KEGG   ENZYME: 3.4.23.34
Entry
EC 3.4.23.34                Enzyme                                 
Name
cathepsin E;
slow-moving proteinase;
erythrocyte membrane aspartic proteinase;
SMP;
EMAP;
non-pepsin proteinase;
cathepsin D-like acid proteinase;
cathepsin E-like acid proteinase;
cathepsin D-type proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Similar to cathepsin D, but slightly broader specificity
Comment
Found in stomach, spleen, erythrocyte membrane; not lysosomal. Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomer. In peptidase family A1 (pepsin A family)
History
EC 3.4.23.34 created 1992
Orthology
K01382  cathepsin E
Genes
HSA1510(CTSE)
PTR457677(CTSE)
PPS100996015(CTSE)
GGO101124402(CTSE)
PON100452388(CTSE)
NLE100603573(CTSE)
HMH116457406(CTSE)
MCC696202(CTSE)
MCF102122689(CTSE)
MTHB126939097
MNI105484834(CTSE)
CSAB103230206(CTSE)
CATY105576555(CTSE)
PANU101000674(CTSE)
TGE112630667(CTSE)
MLEU105547028(CTSE)
RRO104661729(CTSE)
RBB108535115(CTSE)
TFN117075558(CTSE)
PTEH111522740(CTSE)
CANG105523007(CTSE)
CJC100413525(CTSE)
SBQ101046996(CTSE)
CIMI108302071(CTSE)
CSYR103256047(CTSE)
MMUR105869296(CTSE)
LCAT123627122(CTSE)
PCOQ105821191(CTSE)
OGA100951990(CTSE)
MMU13034(Ctse)
MCAL110297944(Ctse)
MPAH110322114(Ctse)
RNO25424(Ctse)
MCOC116098912(Ctse)
ANU117716318(Ctse)
MUN110541651(Ctse)
CGE100757212(Ctse)
MAUA101824719(Ctse)
PROB127236431(Ctse)
PLEU114698041(Ctse)
MORG121446360(Ctse)
MFOT126505035
AAMP119827852(Ctse)
NGI103725942(Ctse)
HGL101699894(Ctse)
CPOC100135509(Ctse)
CCAN109697219(Ctse)
DORD105986454(Ctse)
DSP122109754(Ctse)
PLOP125359752(Ctse)
NCAR124961986
MMMA107140614(Ctse)
OCU100009063(CTSE)
OPI101529836(CTSE)
TUP102483572(CTSE)
GVR103596736(CTSE)
CFA488577(CTSE)
CLUD112643200(CTSE)
VVP112914539(CTSE)
VLG121471747(CTSE)
NPO129515251(CTSE)
AML100475014(CTSE)
UMR103671000(CTSE)
UAH113242470(CTSE)
UAR123785666(CTSE)
ELK111151129
LLV125086428
MPUF101675517(CTSE)
MNP132025673(CTSE)
MLK131814902(CTSE)
NVS122918855(CTSE)
ORO101364641(CTSE)
EJU114222020(CTSE)
ZCA113933298(CTSE)
MLX118013666(CTSE)
NSU110577337(CTSE)
LWW102747303(CTSE)
FCA101088455(CTSE)
PYU121021633(CTSE)
PCOO112857896(CTSE)
PBG122476515(CTSE)
LRUF124509970
PTG102960694(CTSE)
PPAD109257566(CTSE)
PUC125925480
AJU106972890
HHV120228843(CTSE)
BOM106701532(CTSE)
OOR105748678(CTSE)
DLE111184605(CTSE)
PCAD112067583(CTSE)
PSIU116740615(CTSE)
NASI112403449(CTSE)
ECB100055161(CTSE)
EPZ103553838(CTSE)
EAI106823465(CTSE)
MYB102250825(CTSE)
MYD102753719(CTSE)
MMYO118673642(CTSE)
MLF102426302(CTSE)
MNA107539403(CTSE)
PKL118721390(CTSE)
EFUS103297485(CTSE)
HAI109386433(CTSE)
DRO112315908(CTSE)
SHON119001663(CTSE)
AJM119056851(CTSE)
PDIC114511999(CTSE)
PHAS123820623(CTSE)
MMF118637451(CTSE)
RFQ117014338(CTSE)
PPAM129062038(CTSE)
PALE102890366(CTSE)
PGIG120618005(CTSE)
PVP105300736(CTSE)
RAY107508871(CTSE)
MJV108390208(CTSE)
TOD119233746(CTSE)
SARA101543037(CTSE)
LAV100663037(CTSE)
TMU101345963
ETF101646648(CTSE)
