| Entry |
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| Name |
astacin;
Astacus proteinase;
crayfish small-molecule proteinase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'
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| Comment |
A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12.
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| History |
EC 3.4.24.21 created 1972 as EC 3.4.99.6, transferred 1992 to EC 3.4.24.21
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| Orthology |
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| Genes |
| BBEL: | 109464394 109475423 |
| BCOO: | 119066715 119075049 119083350 119084898 |
| PVM: | 113819445 113826330 113826331 113826343 |
| PJA: | 122243963 122244751 122261534 122261535 122261538 122261539 122265394 |
| PCHN: | 125024937 125026426 125026444 125026591 125026592 125027847 125028102 125042080 |
| PMOO: | 119580291 119580292 119580293 119580294 |
| HAME: | 121858615 121870999 121875047 |
| PCLA: | 123766492 123766493 |
| PTRU: | 123498442 123504388 123514655 123514938 |
| HAZT: | 108674308 108678383 108683173 |
| PPOI: | 119091776 119096273 119097442 119097443 119097497 119104572 119105516 119106457 |
| RMP: | 119174309 119174310 119174650 119188285 |
| UDV: | 129220545 129220936 129221480 129222492 129222830 129224644 129229744 |
| SDM: | 118181404 118185926 118188789 118189731 118192937 118192940 118192941 118192942 118192953 118192954 118196588 118199930 118202013 |
| LPOL: | 106459180 106459182 106464641 |
| CEL: | CELE_C26C6.3(nas-36) CELE_C37H5.9(nas-9) CELE_F40E10.1(hch-1) CELE_F42A10.8(nas-28) CELE_F46C5.3(nas-25) CELE_F58A6.4(nas-29) CELE_K04E7.3(nas-33) CELE_K06A4.1(nas-3) CELE_T02B11.7(nas-32) CELE_T04G9.2(nas-15) CELE_T11F9.3(nas-20) CELE_T23F4.4(nas-27) |
| CBR: | CBG_02333(Cbr-nas-29) CBG_03189(Cbr-nas-25) CBG_07102(Cbr-nas-27) CBG_07573(Cbr-hch-1) CBG_08825(Cbr-nas-9) CBG_11886(Cbr-nas-36) CBG_17894(Cbr-nas-32) CBG_21082 CBG_23213 |
| CRQ: | GCK72_000079 GCK72_005609 GCK72_005960 GCK72_008059 GCK72_015340 GCK72_015939 GCK72_016736 GCK72_016739 GCK72_016740 GCK72_016756 GCK72_016757 GCK72_019128 GCK72_019334 GCK72_019669 GCK72_024590 |
| CRG: | 105322333 105323497 105324354 |
| CANU: | 128172579 128186977 |
| OED: | 125647381 125662916 130047327 |
| PMAX: | 117333751 117339095 117344273 |
| ATEN: | 116286289 116287698 116303373 116308601 116308602 116308605 |
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| Reference |
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| Authors |
Krauhs E, Dorsam H, Little M, Zwilling R, Ponstingl H. |
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| Title |
A protease from Astacus fluviatilis as an aid in protein sequencing. |
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| Journal |
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| Reference |
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| Authors |
Titani K, Torff HJ, Hormel S, Kumar S, Walsh KA, Rodl J, Neurath H, Zwilling R. |
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| Title |
Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis. |
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| Journal |
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| Sequence |
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| Reference |
3 |
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| Authors |
Stocker, W., Wolz, R.L., Zwilling, R., Strydom, D.J. and Auld, D.S. |
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| Title |
Astacus protease, a zinc metalloenzyme. |
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| Journal |
Biochemistry 27:5026-5032 (1988) |
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| Reference |
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| Authors |
Stocker W, Ng M, Auld DS |
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| Title |
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.21 |
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