KEGG   ENZYME: 3.4.24.30
Entry
EC 3.4.24.30                Enzyme                                 
Name
coccolysin;
Streptococcus thermophilus intracellular proteinase;
EM 19000
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Preferential cleavage: !Leu, !Phe, !Tyr, !Ala
Comment
A 30 kDa endopeptidase found intracellularly in S. thermophilus [1] and S. diacetilactis [2] and in the medium of S. faecalis [3,4]. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4
History
EC 3.4.24.30 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.30
Orthology
K08605  coccolysin
Genes
EFA: EF1818
EFL: EF62_2189(gelE)
EFI: OG1RF_11526(gelE)
EFD: EFD32_1547(gelE)
EFN: DENG_02000
EFQ: DR75_810(gelE)
ENE: ENT_12320
Reference
1  [PMID:4451671]
  Authors
Desmazeaud MJ.
  Title
[General properties and specificity of action of a neutral intracellular endopeptidase from Streptococcus thermophilus]
  Journal
Biochimie 56:1173-81 (1974)
DOI:10.1016/S0300-9084(74)80008-8
Reference
2
  Authors
Desmazeaud, M.J. and Zevaco, C.
  Title
General properties and substrate specificity of an intracellular neutral protease from Streptococcus diacetilactis.
  Journal
Ann Biol Anim Biochem Biophys 16:851-868 (1976)
Reference
3  [PMID:6779709]
  Authors
Smith RA, Green J, Kopper PH.
  Title
The purification and properties of a fibrinolytic neutral metalloendopeptidase from Streptococcus faecalis.
  Journal
Arch Biochem Biophys 202:629-38 (1980)
DOI:10.1016/0003-9861(80)90471-3
Reference
4  [PMID:2536744]
  Authors
Makinen PL, Clewell DB, An F, Makinen KK.
  Title
Purification and substrate specificity of a strongly hydrophobic extracellular metalloendopeptidase ("gelatinase") from Streptococcus faecalis (strain 0G1-10).
  Journal
J Biol Chem 264:3325-34 (1989)
  Sequence
[efa:EF1818]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.30
IUBMB Enzyme Nomenclature: 3.4.24.30
ExPASy - ENZYME nomenclature database: 3.4.24.30
BRENDA, the Enzyme Database: 3.4.24.30
CAS: 156859-08-4

  All links  
Gene (8)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (7)   
Protein sequence (148)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (145)   
DNA sequence (3018)   
   RefSeq(nuc) (2623)   
   GenBank (201)   
   EMBL (194)   
Protein domain (6)   
   InterPro (6)   
All databases (3180)   

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