KEGG   ENZYME: 3.4.24.24
Entry
EC 3.4.24.24                Enzyme                                 
Name
gelatinase A;
72-kDa gelatinase;
matrix metalloproteinase 2;
type IV collagenase (ambiguous);
3/4 collagenase (obsolete);
matrix metalloproteinase 5 (obsolete);
72 kDa gelatinase type A;
collagenase IV (ambiguous);
collagenase type IV (ambiguous);
MMP 2;
type IV collagen metalloproteinase (ambiguous);
type IV collagenase/gelatinase (ambiguous)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly!Ile-Ala-Gly-Gln
Comment
A secreted endopeptidase in peptidase family M10 (interstitial collagenase family), but possessing an additional fibronectin-like domain
History
EC 3.4.24.24 created 1992
Orthology
K01398  matrix metalloproteinase-2 (gelatinase A)
Genes
HSA4313(MMP2)
PTR454094(MMP2)
PPS100970966(MMP2)
GGO101147102(MMP2)
PON100451667(MMP2)
NLE100597186(MMP2)
HMH116471259(MMP2)
MCC698478(MMP2)
MCF101865544(MMP2)
MTHB126945112
MNI105494081(MMP2)
CSAB103233007(MMP2)
CATY105588567(MMP2)
PANU101014166(MMP2)
TGE112613724(MMP2)
MLEU105533444(MMP2)
RRO104671481(MMP2)
RBB108531264(MMP2)
TFN117087797(MMP2)
PTEH111541252(MMP2)
CJC100387448(MMP2)
SBQ101042210(MMP2)
CIMI108305432(MMP2)
CSYR103272469(MMP2)
MMUR105866549(MMP2)
LCAT123625360(MMP2)
PCOQ105817042(MMP2)
OGA100965003(MMP2)
MMU17390(Mmp2)
MCAL110299708(Mmp2)
MPAH110337240(Mmp2)
RNO81686(Mmp2)
MCOC116069868(Mmp2)
ANU117701832 117723004(Mmp2)
MUN110545189(Mmp2)
CGE100774744(Mmp2)
MAUA101833614(Mmp2)
PROB127230005(Mmp2)
PLEU114694533(Mmp2)
MORG121446989(Mmp2)
MFOT126502468
AAMP119802075(Mmp2)
NGI103731682(Mmp2)
HGL101696977(Mmp2)
CPOC100719361(Mmp2)
CCAN109690723(Mmp2)
DORD105994417(Mmp2)
DSP122116321(Mmp2)
PLOP125358446(Mmp2)
NCAR124967289
MMMA107144864(Mmp2)
OCU100009000(MMP2)
OPI101522382(MMP2)
TUP102483061(MMP2)
GVR103610004 103610353
CFA403733(MMP2)
CLUD112659990(MMP2)
VVP112929621(MMP2)
VLG121498055(MMP2)
NPO129513683(MMP2)
AML100476183(MMP2)
UMR103673901(MMP2)
UAH113252249(MMP2)
UAR123798414(MMP2)
ELK111157340
LLV125089554
MPUF101675156(MMP2)
MNP132004844(MMP2)
MLK131818062(MMP2)
NVS122911443(MMP2)
ORO101378425(MMP2)
EJU114204089(MMP2)
ZCA113936159(MMP2)
MLX118023778(MMP2)
NSU110593361(MMP2)
LWW102726609(MMP2)
FCA101098838(MMP2)
PYU121045318(MMP2)
PCOO112857297(MMP2)
PBG122494216(MMP2)
LRUF124511320
PTG102956398(MMP2)
PPAD109270907(MMP2)
PUC125918162 125918164
AJU106973291
HHV120238088(MMP2)
BTA282872(MMP2)
BOM102269336(MMP2)
BIU109572595(MMP2)
BBUB102401701(MMP2)
BBIS105004336(MMP2)
CHX102184364(MMP2)
OAS443115(MMP2)
BTAX128062791(MMP2)
ODA120873204(MMP2)
CCAD122420084(MMP2)
MBEZ129547097(MMP2)
SSC397391(MMP2)
CFR102521167(MMP2)
CBAI105075731(MMP2)
CDK105097506(MMP2)
VPC102524948(MMP2)
BACU103016736(MMP2)
LVE103071760(MMP2)
OOR101275485(MMP2)
DLE111164984(MMP2)
PCAD102973920(MMP2)
PSIU116743436(MMP2)
NASI112401290(MMP2)
ECB100033948(MMP2)
EPZ103553197(MMP2)
EAI106822484(MMP2)
MYB102260608(MMP2)
MYD102767174(MMP2)
MMYO118674505(MMP2)
MLF102418715(MMP2)
MNA107543503(MMP2)
PKL118720617(MMP2)
EFUS103295886(MMP2)
HAI109383663(MMP2)
DRO112296673(MMP2)
