| Entry |
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| Name |
procollagen C-endopeptidase;
procollagen C-terminal proteinase;
carboxyprocollagen peptidase;
procollagen C-terminal peptidase;
procollagen C-proteinase;
procollagen carboxypeptidase;
procollagen carboxy-terminal proteinase;
procollagen peptidase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Cleavage of the C-terminal propeptide at Ala!Asp in type I and II procollagens and at Arg!Asp in type III
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| Comment |
A 100 kDa endopeptidase the activity of which is increased by Ca2+ and by an enhancer glycoprotein. In peptidase family M12 (astacin family)
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| History |
EC 3.4.24.19 created 1992
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| Orthology |
| K05502 | bone morphogenetic protein 1 |
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| Genes |
| PTEX: | 113445633 113445685 |
| XLA: | 397872(bmp1.L) 399093(bmp1.S) |
| DRE: | 559877(bmp1b) 572452(bmp1a) |
| SRX: | 107710833 107728365 107746216 107758677 |
| SANH: | 107658580 107661342 107678424 107688986 |
| SGH: | 107553124 107558131 107562633 107583398 |
| CAUA: | 113039693 113054539 113054592 113107433 113110278 |
| CGIB: | 127962864 127966608 128018254 128020934 |
| PTET: | 122350078(bmp1a) 122353046(bmp1b) |
| LROH: | 127169954(bmp1a) 127172368(bmp1b) |
| OMC: | 131545377(bmp1a) 131548782(bmp1b) |
| PPRM: | 120472226(bmp1b) 120489014(bmp1a) |
| RKG: | 130078416(bmp1b) 130082081(bmp1a) |
| MAMB: | 125262307(bmp1b) 125280362(bmp1a) |
| CIDE: | 127517082 127520718 |
| MASI: | 127415112 127423956 127432219 |
| TROS: | 130546304(bmp1b) 130567763(bmp1a) |
| TDW: | 130406983(bmp1a) 130411540(bmp1b) |
| MANU: | 129413643(bmp1a) 129446601(bmp1b) |
| IPU: | 108265517(bmp1a) 108276587(bmp1b) |
| IFU: | 128607430(bmp1a) 128620577(bmp1b) |
| PHYP: | 113533637(bmp1) 113544093 |
| SMEO: | 124393991 124399606(bmp1a) |
| TFD: | 113639248 113645712(bmp1a) |
| TVC: | 132853605(bmp1a) 132863522 |
| AMEX: | 103024888 103045069 |
| CMAO: | 118813274(bmp1a) 118824943(bmp1b) |
| CHAR: | 105902772(bmp1a) 105907038 |
| TRU: | 101068949(bmp1) 101072844 |
| TFS: | 130517431 130525420(bmp1a) |
| TNG: | GSTEN00017307G001 GSTEN00020449G001 |
| TBEN: | 117476299 117496873(bmp1a) |
| CGOB: | 115013854 115016494 |
| PGEO: | 117451922(bmp1a) 117455874 |
| GACU: | 117558123 117561017(bmp1a) |
| EMAC: | 134868912 134873860(bmp1a) |
| ELY: | 117252445(bmp1a) 117269816 |
| EFO: | 125890614(bmp1a) 125906171 |
| PLEP: | 121945014(bmp1a) 121959616 |
| SLUC: | 116035078 116053872(bmp1a) |
| ECRA: | 117944235(bmp1a) 117959405 |
| PFLV: | 114555701 114571340 |
| GAT: | 120830810(bmp1a) 120832220 |
| PPUG: | 119224547(bmp1a) 119226498 |
| AFB: | 129100753(bmp1a) 129102150 |
| CLUM: | 117735826(bmp1a) 117740183 |
| PSWI: | 130196425(bmp1a) 130205349 130205684 |
| MSAM: | 119891092(bmp1a) 119914448 |
| SCHU: | 122865346 122876957(bmp1a) |
| CUD: | 121509636(bmp1a) 121525241 |
| ALAT: | 119018975(bmp1a) 119029853 |
| OAU: | 116310222(bmp1a) 116322545 |
| OML: | 112148425(bmp1a) 112163076 |
| CSAI: | 133450350(bmp1a) 133454666 |
| XHE: | 116724780 116729501(bmp1) |
| PRET: | 103470513 103473707 |
| PFOR: | 103145852 103148700 |
| PLAI: | 106938060(bmp1) 106962456 |
| PMEI: | 106914985(bmp1) 106925500 |
| GAF: | 122819389 122827965(bmp1a) |
| PPRL: | 129366463 129372196(bmp1a) |
| CVG: | 107092678 107093872(bmp1) |
| CTUL: | 119783946(bmp1a) 119789025 |
| GMU: | 124873014 124877173(bmp1a) |
| NFU: | 107373116 107393753(bmp1) |
| KMR: | 108232606 108236587(bmp1a) |
| ALIM: | 106514493 106534203 |
| NWH: | 119413999(bmp1a) 119424806 |
| AOCE: | 111567679 111579811 |
| MCEP: | 124997122 125011806(bmp1a) |
| CSEM: | 103390498 103397185 103398239 |
| SSEN: | 122769038(bmp1a) 122781938 |
| HHIP: | 117768039(bmp1a) 117771850 |
| HSP: | 118115130(bmp1a) 118125450 |
| SMAU: | 118284608 118314230(bmp1a) |
| LCF: | 108878376(bmp1a) 108879830 |
| SLAL: | 111645016 111655191 |
| XGL: | 120805554(bmp1a) 120806693 |
| SSCV: | 125980039 125993568 |
| SBIA: | 133490833 133498843(bmp1a) |
| PEE: | 133400023(bmp1a) 133413618 |
| PTAO: | 133475040(bmp1a) 133490064 |
| BPEC: | 110160651 110169815 |
| MALB: | 109956973 109963495 |
| BSPL: | 114863150(bmp1a) 114866769 |
| SJO: | 128364218(bmp1a) 128380562 |
| SASA: | 100380312(bmp1) 106579847 106585594 |
| STRU: | 115149159 115164536 115200112 |
| OTW: | 112248466 112257596 112262929(bmp1a) |
| OMY: | 110525648 110536019(bmp1a) 110537216 |
| OGO: | 123999447 124034333 124036289 |
| ONE: | 115105800 115111587 115140028 |
| OKI: | 109879433 109892542 109895878 |
| OKE: | 118358326 118375825 118393191 |
| SALP: | 111957729 111973946 111981226 |
| SNH: | 120017819 120045043 120063226 |
| CCLU: | 121530881 121573785 121584832 |
| ELS: | 105014263(bmp1) 105014870 |
| PKI: | 111838614(bmp1) 111857333 |
| AANG: | 118213089 118237278(bmp1a) |
| PSPA: | 121302323 121303148 |
| ARUT: | 117397969 117966448 |
| BBEL: | 109471399 109471402 109483296 109485679 |
| SPU: | 100890891 115923379 373360(BMP1) |
| CSCU: | 111613782 111613783 111613784 |
| PDAM: | 113665761 113670912 113678110 113680396 |
| SPIS: | 111322335 111329169 111336059 111338165 111341484 |
| DGT: | 114518341 114521449 114544682 |
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| Reference |
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| Authors |
Hojima Y, van der Rest M, Prockop DJ. |
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| Title |
Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization. |
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| Journal |
J Biol Chem 260:15996-6003 (1985) |
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| Reference |
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| Authors |
Kessler E, Adar R. |
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| Title |
Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.19 |
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