KEGG ENZYME: 3.4.24.56

ENZYME: 3.4.24.56

Entry

EC 3.4.24.56                Enzyme

Name

insulysin;
insulinase;
insulin-degrading enzyme;
insulin protease;
insulin proteinase;
insulin-degrading neutral proteinase;
insulin-specific protease;
insulin-glucagon protease;
metalloinsulinase;
IDE

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Degradation of insulin, glucagon and other polypeptides. No action on proteins

Comment

A 110 kDa cytosolic enzyme, known from mammals and the fruit fly, Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family).

History

EC 3.4.24.56 created 1972 as EC 3.4.99.10, transferred 1976 EC 3.4.22.11, transferred 1978 to EC 3.4.99.45, transferred 1993 to to EC 3.4.24.56 (EC 3.4.99.46 created 1992, incorporated 2000)

Orthology

K01408

insulysin

Genes

HSA:

3416(IDE)

PTR:	450608(IDE)

PPS:	100987046(IDE)

GGO:	101141069(IDE)

PON:	100434053(IDE)

NLE:	100593040(IDE)

HMH:	116457478(IDE)

MCC:	698640(IDE)

MCF:	102128252(IDE)

MTHB:

126962846

MNI:	105480260(IDE)

CSAB:

103216264(IDE)

CATY:

105587124(IDE)

PANU:

101009890(IDE)

TGE:	112632174(IDE)

MLEU:

105545530(IDE)

RRO:	104676500(IDE)

RBB:	108532590(IDE)

TFN:	117091736(IDE)

PTEH:

111552174(IDE)

CANG:

105515892(IDE)

CJC:	100385143(IDE)

SBQ:	101050161(IDE)

CIMI:

108282305(IDE)

CSYR:

103266025(IDE)

MMUR:

105872121(IDE)

LCAT:

123649647(IDE)

PCOQ:

105822703(IDE)

OGA:	100942657(IDE)

MMU:	15925(Ide)

MCAL:

110285640(Ide)

MPAH:

110336819(Ide)

RNO:	25700(Ide)

MCOC:

116103790(Ide)

ANU:	117707472(Ide)

MUN:	110545280(Ide)

CGE:	100763752(Ide)

MAUA:

101837906(Ide)

PROB:

127233213(Ide)

PLEU:

114702447(Ide)

MORG:

121454023(Ide)

MFOT:

126511549

AAMP:

119802916 119809108(Ide)

NGI:	103747266(Ide)

HGL:	101706921(Ide)

CPOC:

100719651(Ide)

CCAN:

109688019(Ide)

DORD:

105999378(Ide)

DSP:	122115756(Ide)

PLOP:

125346276(Ide)

NCAR:

124984747

MMMA:

107154482(Ide)

OCU:

100341888

OPI:	101524552(IDE)

TUP:	102491829(IDE)

GVR:	103587520(IDE)

CFA:	477768(IDE)

CLUD:

112672060(IDE)

VVP:	112913877(IDE)

VLG:	121484354(IDE)

NPO:	129515511(IDE)

AML:	100482236(IDE)

UMR:	103667958(IDE)

UAH:	113243168(IDE)

UAR:	123800276(IDE)

ELK:

111144834

LLV:

125084532

MPUF:

101675890(IDE)

MNP:	132016624(IDE)

MLK:	131828650(IDE)

NVS:	122900928(IDE)

ORO:	101380916(IDE)

EJU:	114205152(IDE)

ZCA:	113921843(IDE)

MLX:	118023736(IDE)

NSU:	110589591(IDE)

LWW:	102734656(IDE)

FCA:	101093646(IDE)

PYU:	121036995(IDE)

PCOO:

112854247(IDE)

PBG:	122493029(IDE)

PVIV:

125147967(IDE)

LRUF:

124506994

PTG:	102971779(IDE)

PPAD:

109264657(IDE)

PUC:

125933380

AJU:

106965844

HHV:	120230595(IDE)

BTA:	523752(IDE)

BOM:	102265572(IDE)

BIU:	109552990(IDE)

BBUB:

102390944(IDE)

BBIS:

104990205(IDE)

CHX:	102173809(IDE)

OAS:	101104194(IDE)

BTAX:

128067678(IDE)

ODA:	120873693(IDE)

CCAD:

122446143(IDE)

MBEZ:

129555541(IDE)

SSC:	100155309(IDE)

CFR:	102505022(IDE)

CBAI:

105081901(IDE)

CDK:	105084233(IDE)

VPC:	102525212(IDE)

BACU:

103000770(IDE)

BMUS:

118882606(IDE)

LVE:	103074682(IDE)

OOR:	101275790(IDE)

DLE:	111172492(IDE)

PCAD:

102984672(IDE)

PSIU:

116741559(IDE)

NASI:

112396038(IDE)

ECB:	100071303(IDE)

EPZ:	103559075(IDE)

EAI:	106845083(IDE)

MYB:	102263187(IDE)

MYD:	102758781(IDE)

MMYO:

118669958(IDE)

MLF:	102419916(IDE)

PKL:	118719293(IDE)

EFUS:

103300049(IDE)

MNA:	107543320(IDE)

DRO:	112307411(IDE)

SHON:

118987983(IDE) 118993304

AJM:	119057724(IDE)

PDIC:

114496167(IDE)

PHAS:

123828774(IDE)

MMF:	118632197(IDE)

PPAM:

129070019(IDE)

HAI:	109380938(IDE)

RFQ:	117036165(IDE)

PALE:

102895302(IDE)

PGIG:

120609305(IDE)

PVP:	105293081(IDE)

RAY:	107514007(IDE)

MJV:	108398048(IDE)

TOD:	119234348(IDE)

SARA:

101546541(IDE)

LAV:	100655439(IDE)

TMU:

101340940

ETF:	101661484(IDE)

DNM:	101431307(IDE)

MDO:	100024067(IDE)

GAS:	123238218(IDE)

SHR:	100919889(IDE)

AFZ:

127551694

PCW:	110192735(IDE)

OAA:	100074945(IDE)

GGA:	423814(IDE)

PCOC:

116231760(IDE)

MGP:	100542747(IDE)

CJO:	107315974(IDE)

TPAI:

128078065(IDE)

LMUT:

125693385(IDE)

NMEL:

110399870(IDE)

APLA:

101796419(IDE)

ACYG:

106039786(IDE)

CATA:

118245405(IDE)

AFUL:

116491502(IDE)

TGU:	100232369(IDE)

LSR:	110473710(IDE)

SCAN:

103813910(IDE)

PMOA:

120502213(IDE)

OTC:	121341944(IDE)

PRUF:

121350290(IDE)

GFR:	102044722(IDE)

FAB:	101813235(IDE)

OMA:	130254989(IDE)

PHI:	102107945(IDE)

PMAJ:

107206642(IDE)

CCAE:

111931199(IDE)

CCW:	104696227(IDE)

CBRC:

103624518(IDE)

ETL:	114071272(IDE)

ZAB:	102067409(IDE)

ACHL:

103810838(IDE)

SVG:	106852609(IDE)

MMEA:

130582416(IDE)

HRT:	120755558(IDE)

FPG:	101918348(IDE)

FCH:	102053322(IDE)

CLV:	102093029(IDE)

EGZ:	104129064(IDE)

NNI:	104013845(IDE)

PCRI:

104033807(IDE)

EHS:

104502840

ACUN:

113481458(IDE)

TALA:

116962475(IDE)

PADL:

103916353(IDE)

AFOR:

103897849(IDE)

ACHC:

115348011(IDE)

HALD:

104315641(IDE)

HLE:	104830164(IDE)

AGEN:

126042769

GCL:

127017573

CCRI:

104158030(IDE)

CMAC:

104482964(IDE)

MUI:	104546331(IDE)

BREG:

104638998

FGA:	104081716(IDE)

GSTE:

104260620(IDE)

LDI:	104344001(IDE)

MNB:	103773016(IDE)

OHA:	104330485(IDE)

NNT:	104403572(IDE)

SHAB:

115607943(IDE)

DPUB:

104297796(IDE)

PGUU:

104457986

ACAR:

104527734(IDE)

CPEA:

104390913(IDE)

AVIT:

104281493(IDE)

CVF:	104289775(IDE)

RTD:	128911791(IDE)

CUCA:

104067942(IDE)

TEO:	104380369(IDE)

BRHI:

104502156(IDE)

AAM:	106491518(IDE)

NPD:	112957530(IDE)

TGT:	104566390(IDE)

DNE:	112979712(IDE)

SCAM:

104145974(IDE)

ASN:	102372742(IDE)

AMJ:	102565114(IDE)

CPOO:

109323847(IDE)

GGN:	109287505(IDE)

PSS:	102457580(IDE)

CMY:	102939264(IDE)

CCAY:

125640696(IDE)

DCC:	119858369(IDE)

CPIC:

101951441(IDE)

TST:	117880881(IDE)

CABI:

116832421(IDE)

MRV:	120409254(IDE)

ACS:	100562442(ide) 103282118

ASAO:

132771084(IDE)

PVT:	110073578(IDE)

SUND:

121926347(IDE)

PBI:	103064318(IDE)

PMUR:

107283394(IDE)

CTIG:

120304926(IDE)

TSR:

106540499

PGUT:

117673198(IDE)

APRI:

131200603(IDE)

PTEX:

113442795(IDE)

NSS:	113414043(IDE)

VKO:	123018500(IDE)

PMUA:

114597338(IDE)

PRAF:

128414065(IDE)

ZVI:	118096665(IDE)

HCG:	128349793(IDE)

GJA:	107106472(IDE) 107110237

STOW:

125437528(IDE)

EMC:	129332032(IDE)

XLA:	108696126(ide.L) 108697399(ide.S)

XTR:	100490154(ide)

NPR:	108788832(IDE)

RTEM:

120946945(IDE)

BBUF:

121005991(IDE)

BGAR:

122939988(IDE)

MUO:	115470103(IDE)

GSH:	117358688(IDE)

DRE:	561390(ide)

SRX:	107719220(ide) 107747278

SANH:

107665588 107676380

SGH:	107549153 107586078

CCAR:

109067563 109100554

CAUA:

113092350 113112434

CGIB:

127970240 128025945

PTET:

122356690(ide)

LROH:

127174912(ide)

OMC:	131552085(ide)

PPRM:

120479378(ide)

RKG:	130083166(ide)

MAMB:

125276696(ide)

CIDE:

127525125

MASI:

127412192 127414409

TROS:

130558899(ide)

TDW:	130431479(ide)

MANU:

129416676(ide)

IPU:

108263145

IFU:	128605870(ide)

PHYP:

113538031(ide)

SMEO:

124399439(ide)

TFD:	113660997(ide)

TVC:	132847470(ide)

AMEX:

103033253(ide)

CMAO:

118810632(ide)