DNM101428239(CTSE)
MDO100019361(CTSE)
GAS123255239
SHR100934264(CTSE)
AFZ127562637
PCW110219635(CTSE)
OAA100081153
GGA417848(CTSEAL) 771791(CTSE)
PCOC116226586 116237013(CTSE)
MGP100548063(CTSE) 100548118
CJO107310248 107324888(CTSE)
TPAI128073778 128088128(CTSE)
LMUT125684183(CTSE) 125700036
NMEL110388319(CTSE) 110392329
APLA101789387(CTSE) 101804173
ACYG106041279(CTSE) 106045567
CATA118246864 118255361(CTSE)
AFUL116498826(CTSE) 116501842
TGU100218931 100228499(CTSE)
LSR110473079(CTSE) 110477989
SCAN103813448 103822388(CTSE)
PMOA120497642(CTSE) 120499781
OTC121339446 121345607(CTSE)
PRUF121349772(CTSE) 121352500
GFR102041269 102043260(CTSE)
FAB101814202 101815239(CTSE)
OMA130248380 130263565(CTSE)
PHI102101700 102104842(CTSE)
PMAJ107205210 107214812(CTSE)
CCAE111932764 111939682(CTSE)
CCW104692361(CTSE) 104698380
CBRC103614888 103625402(CTSE)
ETL114062146 114066524(CTSE)
ZAB102065260 102068482(CTSE)
ACHL103797066 103804906(CTSE)
SVG106850998(CTSE) 106855233
MMEA130580271 130585760(CTSE)
HRT120752038 120762789(CTSE)
FPG101920453(CTSE) 101923255
FCH102049037 102051110(CTSE)
CLV102089416(CTSE) 102097331
EGZ104132915 104134468(CTSE)
NNI104010999 104013197(CTSE)
PCRI104028292 104035282(CTSE)
PLET104619697 104627629(CTSE)
EHS104508279(CTSE) 104510587
PCAO104049636 104052363(CTSE)
ACUN113488852(CTSE) 113491191
TALA104357104(CTSE) 104362117
PADL103919789(CTSE) 103919953
AFOR103893593(CTSE) 103893920
ACHC115335070(CTSE) 115336252
HALD104317214(CTSE) 104320136
HLE104828230 104839555(CTSE)
AGEN126034397 126052105
GCL127026171 127026790
CCRI104158712 104166996(CTSE)
CSTI104559510(CTSE) 104563394
CMAC104476355 104482776(CTSE)
MUI104546268(CTSE) 104546523
BREG104634693(CTSE) 104636840
FGA104078964 104082284(CTSE)
GSTE104253533(CTSE) 104263294
LDI104340856 104343565(CTSE)
MNB103775751(CTSE) 103777806
OHA104326761 104338924(CTSE)
NNT104403415 104404306(CTSE)
SHAB115602365(CTSE) 115604680
DPUB104304783(CTSE) 104305539
PGUU104463627(CTSE) 104470968
ACAR104528006(CTSE) 104532132
CPEA104388640(CTSE) 104388806
AVIT104278738 104280682(CTSE)
CVF104288913 104289344(CTSE)
RTD128900284(CTSE) 128904079
CUCA104061887(CTSE) 104063965
TEO104372448(CTSE) 104382090
BRHI104490508(CTSE) 104499469
AAM106484553(CTSE) 106488475
AROW112964099 112971622(CTSE)
NPD112944636(CTSE) 112958853
TGT104566454(CTSE) 104570266
DNE112983336 112990348(CTSE)
SCAM104140686 104142395(CTSE)
ASN102380654 102384944(CTSE)
AMJ102566566(NOTS) 102567770(CTSE)
CPOO109315502 109317695(CTSE)
GGN109295252(CTSE) 109295724
PSS102461548 102463529(CTSE)
CMY102931323(CTSE) 102933016
CCAY125624957(CTSE) 125630200
DCC119846487(CTSE) 119856970
CPIC101933009(CTSE) 101941871
TST117876457(CTSE) 117877791
CABI116832075(CTSE) 116834455
MRV120387307 120404474(CTSE)
ACS100557309 100561705(ctse) 100561900
ASAO132773612 132773613 132775381
PVT110081416(CTSE)
SUND121928967(CTSE) 121931278
PBI103065297 103067272(CTSE)
PMUR107283823 107292374(CTSE)
CTIG120308438 120320051(CTSE)
