| Entry |
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| Name |
trimerelysin I;
Trimeresurus metalloendopeptidase I;
hemorrhagic proteinase HR1A;
hemorrhagic metalloproteinase HR1A;
metalloproteinase HR1A
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
Cleavage of only two bonds His10!Leu and Ala14!Leu in the insulin B chain
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| Comment |
A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family)
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| History |
EC 3.4.24.52 created 1992
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| Orthology |
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| Reference |
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| Authors |
Omori-Satoh T, Sadahiro S. |
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| Title |
Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts. |
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| Journal |
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| Reference |
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| Authors |
Yamakawa Y, Omori-Satoh T. |
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| Title |
The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis). |
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| Journal |
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| Reference |
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| Authors |
Takeya H, Oda K, Miyata T, Omori-Satoh T, Iwanaga S |
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| Title |
The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis. |
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| Journal |
J Biol Chem 265:16068-73 (1990) |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.52 |
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