISS-PROT (2)   
   RefSeq(pep) (3)   
   PDBSTR (24)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
3D Structure (7)   
   PDB (7)   
Protein domain (9)   
   InterPro (9)   
All databases (259)   

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