TSR106539374(CTSE) 106540835
PGUT117655523 117664384(CTSE)
APRI131201978
PTEX113435697 113446101(CTSE)
NSS113412256 113418158(CTSE)
VKO123033306 123034217(CTSE)
PMUA114590067 114599920(CTSE) 114605772
PRAF128416127(CTSE) 128421636
ZVI118089386(CTSE) 118091055
HCG128323972(CTSE) 128327521
GJA107105702 107115330(CTSE)
STOW125433376(CTSE)
EMC129330675(CTSE) 129335331
XLA108712486 373572(ctse.L) 373573(ctse.S)
XTR100145572(ctse) 100493461
NPR108787647(CTSE) 108804543
RTEM120927148(CTSE) 120930385
BBUF120980617 120993317(CTSE)
BGAR122925799 122933450(CTSE)
MUO115477404 115482228(CTSE)
GSH117347862(CTSE) 117364069
DRE114367(nots)
SRX107725781
SANH107677818
SGH107569115
CCAR109062605
CAUA113066553
CGIB127956167
PTET122343045
OMC131538898(nots)
PPRM120480194
RKG130070422(nots)
MAMB125246313(nots)
CIDE127511203
MASI127435341
TROS130547555(nots)
TDW130420436(nots)
MANU129432324(nots)
IPU108279983(nots)
IFU128623500(nots)
PHYP113531975
SMEO124401120(nots)
TFD113645810(nots)
TVC132859039(nots)
AMEX103036771
CMAO118812424(nots)
EEE113573545
CHAR105892403(nots)
TRU777958(nts)
TFS130519271(nots)
TNGGSTEN00004063G001
LCO104935800
NCC104947164
TBEN117487117(nots)
CGOB115005988 115005990
PGEO117440771(nots)
ELY117249457(nots)
EFO125883124(nots)
PLEP121961372(nots)
SLUC116052020(nots)
ESP116672897
PFLV114550096
GAT120815261(nots)
PPUG119210951(nots)
AFB129112426(nots)
CLUM117726321(nots)
MSAM119895273(nots)
SCHU122870954(nots)
CUD121505784(nots)
ALAT119032520(nots)
MZE101475107
ONL100700379
OAU116318224(nots)
OLA101159061
OML112155171(nots)
XMA102238257
XCO114160681
XHE116737075
PRET103459337
PFOR103154275
PLAI106961768
PMEI106917304
GAF122826528(nots)
PPRL129352857(nots)
CVG107089060
CTUL119796575(nots)
GMU124883378(nots)
NFU107387581
KMR108250475(nots)
ALIM106532841
NWH119428105(nots)
AOCE111569281
MCEP125000247(notS)
CSEM103383134 103384628
POV109644666 109647025
SSEN122761390 122767242
HHIP117757039(nots)
HSP118101601(nots)
LCF108901352
SDU111224749
SLAL111664974
XGL120802483(nots)
HCQ109532693
SSCV125991976
SBIA133493321(nots)
PEE133397485(nots)
PTAO133471636(nots)
BPEC110161516
MALB109967703
BSPL114862529(nots)
SJO128385152(nots)
SASA106576650
STRU115189933 115189939
OTW112238804 121844344
OMY110499710 118938828
OGO124019765
OKI109879517 109884573
OKE118383310(nots)
SNH120032108(nots)
CCLU121553548(nots)
ELS105023104
SFM108936584
PKI111843136 111851189
AANG118219028(nots)
LOC102685181(ctse) 102693226
PSPA121299842 121299843 121299844 121317969(nots) 121319148
ARUT117396772 117415061(nots) 117419715 117435600
PSEX120536437 120539087(nots)
LCM102345230(CTSE) 102354975
CMK103185314(nots)
RTP109925993 109929492
CPLA122559769 122563101
HOC132825046 132828094
LERI129706423 129708909
DER6555650
DSIDsimw501_GD29212(Dsim_GD29212)
DPO6902149
CNS116340310 116348307
MQU128982545
CSEC111873772
PPOI119093579
NAINECAME_03267
OSN115230038
OVIT265_01716 T265_11831
CSLCOCSUDRAFT_55151 COCSUDRAFT_62232 COCSUDRAFT_66898
