Entry
Name
gelatinase B;
92-kDa gelatinase;
matrix metalloproteinase 9;
type V collagenase;
92-kDa type IV collagenase;
macrophage gelatinase;
95 kDa type IV collagenase/gelatinase;
collagenase IV (ambiguous);
collagenase type IV (ambiguous);
gelatinase MMP 9;
MMP 9;
type IV collagen metalloproteinase (ambiguous)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of gelatin types I and V and collagen types IV and V
Comment
Similar to gelatinase A, but possesses a further domain . In peptidase family M10 (interstitial collagenase family)
History
EC 3.4.24.35 created 1992
Orthology
K01403 matrix metalloproteinase-9 (gelatinase B)
Genes
TOD : 119237691 119254508(MMP9)
CPIC : 101933485 101936391(MMP9) 101945434 101945994
PVT : 110086226(MMP9) 110089938
SUND : 121928069(MMP9) 121933666
PGUT : 117668957 117669601(MMP9) 117669616
XLA : 100037129(mmp9.2.L) 108702732(mmp9.2.S) 379663(mmp9.S)
XTR : 100494738(mmp9.2) 448591(mmp9.1)
RTEM : 120918563(MMP9) 120945126(ELSPBP1)
SRX : 107712005(mmp9) 107731127
SANH : 107668111 107678941
CCAR : 109094610 109103880
CAUA : 113077664 113093908 113107624
CGIB : 127963502 128018661
MASI : 127414979 127423999
IFU : 128607895(mmp9) 128607898
SMEO : 124399997 124400510
TFD : 113656210(mmp9) 113656211
CMAO : 118813182(mmp9) 118813183 118813185
PPUG : 119199474 119222598(mmp9)
PRET : 103467157 103467158 103467281
PFOR : 103129676 103129678 103132306 103132307 103132308 103132731 103132870 103151091(mmp9)
PLAI : 106942044 106942810 106942812 106944060 106956283
PMEI : 106912111 106912139 106912965 106913043 106913372 106928272 106928273 106928275(mmp9) 106928276
SASA : 100195428(mmp9) 106566399
STRU : 115165351 115168666
OMY : 100136060(mmp9) 110492670
ONE : 115101934(mmp9) 115132546
OKE : 118359525 118360461(mmp9)
SALP : 112073798 112073904
CCLU : 121537704 121546123
LOC : 102692037(mmp9) 107076748
PSPA : 121298131 121319439
ARUT : 117394324 117404302 117428207
LSM : 121126324 121128006 121128529
» show all
Taxonomy
Reference
Authors
Hibbs MS, Hoidal JR, Kang AH.
Title
Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages.
Journal
Reference
Authors
Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI
Title
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
Journal
J Biol Chem 264:17213-21 (1989)
Sequence
Reference
Authors
Mainardi CL, Hasty KA.
Title
Secretion and glycosylation of rabbit macrophage type V collagenase.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.35