KEGG ENZYME: 3.4.22.64

ENZYME: 3.4.22.64

Entry

EC 3.4.22.64                Enzyme

Name

caspase-11;
CASP-11

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp!

Comment

This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide [1]. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions [1,2]. Belongs in peptidase family C14.

History

EC 3.4.22.64 created 2007

Orthology

K04394

caspase 4

Genes

HSA:	837(CASP4)

PTR:	451518(CASP4)

PPS:

100991353

GGO:	101139012 101139367

PON:

100436933

NLE:	100587427(CASP4)

HMH:

116476873

MCC:	704864(CASP4)

MCF:	102116921(CASP4)

MTHB:

126936246

MNI:

105493691

CSAB:

103248367(CASP4)

CATY:

105588758(CASP4)

PANU:

101005674

TGE:

112605779

MLEU:

105534144

RRO:	104665269(CASP4)

RBB:

108513171

TFN:

117080360

PTEH:

111540081

CANG:

105500954(CASP4)

CJC:

100385257

SBQ:

101048389

CIMI:

108315451

CSYR:

103267241 103267244

MMUR:

105862461 105862471

LCAT:

123641867 123641987

PCOQ:

105822166 105822168(CASP5)

OGA:	100953733 105888133(CASP4)

MMU:	12363(Casp4)

MCAL:

110301962

MPAH:

110328019(Casp4)

RNO:	114555(Casp4)

MCOC:

116072580(Casp4)

ANU:	117699797(Casp4)

NGI:	103743234(Casp4)

HGL:	101700797(Casp4)

CPOC:

100731032

CCAN:

109694936

DORD:

105980799(Casp5)

PLOP:

125349534

NCAR:

124960571 124960664

MMMA:

107145708 107145896

OCU:

100359184

OPI:	101530447 101530693

TUP:	102468460 102489894(CASP4)

GVR:

103595948

CFA:	403724(CASP4)

CLUD:

112671423(CASP4)

VVP:

112925945

VLG:

121501029

NPO:

129496568

AML:

100464921

UMR:

103662442

UAH:

113260124

UAR:

123792513

ELK:

111153907

LLV:

125078537

MPUF:

101686692

MNP:

132029007

MLK:

131834822

NVS:

122912246

ORO:

101382016

EJU:

114211414

ZCA:

113913479

MLX:

118013165

NSU:

110586195

LWW:	102743984(CASP4)

FCA:	493961(CASP4)

PYU:	121020795(CASP4)

PCOO:

112866024

PBG:

122482901

PVIV:

125177253

LRUF:

124505860

PTG:

102967742

PPAD:

109258467

PUC:

125910505

AJU:

106976501

HHV:

120246763

BTA:	338039(CASP4)

BOM:	102272500(CASP1)

BIU:

109569831

BBUB:

102394992

BBIS:

104983676

CHX:

102191717

OAS:

101117272

BTAX:

128060611

ODA:

120876144

CCAD:

122449950

MBEZ:

129554237

SSC:

100522887

CFR:

116656626

CBAI:

105067588

CDK:

105100419

VPC:

102540860

BACU:

103012084

BMUS:

118899368

LVE:

103078575

OOR:

101290090

DLE:

111167555

PCAD:

102987795

PSIU:

116757817(CASP4)

NASI:

112415742

ECB:	100069303(CASP4) 100069322

EPZ:	103559837 103559840

EAI:	106837655(CASP4) 106837665

MYB:	102257847 102260720 106726136 106726185

MYD:

102769995

MMYO:

118664119 118664385 118664387

MLF:	102423287 102430359 102430672 102430997

PKL:	118712751 118713780

EFUS:

103299257 103303785 114227918

MNA:

107532382

DRO:	112314268 112314306 112314322

SHON:

118988282

AJM:	119060734 119060770 119060787

PDIC:

114498810 114499617(CASP4) 114499889

PHAS:

123818755 123819792 123819902

MMF:	118627675 118628466 118628467

PPAM:

129086065 129086111

HAI:	109377696 109377700

RFQ:	117029841 117030503

PALE:

102887403 102895641

PGIG:

120599660 120599679

PVP:	105297443 105297474

RAY:	107504289 107504294

MJV:	108385984(CASP1) 118966797

TOD:	119242137 119242138 119242139

SARA:

105942813

LAV:

100661933

TMU:	101352905 101353422 101353932

ETF:

101653056

DNM:	101418845(CASP4) 101425305

MDO:

100032600

GAS:

123239006

SHR:	100914126 100914382

AFZ:	127554936 127554937 127554939 127554940

PCW:	110215002 110215005

PRET:

103474727

LCF:

108900839

ARUT:

117413658 117962789

CCRN:

123294631

» show all

Reference

1 [PMID:10791975]

Authors

Kang SJ, Wang S, Hara H, Peterson EP, Namura S, Amin-Hanjani S, Huang Z, Srinivasan A, Tomaselli KJ, Thornberry NA, Moskowitz MA, Yuan J.

Title

Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.

Journal

J Cell Biol 149:613-22 (2000)
DOI:10.1083/jcb.149.3.613

Reference

2 [PMID:11684090]

Authors

Hur J, Kim SY, Kim H, Cha S, Lee MS, Suk K.

Title

Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway.

Journal

FEBS Lett 507:157-62 (2001)
DOI:10.1016/S0014-5793(01)02975-1

Sequence

[rno:114555]

Reference

3 [PMID:9491891]

Authors

Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J

Title

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

Journal

Cell 92:501-9 (1998)
DOI:10.1016/S0092-8674(00)80943-5

Sequence

[mmu:12363]

Reference

4 [PMID:16670335]

Authors

Endo M, Mori M, Akira S, Gotoh T.

Title

C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.

Journal

J Immunol 176:6245-53 (2006)
DOI:10.4049/jimmunol.176.10.6245

Sequence

[mmu:12363]

Reference

5 [PMID:11104820]

Authors

Chang HY, Yang X.

Title

Proteases for cell suicide: functions and regulation of caspases.

Journal

Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.64

IUBMB Enzyme Nomenclature:

3.4.22.64

ExPASy - ENZYME nomenclature database:

3.4.22.64

BRENDA, the Enzyme Database:

3.4.22.64

All links

Gene (208)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (195)   
   KEGG MGENES (6)   
   RefGene (6)   
Protein sequence (78)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
   PDBSTR (68)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
3D Structure (5)   
   PDB (5)   
Protein domain (9)   
   InterPro (9)   
All databases (307)   

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