SHON119001111(MMP2)
AJM119046441(MMP2)
PDIC114488295(MMP2)
PHAS123806069(MMP2)
MMF118639416(MMP2)
RFQ117035241(MMP2)
PPAM129068219(MMP2)
PALE102883808(MMP2)
PGIG120617290(MMP2)
PVP105292047(MMP2)
RAY107499669(MMP2)
MJV108387896(MMP2)
TOD119248904(MMP2)
SARA101540694(MMP2)
LAV100659450(MMP2)
TMU101358817
ETF101655753(MMP2)
DNM101442293(MMP2)
MDO100020585(MMP2)
GAS123235296(MMP2)
SHR100935012(MMP2)
AFZ127550719
PCW110207503(MMP2)
OAA100077120(MMP2) 103166153
GGA386583(MMP2)
PCOC116243917(MMP2)
MGP100125331(MMP2)
CJO107319190(MMP2)
TPAI128082236(MMP2)
LMUT125699398(MMP2)
NMEL110404299(MMP2)
APLA101802059(MMP2)
ACYG106043076(MMP2)
CATA118246321(MMP2)
AFUL116493904(MMP2)
TGU100228546(MMP2)
LSR110484414(MMP2)
SCAN103816631(MMP2)
PMOA120508123(MMP2)
OTC121333988(MMP2)
PRUF121348910(MMP2)
GFR102040497(MMP2)
FAB101815345(MMP2)
OMA130257709(MMP2)
PHI102107059(MMP2)
PMAJ107209744(MMP2)
CCAE111934584(MMP2)
CCW104687474(MMP2)
CBRC103620188(MMP2)
ETL114060386(MMP2)
ZAB102062240(MMP2)
SVG106857180(MMP2)
MMEA130572734(MMP2)
HRT120757792(MMP2)
FPG101924896(MMP2)
FCH102056005(MMP2)
CLV102092170(MMP2)
EGZ104125198(MMP2)
NNI104016354(MMP2)
PCRI104033146(MMP2)
PLET104620450(MMP2)
EHS104514040(MMP2)
PCAO104050385(MMP2)
ACUN113484433(MMP2)
TALA104366500(MMP2)
PADL103914183(MMP2)
AFOR103896821(MMP2)
ACHC115346374(MMP2)
HALD104318434(MMP2)
HLE104842482(MMP2)
AGEN126040514
GCL127021340
CCRI104166870(MMP2)
CSTI104554453
CMAC104473655(MMP2)
MUI104537531 104539090
BREG104632882(MMP2)
FGA104082041(MMP2)
GSTE104254084(MMP2)
LDI104344620(MMP2)
MNB103775244(MMP2)
OHA104333942(MMP2)
NNT104409290(MMP2)
SHAB115600940(MMP2) 115619032
DPUB104298994(MMP2)
PGUU104471839(MMP2)
ACAR104531227(MMP2)
CPEA104388562(MMP2)
AVIT104279221(MMP2)
CVF104287626(MMP2)
RTD128908768(MMP2)
CUCA104056804(MMP2)
TEO104371920(MMP2)
BRHI104500759(MMP2)
AAM106483196(MMP2)
AROW112967552(MMP2)
NPD112947679(MMP2)
TGT104568861(MMP2)
DNE112984295(MMP2)
SCAM104146313(MMP2)
ASN102372370(MMP2)
AMJ102562302(MMP2)
CPOO109310506(MMP2)
GGN109289618(MMP2)
PSS102463152(MMP2)
CMY102946066(MMP2)
CCAY125620722(MMP2)
DCC119841114(MMP2)
CPIC101941088(MMP2)
TST117886578(MMP2)
CABI116820815(MMP2)
MRV120384744(MMP2)
ACS100557569(mmp2)
ASAO132782909(MMP2)
PVT110082478(MMP2)
SUND121914771(MMP2)
PBI103055844(MMP2)
PMUR107295718(MMP2)
CTIG120312104(MMP2)
PGUT117670956(MMP2)
APRI131184179(MMP2)
PTEX113444987(MMP2)
NSS113424575(MMP2)
VKO123022290(MMP2)
PMUA114602200(MMP2)
PRAF128419434(MMP2)
ZVI118087109(MMP2)
HCG128334544(MMP2)
GJA107108344(MMP2)
STOW125443647(MMP2)
EMC129343948(MMP2)
XLA380389(mmp2.S)
XTR548506(mmp2)
NPR108797889(MMP2)
RTEM120917452(MMP2)
BBUF120980275(MMP2)
BGAR122920492(MMP2)
MUO115470786(MMP2)
GSH117359456(MMP2)
DRE337179(mmp2)
SRX107713064 107755129
SANH107657110(mmp2) 107696695
SGH107548946 107563472
CAUA113051472 113106043
CGIB127961268 128016865
PTET122348317(mmp2)
LROH127168284(mmp2)
OMC131544644(mmp2)
PPRM120491030(mmp2)
RKG130099619(mmp2)
MAMB125264833(mmp2)
CIDE127515393
MASI127415980 127448392
TROS130558457(mmp2)
TDW130422583(mmp2)
MANU129444626(mmp2)
IPU108259638
