KEGG   ENZYME: 3.4.23.39
Entry
EC 3.4.23.39                Enzyme                                 
Name
plasmepsin II;
aspartic hemoglobinase II;
PFAPD
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr [3]
Comment
Known from the malaria organism, Plasmodium. About 37 kDa. In peptidase family A1 (pepsin A family), and is 73% identical in sequence to plasmepsin I. Inhibited by pepstatin. Formerly included in EC 3.4.23.6
History
EC 3.4.23.39 created 1995
Orthology
K06008  plasmepsin II
Genes
PFA: PF3D7_1408000
PFH: PFHG_00465
PREI: PRSY57_1407300
PGAB: PGSY75_1408000
Reference
1  [PMID:7935597]
  Authors
Dame JB, Reddy GR, Yowell CA, Dunn BM, Kay J, Berry C
  Title
Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum.
  Journal
Mol Biochem Parasitol 64:177-90 (1994)
DOI:10.1016/0166-6851(94)90024-8
  Sequence
[pfa:PF3D7_1408000]
Reference
2  [PMID:8163662]
  Authors
Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE.
  Title
Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway.
  Journal
J Clin Invest 93:1602-8 (1994)
DOI:10.1172/JCI117140
Reference
3  [PMID:7925966]
  Authors
Hill J, Tyas L, Phylip LH, Kay J, Dunn BM, Berry C.
  Title
High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum.
  Journal
FEBS Lett 352:155-8 (1994)
DOI:10.1016/0014-5793(94)00940-6
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.39
IUBMB Enzyme Nomenclature: 3.4.23.39
ExPASy - ENZYME nomenclature database: 3.4.23.39
BRENDA, the Enzyme Database: 3.4.23.39
CAS: 159447-18-4

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Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
Protein sequence (79)   
   UniProt (7)   
   SWISS-PROT (6)   
   RefSeq(pep) (1)   
   PDBSTR (62)   
   PMD (3)   
DNA sequence (5)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (1)   
3D Structure (28)   
   PDB (28)   
Protein domain (5)   
   InterPro (5)   
All databases (122)   

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