KEGG ENZYME: 3.4.24.23

ENZYME: 3.4.24.23

Entry

EC 3.4.24.23                Enzyme

Name

matrilysin;
matrin;
uterine metalloendopeptidase;
matrix metalloproteinase 7;
putative (or punctuated) metalloproteinase-1;
matrix metalloproteinase pump 1;
MMP 7;
PUMP-1 proteinase;
PUMP;
metalloproteinase pump-1;
putative metalloproteinase;
MMP

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Cleavage of Ala14!Leu and Tyr16!Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I)

Comment

Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll

History

EC 3.4.24.23 created 1992

Orthology

K01397

matrix metalloproteinase-7 (matrilysin, uterine)

Genes

HSA:	4316(MMP7)

PTR:	451509(MMP7)

PPS:	100969359(MMP7)

GGO:	109025397(MMP7)

PON:	100458458(MMP7)

NLE:	100581294(MMP7)

HMH:	116477414(MMP7)

MCC:	703072(MMP7)

MCF:	102139796(MMP7)

MTHB:

126936009

MNI:	105493713(MMP7)

CSAB:

103248342(MMP7)

CATY:

105588780(MMP7)

PANU:

100998570(MMP7)

TGE:	112606453(MMP7)

MLEU:

105542736(MMP7)

RRO:	104674660(MMP7)

RBB:	108514063(MMP7)

TFN:	117080875(MMP7)

PTEH:

111539976(MMP7)

CANG:

105500937(MMP7)

CJC:	100394775(MMP7)

SBQ:	101053487(MMP7)

CIMI:

108315427(MMP7)

CSYR:

103258294(MMP7)

MMUR:

105874595(MMP7)

LCAT:

123641894(MMP7)

PCOQ:

105822224(MMP7)

OGA:	100952024(MMP7)

MMU:	17393(Mmp7)

MCAL:

110302310(Mmp7)

MPAH:

110328502(Mmp7)

RNO:	25335(Mmp7)

MCOC:

116071921(Mmp7)

ANU:	117699911(Mmp7)

MUN:	110553754(Mmp7)

CGE:	100760540(Mmp7)

MAUA:

101835173(Mmp7)

PROB:

127233216(Mmp7)

PLEU:

114708000(Mmp7)

MORG:

121451900(Mmp7)

MFOT:

126513707

AAMP:

119809253(Mmp7)

NGI:	103731642(Mmp7)

HGL:	101718114(Mmp7)

CPOC:

100727130(Mmp7)

CCAN:

109689246(Mmp7)

DORD:

105980726(Mmp7)

DSP:	122110397(Mmp7)

PLOP:

125349683(Mmp7)

NCAR:

124958078

MMMA:

107146003(Mmp7)

OCU:

100357971

OPI:	101526656(MMP7)

TUP:	102492968(MMP7)

GVR:	103596076(MMP7)

CFA:	489432(MMP7)

CLUD:

112671546(MMP7)

VVP:	112925905(MMP7)

VLG:	121500495(MMP7)

NPO:	129496620(MMP7)

AML:	100480431(MMP7)

UMR:	103662460(MMP7)

UAH:	113260140(MMP7)

UAR:	123792350(MMP7)

ELK:

111153696

LLV:

125079421

MPUF:

101691355(MMP7)

MNP:	131998616(MMP7)

MLK:	131834592(MMP7)

NVS:	122913966(MMP7)

ORO:	101373992(MMP7)

EJU:	114211451(MMP7)

ZCA:	113914723(MMP7)

MLX:	118013151(MMP7)

NSU:	110586265(MMP7)

LWW:	102734300(MMP7)

FCA:	727698(MMP7)

PYU:	121020775(MMP7)

PCOO:

112865485(MMP7)

PBG:	122482889(MMP7)

PVIV:

125177168(MMP7)

LRUF:

124506481

PTG:	102971750(MMP7)

PPAD:

109257534(MMP7)

PUC:

125910810

AJU:

106976492

HHV:	120219693(MMP7)

BTA:	286794(MMP7)

BOM:	102286488(MMP7)

BIU:	109569205(MMP7)

BBUB:

102401163(MMP7)

BBIS:

104984388(MMP7)

CHX:	102173210(MMP7)

OAS:	100192317(MMP7)

BTAX:

128060945(MMP7)

ODA:	120876157(MMP7)

CCAD:

122449908(MMP7)

MBEZ:

129553544(MMP7)

SSC:	397411(MMP7)

CFR:	102514476(MMP7)

CBAI:

105067599(MMP7)

CDK:	105087173(MMP7)

VPC:	102529673(MMP7)

BACU:

103008313(MMP7)

BMUS:

118898985(MMP7)

LVE:	103091433(MMP7)

OOR:	101277151(MMP7)

DLE:	111168376(MMP7)

PCAD:

102996958(MMP7)

PSIU:

116758060(MMP7)

NASI:

112409967(MMP7)

ECB:	100068985(MMP7)

EPZ:	103552631(MMP7)

EAI:	106843114(MMP7)

MYB:	102242272(MMP7)

MYD:	102771393(MMP7)

MMYO:

118664466(MMP7)

MLF:	102425259(MMP7)

PKL:	118713472(MMP7)

EFUS:

103293002(MMP7)

MNA:	107532390(MMP7)

DRO:	112317529(MMP7)

SHON:

118975682(MMP7)

AJM:	119054063(MMP7)

PDIC:

114500092(MMP7)

PHAS:

123805486(MMP7)

MMF:	118628230(MMP7)

PPAM:

129085867(MMP7)

RFQ:	117030598(MMP7)

PALE:

102884900(MMP7)

PGIG:

120618081(MMP7)

PVP:

105309856

RAY:	107504637(MMP7)

TOD:	119239983(MMP7) 119240911

SARA:

101553243(MMP7)

LAV:	100655566(MMP7)

TMU:

101346853

DNM:	101410832(MMP7)

MDO:	100012296(MMP7)

GAS:	123239100(MMP26) 123241343(MMP7) 123247659

SHR:	100933647(MMP7)

AFZ:	127546777 127554920 127557437

PCW:	110214975(MMP7)

OAA:	100079035(MMP7)

GGA:	418983(MMP7)

PCOC:

116230602(MMP7)

MGP:	100543554(MMP7)

CJO:	107308406(MMP7)

TPAI:

128074819(MMP7)

LMUT:

125690398(MMP7)

NMEL:

110403948(MMP7)

APLA:

101793749(MMP7)

ACYG:

106034123(MMP7)

CATA:

118245990(MMP7)

AFUL:

116501858(MMP7)

TGU:	100231056(MMP7)

LSR:	110470042(MMP7)

SCAN:

103812521(MMP7)

PMOA:

120506744

OTC:	121342552(MMP7)

PRUF:

121364131

GFR:	102045386 102045552

FAB:	101821768(MMP7)

OMA:	130251174(MMP7)

PHI:	102109334(MMP7)

PMAJ:

107206059(MMP7)

CCAE:

111923545(MMP7)

CCW:	104690112(MMP7)

CBRC:

103617960(MMP7)

ETL:	114067046(MMP7)

ZAB:	102063358(MMP7)

ACHL:

103800148(MMP7)

SVG:	106859386(MMP7)

MMEA:

130576296(MMP7)

HRT:	120748616(MMP7)

FPG:	101913643(MMP10)

FCH:	102052975(MMP7)

CLV:	102097689(MMP7)

EGZ:	104128913(MMP7)

NNI:	104023125(MMP7)

PCRI:

104037822(MMP7)

PLET:

104613723(MMP7)

EHS:	104514434(MMP7)

PCAO:

104049987(MMP7)

ACUN:

113477035(MMP7)

TALA:

104368304(MMP7)

PADL:

103915461(MMP7)

AFOR:

103895118(MMP7)

ACHC:

115353361(MMP7)

HALD:

104314250(MMP7)

HLE:	104828459(MMP7)

AGEN:

126048152

GCL:

127024740

CCRI:

104169313(MMP7)

CSTI:

104558438(MMP7)

CMAC:

104474182(MMP7)

MUI:

104542492

BREG:

104636744(MMP7)

FGA:	104073681(MMP7)

GSTE:

104250728(MMP7)

LDI:	104353339(MMP7)

MNB:	103781299(MMP7)

OHA:	104333058(MMP7)

NNT:	104402867(MMP7)

SHAB:

115604071(MMP7)

DPUB:

104300631(MMP7)

PGUU:

104466851

ACAR:

104517630(MMP7)

CPEA:

104390310(MMP7)

AVIT:

104278189(MMP7)

CVF:	104290324(MMP7)

RTD:	128904209(MMP7)

CUCA:

104055073(MMP7)

TEO:	104375909(MMP7)

BRHI:

104489174(MMP7)

AAM:

106495507

AROW:

112971950(MMP7)

NPD:	112943727(MMP7)

TGT:	104571784(MMP7)

DNE:	112988757(MMP7)

SCAM:

104151763(MMP7)

ASN:	102388711(MMP7)

AMJ:	102564382(MMP7)

CPOO:

109306339(MMP7)

GGN:

109302391

CMY:	102941027(MMP7)

CCAY:

125620779

DCC:	119841925(MMP7)

CPIC:

101948697(MMP7)

TST:	117871176(MMP7)

CABI:

116814908(MMP7)

MRV:	120376056(MMP7)

ACS:	100553635(mmp7) 100553835

ASAO:

132770078 132772201

PVT:	110089076 110089077

SUND:

121924691 121926769 121927245

PBI:	103053231(MMP7) 103055014

PMUR:

107286357 107286358

CTIG:

120297728(MMP7) 120313876 120313884

PGUT:

117660859 117660863

APRI:

131199604 131199621

PTEX:

113440478 113440510

NSS:	113417301 113417307

VKO:	123029184 123029389

PMUA:

114595295 114595296

PRAF:

128412586 128412593

ZVI:	118085168 118085324

HCG:	128351373 128351375

GJA:

107119163

STOW:

125432095

EMC:	129326073 129326304 129326306 129326307 129326308 129326634

XTR:

116408899

NPR:

108786936

PMRN:

116942497

BBEL:

109474420

LSIN:

126971418

HVI:	124361213 124371602

HAZT:

108680386

EAF:

111716797

HRO:	HELRODRAFT_108214 HELRODRAFT_81623

BGT:

106065202

NVE:

5500445

DGT:

114530204

HSY:

130629241

» show all

Reference

1 [PMID:2844164]

Authors

Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R

Title

The collagenase gene family in humans consists of at least four members.

Journal

Biochem J 253:187-92 (1988)
DOI:10.1042/bj2530187

Sequence

[hsa:4319]

Reference

2 [PMID:3182822]

Authors

Woessner JF Jr, Taplin CJ.

Title

Purification and properties of a small latent matrix metalloproteinase of the rat uterus.

Journal

J Biol Chem 263:16918-25 (1988)

Reference

3 [PMID:2550050]

Authors

Quantin B, Murphy G, Breathnach R.

Title

Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members.

Journal

Biochemistry 28:5327-34 (1989)
DOI:10.1021/bi00439a004

Sequence

[hsa:4316]

Reference

4 [PMID:2253219]

Authors

Miyazaki K, Hattori Y, Umenishi F, Yasumitsu H, Umeda M.

Title

Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.

Journal

Cancer Res 50:7758-64 (1990)

Sequence

[hsa:4316]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.23

IUBMB Enzyme Nomenclature:

3.4.24.23

ExPASy - ENZYME nomenclature database:

3.4.24.23

BRENDA, the Enzyme Database:

3.4.24.23

CAS:	141256-52-2

DBGET integrated database retrieval system