KEGG ENZYME: 3.4.24.34

ENZYME: 3.4.24.34

Entry

EC 3.4.24.34                Enzyme

Name

neutrophil collagenase;
matrix metalloproteinase 8;
PMNL collagenase;
MMP-8

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I

Comment

Similar to interstitial collagenase in specificity, but the product of a different gene and highly glycosylated. Stored in the specific granules of neutrophil leukocytes. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.7

History

EC 3.4.24.34 created 1992

Orthology

K01402

matrix metalloproteinase-8 (neutrophil collagenase)

Genes

HSA:	4317(MMP8)

PTR:	740516(MMP8)

PPS:	100967517(MMP8)

GGO:	101130698(MMP8)

PON:	100459562(MMP8)

NLE:	100590326(MMP8)

HMH:	116477418(MMP8)

MCC:	703536(MMP8)

MCF:	102141209(MMP8)

MTHB:

126935446

MNI:	105493706(MMP8)

CSAB:

103248338(MMP8)

CATY:

105588776(MMP8)

PANU:

100999640(MMP8)

TGE:	112606698(MMP8)

MLEU:

105542740(MMP8)

RRO:	104674673(MMP8)

RBB:	108514067(MMP8)

TFN:	117080307(MMP8)

PTEH:

111540072(MMP8)

CANG:

105500942(MMP8)

CJC:	100392602(MMP8)

SBQ:	101052201(MMP8)

CIMI:

108315437(MMP8)

CSYR:

103258290(MMP8)

MMUR:

105874593(MMP8)

LCAT:

123641889(MMP8)

PCOQ:

105822218(MMP8)

OGA:	100950955(MMP8)

MMU:	17394(Mmp8)

MCAL:

110301722(Mmp8)

MPAH:

110327350(Mmp8)

RNO:	63849(Mmp8)

MCOC:

116071920(Mmp8)

ANU:	117699929(Mmp8)

MUN:	110541844(Mmp8)

CGE:	100759953(Mmp8)

MAUA:

110342247(Mmp8)

PROB:

127232908(Mmp8)

PLEU:

114708010(Mmp8)

MORG:

121451292(Mmp8)

MFOT:

126513688

AAMP:

119809252(Mmp8)

NGI:	103731673(Mmp8)

HGL:	101716969(Mmp8)

CPOC:

100724670(Mmp8)

CCAN:

109689288(Mmp8)

DORD:

105980682(Mmp8)

DSP:	122110395(Mmp8)

PLOP:

125348070(Mmp8)

NCAR:

124958966

MMMA:

107145905(Mmp8)

OCU:

100339790

OPI:	101527137(MMP8)

TUP:	102491284(MMP8)

GVR:	103609939(MMP8)

CFA:	489429(MMP8)

CLUD:

112671440(MMP8)

VVP:	112925873(MMP8)

VLG:	121500257(MMP8)

NPO:	129497443(MMP8)

AML:	100480934(MMP8)

UMR:	103662456(MMP8)

UAH:	113260136(MMP8)

UAR:	123792503(MMP8)

ELK:

111153789

LLV:

125078736

MPUF:

106003374(MMP8)

MNP:	132029220(MMP8)

MLK:	131834632(MMP8)

NVS:	122913964(MMP8)

ORO:	101369890(MMP8)

EJU:	114211389(MMP8)

ZCA:	113915035(MMP8)

MLX:	118013052(MMP8)

NSU:	110586173(MMP8)

LWW:	102726871(MMP8)

FCA:	101080995(MMP8)

PYU:	121020773(MMP8)

PCOO:

112865898(MMP8)

PBG:	122482891(MMP8)

PVIV:

125176875(MMP8)

LRUF:

124504839

PTG:	102970860(MMP8)

PPAD:

109257533(MMP8)

PUC:

125910792

AJU:

106976490

HHV:	120219699(MMP8)

BTA:	100336575(MMP8)

BOM:	102264685(MMP8)

BBUB:

102400184(MMP8)

BBIS:

104984393(MMP8)

CHX:	102172738(MMP8)

OAS:	101120601(MMP8)

BTAX:

128060599(MMP8)

ODA:	120876081(MMP8)

CCAD:

122450162(MMP8)

MBEZ:

129553540(MMP8)

SSC:	100523811(MMP8)

CFR:	102517300(MMP8)

CBAI:

105067596(MMP8)

CDK:	105087170(MMP8)

VPC:	102529148(MMP8)

BACU:

103009475(MMP8)

BMUS:

118899662(MMP8)

LVE:	103088779(MMP8)

OOR:	101271219(MMP8)

DLE:	111167575(MMP8)

PCAD:

102995095(MMP8)

PSIU:

116757860(MMP8)

NASI:

112394562(MMP8)

ECB:	100069005(MMP8)

EPZ:	103552634(MMP8)

EAI:	106843116(MMP8)

MYB:	102243196(MMP8)

MYD:	102770824(MMP8)

MMYO:

118664464(MMP8)

MLF:	102426192(MMP8)

PKL:	118713422(MMP8)

EFUS:

103292964(MMP8)

MNA:	107532388(MMP8)

DRO:	112317541(MMP8)

SHON:

118975723(MMP8)

AJM:	119054060(MMP8)

PHAS:

123805580(MMP8)

MMF:	118627934(MMP8)

PPAM:

129086105(MMP8)

HAI:	109376359(MMP8)

RFQ:	117031318(MMP8)

PALE:

102885648(MMP8)

PGIG:

120614285(MMP8)

PVP:	105309854(MMP8)

RAY:	107504636(MMP8)

MJV:	108400679(MMP8)

TOD:	119240914(MMP8)

SARA:

101545653(MMP8)

LAV:	100656135(MMP8)

TMU:

101342032

ETF:	101657848(MMP8)

DNM:	101432739(MMP8)

MDO:	100012425(MMP8)

GAS:	123238993(MMP8)

SHR:	100914807(MMP8)

AFZ:

127558056

PCW:	110215021(MMP8)

OAA:

100079007

XMA:

106699854

XCO:

114153708

PRET:

103476142

CVG:

107091375

SDU:

111222299

SLAL:

111663528

OBO:

105274441

» show all

Reference

1 [PMID:3038863]

Authors

Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG.

Title

The collagen substrate specificity of human neutrophil collagenase.

Journal

J Biol Chem 262:10048-52 (1987)

Reference

2 [PMID:2164002]

Authors

Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL

Title

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

Journal

J Biol Chem 265:11421-4 (1990)

Sequence

[hsa:4317]

Reference

3 [PMID:2159879]

Authors

Knauper V, Kramer S, Reinke H, Tschesche H.

Title

Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms.

Journal

Eur J Biochem 189:295-300 (1990)
DOI:10.1111/j.1432-1033.1990.tb15489.x

Sequence

[hsa:4317]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.34

IUBMB Enzyme Nomenclature:

3.4.24.34

ExPASy - ENZYME nomenclature database:

3.4.24.34

BRENDA, the Enzyme Database:

3.4.24.34

CAS:

9001-12-1

DBGET integrated database retrieval system