EEE:	113579898(ide)

CHAR:

105893474(ide)

TRU:	101066029(ide)

TFS:	130534200(ide)

TNG:	GSTEN00003718G001

LCO:	104921911(ide)

NCC:

104941703

TBEN:

117475606(ide)

CGOB:

115020494(ide)

PGEO:

117460109(ide)

GACU:

117551066(ide)

EMAC:

134858871(ide)

ELY:	117248183(ide)

EFO:	125904090(ide)

PLEP:

121954332(ide)

SLUC:

116047860(ide)

ECRA:

117960925(ide)

ESP:	116705140(ide)

PFLV:

114572292(ide)

GAT:	120820385(ide)

PPUG:

119214047(ide)

AFB:	129092137(ide)

CLUM:

117743828(ide) 117744323

PSWI:

130207141(ide)

MSAM:

119917161(ide)

SCHU:

122884810(ide)

CUD:	121510815(ide)

ALAT:

119033352(ide)

MZE:	101464415 101465473

ONL:	100692389 100706901

OAU:	116309660 116318769(ide)

OLA:	101157559 101158223 101163025

OML:	112141524 112145324 112145325(ide)

CSAI:

133463823(ide)

XCO:	114137656(ide)

XHE:	116713150 116713643

PRET:

103477096(ide)

PFOR:

103148263(ide)

PLAI:

106939392

PMEI:

106930457(ide)

GAF:	122842242(ide)

PPRL:

129352647(ide)

CVG:	107088202(ide)

CTUL:

119782902(ide)

GMU:	124858728(ide)

NFU:	107375781(ide)

KMR:	108247174(ide)

ALIM:

106526539(ide)

NWH:	119410718(ide)

AOCE:

111572830(ide)

MCEP:

125018472(ide)

CSEM:

103387481(ide)

POV:	109633847(ide)

SSEN:

122781693(ide)

HHIP:

117775830(ide)

HSP:	118119377(ide)

SMAU:

118284115(ide)

LCF:

108886288

SDU:	111220621(ide)

SLAL:

111669525(ide)

XGL:	120796443(ide)

HCQ:	109523193(ide)

SSCV:

125978857

SBIA:

133509548(ide)

PEE:	133410190(ide)

PTAO:

133485501(ide)

BPEC:

110161080(ide)

MALB:

109959169(ide)

BSPL:

114870821(ide)

SJO:	128372420(ide)

SASA:

106576795 106604847

STRU:

115153037 115193970

OTW:	112252831 112252932

OMY:	110502301 110526671(ide)

OGO:	124038134 124041415

ONE:	115113359 115135279

OKI:	109889801 109899612

OKE:	118369534 118401685

SALP:

111951795 111977826

SNH:	120017537 120046482

CCLU:

121553687 121569094(ide)

ELS:	105005727(ide)

SFM:	108925811(ide)

PKI:	111850359(ide)

AANG:

118217913(ide)

LOC:	102686331(ide)

PSPA:

121321877 121325232

ARUT:

117415575 117418117

PSEX:

120540278(ide)

LCM:	102363186(IDE)

CMK:	103180581(ide)

RTP:	109912130(ide)

CPLA:

122561097(ide)

HOC:	132826234(ide)

LERI:

129703913(ide)

PMRN:

116940466(IDE)

LRJ:	133343319(IDE)

BFO:

118413042

BBEL:

109478554

CIN:

100177319

SCLV:

120340145

SPU:	574555 591315

LPIC:

129273457 129273458

APLC:

110981248

AJC:

117108693

SKO:

102806877

DME:	Dmel_CG5517(Ide)

DER:

6544553

DSE:

6616289

DSI:	Dsimw501_GD12197(Dsim_GD12197)

DYA:	Dyak_GE22411

DAN:

6506778

DSR:

110184656

DPO:

4813975

DPE:

6603355

DMN:

108152750

DWI:

6638788

DGR:

6557764

DMO:	Dmoj_GI13481

DNV:

108650229

DHE:

111592276

DVI:

6624225

CCAT:

101459832

BOD:

106619491

BDR:

105227909

RZE:

108369177

AOQ:

129243038

TDA:

119672893

MDE:	101899568 131803117

SCAC:

106096173

LCQ:

111677349

LSQ:

119600668

GFS:

119632008

ECOE:

129942422

CLON:

129613619

HIS:	119647481 119649272

AGA:

1272688

ACOZ:

120956720

AARA:

120902153

AMER:

121599668

ASTE:

118517646

AFUN:

125769139

AMOU:

128306677

AALI:

118463844

AAG:	110678158 5575268

AALB:

109413566

CQU:	CpipJ_CPIJ006153

CPII:

120424413

CNS:

116337890

BCOO:

119071649

AME:

413539

ACER:

107992697

ALAB:

122715613

ADR:

102674311

AFLR:

100868377

BIM:

100740682

BBIF:

117208070

BVK:

117240265

BVAN:

117164496

BTER:

100644699

BAFF:

126924114

BPYO:

122576116

BPAS:

132911940

FVI:

122529771

CCAL:

108631858

OBB:

114879359

OLG:

117603753

MGEN:

117220685

NMEA:

116428662

CGIG:

122396037

SOC:

105205327

MPHA:

105830806 105839814

AEC:	105152472 105152492

ACEP:

105620850

PBAR:

105425760 105425777 105425778 105425798 105425799 105427238

VEM:	105563049 105565695 105567598

HST:	105185119 105189706

DQU:	106741566 106742500 106750535

CFO:	105249060 105258460

FEX:	115233687 115246321

LHU:	105667811 105671329

PGC:	109858418 109858911 109859391

OBO:

105274769

PCF:

106786397

PFUC:

122521368

VPS:

122637713

VCRB:

124426998

VVE:

124946939

NVI:

100114345

CSOL:

105363243

TPRE:

106657989

LHT:	122501797 122509662

LBD:	127277972 127285452

MDL:	103576120 103579756

CGLO:

123272463

FAS:	105271942 105273032

DAM:

107041090

AGIF:

122858899

CINS:

118072420

VCAN:

122412747

CCIN:

107271454

DSM:	124411425 124411532

NPT:	124220466 124220467 124220470 124220471

NFB:	124182024 124183245 124183247

NLO:	107217952 107219764 107220283 124294696

NVG:	124305886 124305887

AROA:

105689100

TCA:

660586

DPA:

109543947

SOY:

115881971

AGRG:

126736275

ATD:

109605259

CSET:

123317796

AGB:

108917873

LDC:

111509946

NVL:

108562427

APLN:

108741211

PPYR:

116163380

OTU:

111416099

BMOR:

101745525

BMAN:

114246172

MSEX:

115454235

DPL:	KGM_211055A KGM_211055B

MJU:

123878820

NIQ:

126779453

VCD:

124541577

MCIX:

123666755

PMAC:

106716963

PPOT:

106107646

PXU:

106116140

PRAP:

110998472

PBX:

123709449

PNAP:

125053745

ZCE:

119839051

CCRC:

123702141

LSIN:

126973225

HAW:

110375755

HZE:

124644348

TNL:

113505516

SLIU:

111351395

OFU:

114355000

PXY:	105396216 105396278 105398789

PGW:

126378824

CFEL:

113376116 113378482 113379573

CCRN:

123299291

API:

100167928

DNX:

107173966

AGS:	114126529 114128610

RMD:	113548808 113557884

ACOO:

126840285

DVT:

126906053

BTAB:

109037866

DCI:

103512936

CLEC:

106666217

HHAL:

106680575

NLU:

111058304

HVI:

124354158

MQU:	128985893 128986212

PHU:	Phum_PHUM003750

FOC:

113210134

TPAL:

117647137

ZNE:

110833158

CSEC:

111864772 117282033

SGRE:

126278967

BROR:

134530658

IEL:

124155538

FCD:	110845618 110846814 110850482 110854575 110856794 110856939 110857492 110860916 110862143

DPX:	DAPPUDRAFT_305640

DMK:

116926288

DPZ:

124315126

PVM:

113821673

PJA:

122262577

PCHN:

125029568

PMOO:

119581155

HAME:

121854243

PCLA:

123764112

CQD:

128701867

PTRU:

123502918

ESN:	126990496 127005405

HAZT:

108668955

EAF:	111706311 111706459

LSM:	121118111 121129636

TCF:	131878760 131885755

PPOI:

119101135

DSV:

119457502

RSAN:

119379410

RMP:

119175663

VDE:	111242942 111243342 111244578 111245308 111246384 111249273 111255291

VJA:	111258856 111260626 111263062 111265757 111266466 111266586 111269255

DPTE:

113790375

DFR:

124492350

CSCU:

111634626

PTEP:

107436385

ABRU:

129960082

UDV:

129218037

SDM:

118194410

LPOL:

106469262 106472819

PMEO:

129584784

CEL:	CELE_C02G6.2(C02G6.2) CELE_F44E7.4(F44E7.4) CELE_Y70C5C.1(Y70C5C.1)

CBR:	CBG_09322 CBG_17023

CRQ:	GCK72_017803

NAI:	NECAME_12077

BMY:	BM_BM13793(Bm13793)

LOA:	LOAG_08082

TSP:

Tsp_00424

HRO:	HELRODRAFT_109371

LGI:	LOTGIDRAFT_232210

PCAN:

112564175

BGT:

106059917

GAE:	121383266 121384415

HRF:	124117264 124143872

HRJ:	124258429 124259345

CRG:

105329003

CVN:

111101895

CANU:

128180557

OED:

125659579

MYI:	110455364 110459151

PMAX:

117339419 117339446

MCAF:

127733288

MMER:

123546540

RPHI:

132720501 132736075

DPOL:

127841385

OBI:

106875967

OSN:

115219912

LAK:	106168930 106180939

SMM:	Smp_011100 Smp_146010

OVI:	T265_04051

EGL:

EGR_05548

NVE:

5509246

EPA:

110231484

ATEN:

116308795

ADF:

107350280

AMIL:

114961712

PDAM:

113669966

SPIS:

111324398

DGT:

114515965

XEN:

124444752

HMG:	100205092 101236769

HSY:

130644777

TAD:	TRIADDRAFT_28404

AQU:

100632301

ATH:	AT2G41790 AT3G57470

ALY:	9314222 9314223 9316021

CRB:	17885035 17886354 17889182 17889511

CSAT:

104699389 104712420 104712421 104713937 104715299 104752120 104784127 104785199 104792037 109124581

EUS:	EUTSA_v10005770mg EUTSA_v10016187mg

BRP:	103841652 103863042 103866587

BNA:	106396187 106410876 106415623 106445196 106450648 106451568 111214975

BOE:	106300306 106312439 106321110 106336575

RSZ:	108813078 108814401 108829670 108829671 108829672 108863355 130511796

THJ:	104802114 104824443

CPAP:

110811224

CIT:	102625307 102629343

CIC:	CICLE_v10004240mg CICLE_v10004250mg

MINC:

123224732

TCC:	18598933 18598935 18598944

GRA:	105785350 105785352

GHI:	107921220 107921627 107922017 121213639

GAB:	108481936 108481937

HSYR:

120124171 120154160

DZI:	111294450 111311511 111311512 111311513

EGR:	104414623 104445012 104445029 120285897 120285898 120285916

GMX:	100788622 100804856

GSJ:	114400184 114406717

PVU:	PHAVU_001G1332000

VRA:

106757584

VAR:

108328969

VUN:

114179662

VUM:

124819797

CCAJ:

109797247

APRC:

113861524

MTR:

25499023

TPRA:

123888334

CAM:

101508744

PSAT:

127126325

VVO:

131610343

LJA:	Lj0g3v0331639.1(Lj0g3v0331639.1) Lj0g3v0331639.2(Lj0g3v0331639.2)

ADU:

107492618

AIP:

107645485

AHF:	112696027 112755426

LANG:

109340850 109356953

PCIN:

129311874

QSA:	O6P43_006506 O6P43_010141

FVE:

101297565

RCN:	112193461 112193462 112193625

PPER:

18771330

PMUM:

103322039 103322040

PAVI:

110773385

PDUL:

117633672 117633792

MDM:	103400282 103454415

MSYL:

126593826 126600659

PXB:	103946506 103946507 103968020

ZJU:

107431720

MNT:

21388248

CSAV:

115709771

CSV:	101207568 101207811

CMO:

103486819

BHJ:

120091708

MCHA:

111021555

CMAX:

111481567

CMOS:

111441824

CPEP:

111790335

RCU:	8286299 8286300

JCU:	105645230 105645231 105645233

HBR:	110643838 110648272 110660413 110661319 110662163 110673582

MESC:

110620723 110622746 110622795

POP:

7473617

PEU:

105142229

PALZ:

118053175 118053176 118053177

JRE:	108987792 109003515 109004639

CILL:

122275122 122278982

CAVE:

132191769

QSU:	112027923 112034313

QLO:

115953732

TWL:

119991175

VVI:	100241851 100246976

VRI:	117920111 117920763

SLY:	101244763 543773(ide)

SPEN:

107017808 107017877

SOT:	102606094 102606434

SSTN:

125856873 125856874

SDUL:

129870667 129871444

CANN:

107870070 107870071

LBB:	132615068 132615069

NTA:	107764696 107769755 107821603 107825793

NSY:	104231856 104244490

NTO:	104115258 104121323

NAU:	109239863 109239864

INI:	109181420 109181421 109181820

ITR:	116006578 116006692

SIND:

105159756

OEU:

111365873

EGT:

105949356

SSPL:

121746983 121748336 121752292 121790165

SMIL:

131001516

SHIS:

125188423

APAN:

127264630

HAN:

110884632

ECAD:

122606886

LSV:

111879375

CCAV:

112517896

DCR:

108227588

CSIN:

114318147

RVL:	131319023 131319024

AEW:	130788971 130789662 130789868

BVG:

104889352

SOE:

110779098

CQI:	110691497 110707281

ATRI:

130801073

MOF:

131167344

NNU:	104597372 104597374

MING:

122065322

TSS:

122642097

PSOM:

113307965 113310373 113321620

OSA:	4326432 4343659 4343660 9266542

DOSA:

Os01t0778800-01(Os01g0778800) Os01t0779100-00(Os01g0779100) Os07t0570100-01(Os07g0570100) Os07t0570300-01(Os07g0570300) Os07t0570500-01(Os07g0570500)

OBR:	102700359 102709753 102720094

OGL:	127762994 127763008 127778829 127778830 127778831

BDI:	100828166 100843556 100846895

ATS:	109743057 109775769

TDC:	119269204 119277197 119354072 119363262

TAES:

123044489 123052352 123062240 123070990 123079370 123188197

TUA:	125536561 125544991

LPER:

127332992 127344022

LRD:	124665042 124669357

SBI:	110432528 8054706

ZMA:	103633315 103636601 103651144

SITA:

101755850 101776553

SVS:	117844527 117856992

PVIR:

120650747 120661731 120673615 120692205 120708262

PHAI:

112880219 112893810

PDA:

103717655

EGU:

105046510

MUS:

103975260

ZOF:	122010200 122010201 122010203 122014126 122016351

PEQ:

110029154

AOF:

109833714

MSIN:

131221633

NCOL:

116256933

ATR:	18428917 18428919

SMO:	SELMODRAFT_183357 SELMODRAFT_447027

PPP:	112282066 112287795 112291094 112293272

CRE:	CHLRE_09g386113v5

VCN:	VOLCADRAFT_105585 VOLCADRAFT_94765

MNG:

MNEG_3943

CSL:	COCSUDRAFT_30601

CVR:	CHLNCDRAFT_35384

APRO:

F751_6272

CME:	CYME_CMO219C

GSL:	Gasu_10170

CCP:	CHC_T00006291001

SCE:	YLR389C(STE23)

SEUB:

DI49_3889

SPAO:

SPAR_L03980

AGO:	AGOS_AER053C

ERC:

Ecym_3273

KLA:	KLLA0_E05105g

KMX:	KLMA_70067(STE23)

LTH:	KLTH0D14278g

VPO:	Kpol_1055p83

ZRO:	ZYRO0B12320g

CGR:	CAGL0H06457g

NCS:	NCAS_0J01470(NCAS0J01470)