IFU128602888(mmp2)
PHYP113540866(mmp2)
SMEO124379903(mmp2)
TFD113636780(mmp2)
TVC132838989(mmp2)
CMAO118817379(mmp2)
EEE113590945(mmp2)
CHAR105899783(mmp2)
TRU653022(mmp2)
TFS130516082(mmp2)
TNGGSTEN00012583G001
LCO104926945(mmp2)
NCC104964801(mmp2)
TBEN117496674(mmp2)
CGOB115028668(mmp2)
PGEO117440927(mmp2)
GACU117549196(mmp2)
ELY117258541(mmp2)
EFO125902484(mmp2)
PLEP121966899(mmp2)
SLUC116037572(mmp2)
ECRA117941776(mmp2)
ESP116689294(mmp2)
PFLV114549991(mmp2)
GAT120833716(mmp2)
PPUG119197235(mmp2)
AFB129099251(mmp2)
CLUM117728779(mmp2)
MSAM119890137(mmp2)
SCHU122877488(mmp2)
CUD121512707(mmp2)
ALAT119018443(mmp2)
MZE101472680(mmp2)
ONL100700606(mmp2)
OAU116325529(mmp2)
OLA100125419(mmp2)
OML112160915(mmp2)
XMA102226344(mmp2)
XCO114142975(mmp2)
XHE116718543(mmp2)
PRET103462668(mmp2)
PFOR103138100(mmp2)
PLAI106948460(mmp2)
PMEI106910952(mmp2)
GAF122840701(mmp2)
PPRL129364147(mmp2)
CVG107095465(mmp2)
CTUL119795137(mmp2)
GMU124867401(mmp2)
NFU107381256(mmp2)
KMR108240277(mmp2)
ALIM106517245(mmp2)
NWH119430131(mmp2)
AOCE111577723(mmp2)
MCEP125005339(mmp2)
CSEM103378988(mmp2)
POV109625153(mmp2)
SSEN122772468(mmp2)
HHIP117757506(mmp2)
HSP118106170(mmp2)
LCF108876984
SDU111218486(mmp2)
SLAL111649502(mmp2)
XGL120801953(mmp2)
HCQ109513920(mmp2)
SSCV125967271
SBIA133498146(mmp2)
PEE133397698(mmp2)
PTAO133474178(mmp2)
BPEC110175240(mmp2)
MALB109955873(mmp2)
BSPL114852189(mmp2)
SJO128358710(mmp2)
SASA100194903(mmp2) 106562416(MMP2)
STRU115167017 115203309
OTW112263861(mmp2)
OMY100135793 110526614
OGO124033574 124035551
ONE115121729(mmp2) 115125488
OKI109878791 109880637
OKE118376062 118381591
SALP112072490 112079849
SNH120025036 120039801
CCLU121580402(mmp2)
ELS105023458(mmp2)
SFM108926353 108928317
PKI111832721(mmp2) 111858175
AANG118215604 118228365
LOC102688130(mmp2)
PSPA121296334 121325662(mmp2)
ARUT117424448 117425416
PSEX120535223(mmp2)
LCM102350008(MMP2)
CMK103176101(mmp2)
RTP109921647(mmp2)
CPLA122558436(mmp2)
HOC132823964(mmp2)
LERI129705052(mmp2)
PMRN116956003 116956005
LRJ133358063(MMP2) 133358065
CIN100181993
SCLV120333349
LSM121123624 121128738
 » show all
Reference
1  [PMID:2994741]
  Authors
Murphy G, McAlpine CG, Poll CT, Reynolds JJ.
  Title
Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen.
  Journal
Biochim Biophys Acta 831:49-58 (1985)
DOI:10.1016/0167-4838(85)90148-7
Reference
2  [PMID:2834383]
  Authors
Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI
  Title
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
  Journal
J Biol Chem 263:6579-87 (1988)
  Sequence
[hsa:4313]
Reference
3  [PMID:2269296]
  Authors
Okada Y, Morodomi T, Enghild JJ, Suzuki K, Yasui A, Nakanishi I, Salvesen G, Nagase H.
  Title
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties.
  Journal
Eur J Biochem 194:721-30 (1990)
DOI:10.1111/j.1432-1033.1990.tb19462.x
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.24
IUBMB Enzyme Nomenclature: 3.4.24.24
ExPASy - ENZYME nomenclature database: 3.4.24.24
BRENDA, the Enzyme Database: 3.4.24.24
CAS: 146480-35-5

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