CTENCANTEDRAFT_113597
YLIYALI0D02024g
SLBAWJ20_1217(PEP4)
CTHRCTHT_0013610
NHENECHADRAFT_101400
CMTCCM_00473
PFYPFICI_13644
ALUCAKAW2_12041S
TMFEYB26_002286
PNOSNOG_05297
FFUCLAFUR5_06056
CNECNC04480 CNF01040
CNBCNBC2690 CNBF3670
CNGCNAG_05869 CNAG_07520
CGICGB_C6590C
CDEUCNBG_1675 CNBG_3484
CCACCcaHIS019_0107290(CcaverHIS019_0107290) CcaHIS019_0500840(CcaverHIS019_0500840) CcaHIS019_0500910(CcaverHIS019_0500910) CcaHIS019_0601270(CcaverHIS019_0601270)
PPLPOSPLDRAFT_104081 POSPLDRAFT_104985
TVSTRAVEDRAFT_124687 TRAVEDRAFT_37373 TRAVEDRAFT_40186 TRAVEDRAFT_43716 TRAVEDRAFT_54018
DSQDICSQDRAFT_49340 DICSQDRAFT_52871 DICSQDRAFT_89467
PCOPHACADRAFT_197031 PHACADRAFT_203593 PHACADRAFT_247956 PHACADRAFT_248326 PHACADRAFT_80588 PHACADRAFT_83207
SHSSTEHIDRAFT_117825 STEHIDRAFT_146264 STEHIDRAFT_96294
HIRHETIRDRAFT_99524
PSQPUNSTDRAFT_116452 PUNSTDRAFT_63287
ADLAURDEDRAFT_114231 AURDEDRAFT_169434 AURDEDRAFT_170430 AURDEDRAFT_186499 AURDEDRAFT_63677
RSXRhiXN_08361
LBCLACBIDRAFT_254624 LACBIDRAFT_310997(LbPR_A3)
MRRMoror_14679
MOREE1B28_000213 E1B28_000766
CPUTCONPUDRAFT_151723
SLASERLADRAFT_418893
PGRPGTG_06539
PTRCPtA15_4A360 PtA15_8A639 PtA15_9A326
PSTRPst134EA_015483 Pst134EA_015493
MLRMELLADRAFT_123288 MELLADRAFT_65252
PTMGSPATT00010671001 GSPATT00012501001 GSPATT00016271001 GSPATT00019552001
SMINv1.2.003841.t1(symbB.v1.2.003841.t1) v1.2.015387.t1(symbB.v1.2.015387.t1) v1.2.018093.t1(symbB.v1.2.018093.t1) v1.2.018143.t1(symbB.v1.2.018143.t1) v1.2.018682.t1(symbB.v1.2.018682.t1) v1.2.018682.t2(symbB.v1.2.018682.t2) v1.2.022081.t1(symbB.v1.2.022081.t1) v1.2.024260.t1(symbB.v1.2.024260.t1) v1.2.037886.t1(symbB.v1.2.037886.t1)
PIFPITG_04975
PSOJPHYSODRAFT_324695
SPARSPRG_05634 SPRG_15475
 » show all
Reference
1  [PMID:3741628]
  Authors
Lapresle C, Puizdar V, Porchon-Bertolotto C, Joukoff E, Turk V.
  Title
Structural differences between rabbit cathepsin E and cathepsin D.
  Journal
Biol Chem Hoppe Seyler 367:523-6 (1986)
DOI:10.1515/bchm3.1986.367.1.523
Reference
2  [PMID:3058036]
  Authors
Yonezawa S, Fujii K, Maejima Y, Tamoto K, Mori Y, Muto N.
  Title
Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form.
  Journal
Arch Biochem Biophys 267:176-83 (1988)
DOI:10.1016/0003-9861(88)90021-5
Reference
3  [PMID:3058118]
  Authors
Jupp RA, Richards AD, Kay J, Dunn BM, Wyckoff JB, Samloff IM, Yamamoto K.
  Title
Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.
  Journal
Biochem J 254:895-8 (1988)
DOI:10.1042/bj2540895
Reference
4  [PMID:2674141]
  Authors
Azuma T, Pals G, Mohandas TK, Couvreur JM, Taggart RT
  Title
Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases.
  Journal
J Biol Chem 264:16748-53 (1989)
  Sequence
[hsa:1510]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.34
IUBMB Enzyme Nomenclature: 3.4.23.34
ExPASy - ENZYME nomenclature database: 3.4.23.34
BRENDA, the Enzyme Database: 3.4.23.34
CAS: 110910-42-4

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