KEGG   ENZYME: 3.4.24.1
Entry
EC 3.4.24.1                 Enzyme                                 
Name
atrolysin A;
Crotalus atrox metalloendopeptidase a;
hemorrhagic toxin a;
Crotalus atrox alpha-proteinase;
Crotalus atrox proteinase;
bothropasin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of Asn3!Gln, His5!Leu, His10!Leu, Ala14!Leu and Tyr16!Leu in insulin B chain; removes C-terminal Leu from small peptides
Comment
A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins in the venom of western diamondback rattlesnake. The 60 kDa hemorrhagic toxin 1 of Crotalus ruber ruber shows identical specificity [2]. In peptidase family M12 (astacin family). Related metalloendopeptidases from rattlesnake venoms are EC 3.4.24.41 (atrolysin B), EC 3.4.24.42 (atrolysin C), EC 3.4.24.43 (atroxase), EC 3.4.24.44 (atrolysin E), EC 3.4.24.45 (atrolysin F), EC 3.4.24.46 (adamalysin), EC 3.4.24.47 (horrilysin), and EC 3.4.24.48 (ruberlysin)
History
EC 3.4.24.1 created 1972, modified 1986
Reference
1  [PMID:210790]
  Authors
Bjarnason JB, Tu AT.
  Title
Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e.
  Journal
Biochemistry 17:3395-404 (1978)
DOI:10.1021/bi00609a033
Reference
2  [PMID:2949699]
  Authors
Mori N, Nikai T, Sugihara H, Tu AT.
  Title
Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom.
  Journal
Arch Biochem Biophys 253:108-21 (1987)
DOI:10.1016/0003-9861(87)90643-6
Reference
3  [PMID:3060135]
  Authors
Bjarnason JB, Hamilton D, Fox JW.
  Title
Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom.
  Journal
Biol Chem Hoppe Seyler 369 Suppl:121-9 (1988)
Reference
4
  Authors
Bjarnason, J.B. and Fox, J.W.
  Title
Hemorrhagic toxins from snake venoms.
  Journal
J Toxicol Toxin Rev 7:121-209 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.1
IUBMB Enzyme Nomenclature: 3.4.24.1
ExPASy - ENZYME nomenclature database: 3.4.24.1
BRENDA, the Enzyme Database: 3.4.24.1
CAS: 37288-82-7

  All links  
Protein sequence (9)   
   UniProt (5)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (10)   
   RefSeq(nuc) (3)   
   GenBank (4)   
   EMBL (3)   
Protein domain (7)   
   InterPro (7)   
All databases (26)   

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