NDI:	NDAI_0J02240(NDAI0J02240)

TPF:	TPHA_0B02260(TPHA0B02260)

TBL:	TBLA_0A08050(TBLA0A08050) TBLA_0I02940(TBLA0I02940)

TGB:	HG536_0E01660

TDL:	TDEL_0E01250(TDEL0E01250)

KAF:	KAFR_0A05970(KAFR0A05970)

KNG:	KNAG_0B06080(KNAG0B06080)

ZMK:	HG535_0B06380

PPA:	PAS_chr1-4_0511

DHA:	DEHA2A05192g

PIC:	PICST_56651

PGU:	PGUG_00170

SPAA:

SPAPADRAFT_143847

LEL:	PVL30_005696(STE23)

CAL:	CAALFM_C602860WA(STE23)

CTP:	CTRG_02123 CTRG_05751 CTRG_05771

COT:	CORT_0H02160

CDU:	CD36_63250

CTEN:

CANTEDRAFT_99150

YLI:	YALI0E17831g YALI0F25091g

CLU:	CLUG_02178

CLUS:

A9F13_02g01221

CAUR:

CJI96_0004056

SLB:	AWJ20_816(STE23)

PKZ:	C5L36_0B12870

BNN:	FOA43_004812

BBRX:

BRETT_001915

OPA:	HPODL_01967

SLUD:

SCDLUD_004250

NCR:

NCU00481

NTE:	NEUTE1DRAFT82494(NEUTE1DRAFT_82494)

SMP:	SMAC_12071

PAN:	PODANSg5055

PBEL:

QC761_706640(STE23)

PPSD:

QC762_706640(STE23)

TTT:	THITE_2118447

MTM:	MYCTH_2304722

MGR:

MGG_13149

TMN:	UCRPA7_6437

SSCK:

SPSK_06929

FGR:	FGSG_06911

FPU:	FPSE_11749

FVN:	FVRRES_11656

FVR:	FVEG_14030

FOX:	FOXG_01908 FOXG_06921 FOXG_12571 FOXG_12622 FOXG_13969 FOXG_16289 FOXG_17054

NHE:	NECHADRAFT_68465

FFC:	NCS54_00567800

FKR:	NCS57_00605700

FMU:	J7337_002675

TRE:	TRIREDRAFT_73809

TRR:	M419DRAFT_139701

MAW:

MAC_03112

MAJ:	MAA_05780 MAA_11828

CMT:

CCM_02661

AMUS:

LMH87_008841

PTKZ:

JDV02_001046(STE23)

VAL:	VDBG_06702

VDA:	VDAG_05762

CLUP:

CLUP02_03384

CHIG:

CH63R_02500

SAPO:

SAPIO_CDS5364

ELA:	UCREL1_6314

PFY:	PFICI_07549 PFICI_10843

SSL:	SS1G_08876

BFU:	BCIN_16g02680

MBE:

MBM_00273

PSCO:

LY89DRAFT_581710 LY89DRAFT_588283 LY89DRAFT_766505

GLZ:	GLAREA_05982

ANI:	ANIA_08044

AFM:	AFUA_5G02010

ACT:	ACLA_003260

NFI:	NFIA_040110

AOR:	AO090003001317

ANG:	An07g06490 An16g01860

AFV:	AFLA_000361

ALUC:

AKAW2_70152S(IDE1)

ACHE:

ACHE_51053A(IDE1)

APUU:

APUU_41509S(IDE1)

PCS:	N7525_008004

PDP:	PDIP_47890

POU:	POX_a00049

TMF:	EYB26_005172

TRG:	TRUGW13939_02639

CIM:	CIMG_06411

CPW:	CPC735_029100

URE:	UREG_03995

PBL:	PAAG_04661

PBN:	PADG_07053 PADG_11423

ABE:

ARB_00823

TVE:

TRV_07483

AJE:	HCAG_00321

BGH:	BDBG_01567

PNO:	SNOG_11020

PTE:

PTT_06680

BZE:	COCCADRAFT_8266

BSC:	COCSADRAFT_83803

BOR:	COCMIDRAFT_9183

AALT:

CC77DRAFT_948948

ARAB:

EKO05_0010217

ZTR:	MYCGRDRAFT_110531

PFJ:	MYCFIDRAFT_165332

FFU:	CLAFUR5_07226

CBET:

CB0940_09904

BCOM:

BAUCODRAFT_75180

NPA:	UCRNP2_1990

TML:	GSTUM_00003807001

SPO:	SPACUNK4.12c(mug138)

SOM:	SOMG_00212(iph1)

CNE:

CNL05710

CNB:

CNBI1120

CNG:	CNAG_07805

CGI:	CGB_D1300C

CDEU:

CNBG_4635

TMS:	TREMEDRAFT_73292

TASA:

A1Q1_07495

CCAC:

CcaHIS019_0305440(STE23)

TVS:	TRAVEDRAFT_66168 TRAVEDRAFT_70638

DSQ:	DICSQDRAFT_132271 DICSQDRAFT_172476

PCO:	PHACADRAFT_249147 PHACADRAFT_255847

SHS:	STEHIDRAFT_118845

HIR:	HETIRDRAFT_31896

PSQ:	PUNSTDRAFT_53482

ADL:	AURDEDRAFT_110880

FME:

FOMMEDRAFT_109506 FOMMEDRAFT_113079 FOMMEDRAFT_149732 FOMMEDRAFT_156520 FOMMEDRAFT_160675 FOMMEDRAFT_160677 FOMMEDRAFT_160684 FOMMEDRAFT_160691 FOMMEDRAFT_160811 FOMMEDRAFT_164257 FOMMEDRAFT_170571 FOMMEDRAFT_170573 FOMMEDRAFT_20973 FOMMEDRAFT_73398 FOMMEDRAFT_74907 FOMMEDRAFT_75209 FOMMEDRAFT_84908 FOMMEDRAFT_94441 FOMMEDRAFT_94516

GTR:	GLOTRDRAFT_119876

RSX:	RhiXN_04469

LBC:	LACBIDRAFT_244036

CCI:	CC1G_01115

ABP:	AGABI1DRAFT68291(AGABI1DRAFT_68291)

ABV:	AGABI2DRAFT199158(AGABI2DRAFT_199158)

MRR:	Moror_14816 Moror_16162 Moror_8369

E1B28_006704 E1B28_009124 E1B28_009207

SCM:	SCHCO_02662021(SCHCODRAFT_02662021)

CPUT:

CONPUDRAFT_69841

SLA:	SERLADRAFT_363280 SERLADRAFT_363284

WSE:	WALSEDRAFT_60480

WIC:	J056_002957

UMA:	UMAG_11953

PFP:	PFL1_05557

SGRA:

EX895_005918

MGL:

MGL_1347

MRT:

MRET_4013

MSYM:

MSY001_0310

PGR:	PGTG_21124

PTRC:

PtA15_11A480

PSTR:

Pst134EA_017404

MLR:	MELLADRAFT_39801

ECU:	ECU06_0750

EIN:	Eint_060670

EHE:	EHEL_060690

ERO:	EROM_060680

DDI:	DDB_G0287851

DPP:	DICPUDRAFT_47068

DFA:

DFA_01586

ACAN:

ACA1_074110

CPV:	cgd1_1680 cgd1_3840 cgd2_4270 cgd2_920 cgd2_930 cgd3_4180 cgd3_4200 cgd3_4210 cgd3_4220 cgd3_4240 cgd3_4250 cgd3_4260 cgd3_4270 cgd6_5520

CHO:	Chro.10431 Chro.20103 Chro.20104 Chro.20459 Chro.30469 Chro.30474 Chro.30475

TGO:	TGME49_257010 TGME49_269885(TLN1)

TET:	TTHERM_000181089 TTHERM_00101300 TTHERM_00277260 TTHERM_00300360 TTHERM_00302040 TTHERM_00590330 TTHERM_00624110 TTHERM_00939020 TTHERM_01108740 TTHERM_01165230

PTM:	GSPATT00000195001 GSPATT00000651001 GSPATT00001153001 GSPATT00002867001 GSPATT00003529001 GSPATT00003618001 GSPATT00006701001 GSPATT00011043001 GSPATT00016702001 GSPATT00021051001 GSPATT00021367001 GSPATT00025091001 GSPATT00025546001 GSPATT00030786001 GSPATT00036196001 GSPATT00036837001 PTMB.304c

SMIN:

v1.2.006079.t1(symbB.v1.2.006079.t1) v1.2.019310.t1(symbB.v1.2.019310.t1) v1.2.033058.t1(symbB.v1.2.033058.t1) v1.2.037748.t1(symbB.v1.2.037748.t1) v1.2.038222.t1(symbB.v1.2.038222.t1)

PTI:	PHATRDRAFT_18335 PHATRDRAFT_47985 PHATRDRAFT_50598

FCY:	FRACYDRAFT_201763 FRACYDRAFT_206890 FRACYDRAFT_209078 FRACYDRAFT_248059 FRACYDRAFT_263926

TPS:	THAPSDRAFT_2118 THAPSDRAFT_262412

NGD:	NGA_0335320(IDE) NGA_0415400(IDE)

AAF:	AURANDRAFT_62143 AURANDRAFT_71803

PIF:	PITG_08991 PITG_17057

PSOJ:

PHYSODRAFT_261837 PHYSODRAFT_519509

SPAR:

SPRG_02382 SPRG_05446 SPRG_05468

EHX:	EMIHUDRAFT_110328 EMIHUDRAFT_449448 EMIHUDRAFT_449760 EMIHUDRAFT_461074 EMIHUDRAFT_471473 EMIHUDRAFT_65626 EMIHUDRAFT_74243 EMIHUDRAFT_74380 EMIHUDRAFT_97098

GTT:	GUITHDRAFT_106094 GUITHDRAFT_45298 GUITHDRAFT_70428

TBR:	Tb927.8.7020

TBG:	TbgDal_VIII7240

TCR:	507389.70 509911.90

LMA:	LMJF_31_3090(SCG5)

LIF:	LINJ_31_3210(SCG5)

LDO:	LDBPK_313210

LMI:	LMXM_30_3090

LBZ:	LBRM_31_3470(SCG5) LBRM_31_3520(SCG5)

LPAN:

LPMP_312970(SCG5)

NGR:	NAEGRDRAFT_35474 NAEGRDRAFT_80868

PSHI:

SAMEA2665130_0904(ptrA_1)

ALIG:

NCTC10568_02300(ptrA_2)

PPR:	PBPRA0963(SO3083)

PGB:	H744_2c1169

PDS:	CAY62_03750

PGH:	FH974_04225

GHO:	AL542_05190

SALY:

E8E00_03275

SKS:	FCN78_09570

SCOT:

HBA18_10055

MAQ:

Maqu_2509

MHC:

MARHY2431

MAD:

HP15_1211

MBS:	MRBBS_1376

MSR:	AU15_14415

MPQ:	ABA45_06415

MARI:

ACP86_17050

MLQ:	ASQ50_03800

MSQ:	BKP64_08400

MARA:

D0851_19455

MARJ:

MARI_06460(ptrA)

MALL:

PBN92_12350

MSHE:

MAALD49_24620

SLO:

Shew_2420

SSE:

Ssed_1634

SPL:

Spea_2592

SHL:

Shal_2664

SWD:

Swoo_3021

SWP:

swp_3134

SVO:

SVI_2900

SPSW:

Sps_01787

SMAV:

CFF01_07205

SBK:	SHEWBE_2214

ILO:

IL0991

ILI:	K734_04980

IPI:	CEW91_08330

IDI:	CWC33_01200

IDT:	C5610_03895

IAB:	K5X84_04220

COZ:	A3Q34_14970

COLW:

A3Q33_04075

COLA:

DBO93_03930

COV:	EKO29_16380

CBER:

B5D82_02070

LSD:	EMK97_04385 EMK97_16295

THT:	E2K93_02625

THAP:

FNC98_10735

PHA:

PSHAa0972

PTN:	PTRA_a1117

PSM:

PSM_A1042

PSEO:

OM33_07330

PIA:	PI2015_1017

PPHE:

PP2015_996

PBW:	D172_005810

PRR:	AT705_06700

PLZ:	S4054249_05800

PALN:

B0W48_19665

PPIS:

B1L02_02910

PEA:	PESP_a1256

PSPO:

PSPO_a0942

PART:

PARC_a2780

PNG:	PNIG_a1176

PTD:	PTET_a1180

PSEN:

PNC201_14055(ptrA1)

PDJ:	D0907_05125

PAGA:

PAGA_a2651

PCAR:

PC2016_0983

PMAA:

CPA52_11170

PXI:	J5O05_05815

PVB:	J5X90_18335

PDV:	FFU37_10285

PFLI:

CTT31_14325

PMAZ:

R5H13_14910

PSYM:

J1N51_13485

AMC:	MADE_000001020955

AMAC:

MASE_05820

AMB:	AMBAS45_06035

AMG:	AMEC673_05890

AMK:	AMBLS11_05880

ALT:	ambt_12335

ASQ:	AVL57_10035

AAW:	AVL56_09180

ALE:	AV939_09050

ALZ:	AV940_08830

APEL:

CA267_003210

SALM:

D0Y50_05675

GAG:	Glaag_2665

GPS:

C427_1902

PMES:

FX988_00965

PAT:

Patl_1666

LAL:	AT746_06315

SALH:

HMF8227_01901

HMI:	soil367_05960

MVS:

MVIS_1042

MYA:	MORIYA_1941

MMAA:

FR932_12630

MOQ:	HWV03_16990

CJA:

CJA_1334

CEB:	B0D95_01785

CELL:

CBR65_07700

CEK:	D0B88_09925

CEG:	D0C16_09115

TTU:	TERTU_1027

SAGA:

M5M_05838

SPOI:

IMCC21906_02681

ZAL:	AZF00_11475

OSG:	BST96_15065

HJA:	BST95_08460

HALC:

EY643_14320

KIM:	G3T16_13685

AFUS:

EYZ66_04525

MEIN:

methR_P0490

TBN:

TBH_C0846

HCH:	HCH_02204 HCH_05001

HAHE:

ENC22_07900

HAHH:

O5O45_15970

CSA:

Csal_3023

HEL:

HELO_3870

HCS:	FF32_08470

HAK:	KO116_03848

HAM:

HALO4126

HCO:	LOKO_03289(ptrA)

HSI:	BOX17_09635

HALO:

BWR19_01915

HHH:	CLM76_03365

HBE:

BEI_3284

HAG:	BB497_01400

HAF:	C8233_12560

HMD:	CTT34_02525

HAXI:

HAALTHF_02350n

HSV:	HNO53_02095

HPRO:

LMS44_02100

HQD:	K1Y77_02060

HBP:	HPTD01_703

HALF:

QEN58_02130

HASO:

B2G49_14210

HALK:

CUU95_03715

HVN:	EI420_02215

HPIZ:

GYM47_02410

HNP:	SR894_01750

HTT:	HZS52_01715

HCAM:

I4484_02265

HSX:	HNO51_02180

ZPL:	ZBT109_0442

HAA:	A5892_18955

CMAI:

BFX80_01250

CAMH:

LCW13_15960

COBE:

CLAM6_32310

KUS:	B9G99_03100

KMA:	B9H00_12050

PAUR:

FGL86_01425

MMW:	Mmwyl1_2863

MPC:	Mar181_1207

MPRI:

MP3633_1344

MARD:

IBG28_07535

MFOI:

JSY38_16220

TOL:

TOL_1037

TOR:	R615_12240

OAI:	OLEAN_C23490

MARS:

A8C75_05415

MGEO:

CFI10_06685

BSAN:

CHH28_17255

NCU:	F0U83_04670

NJP:	NEJAP_0991

NIK:	F5I99_13530

BMAR:

HF888_11370

AJP:	AMJAP_0942

RFO:	REIFOR_02437

OME:	OLMES_3488

LLP:	GH975_03325

AHA:

AHA_1997

AHY:	AHML_12920

AHD:	AI20_07215

AHR:	V428_13350

AHP:	V429_13370

AHJ:	V469_09735

AHH:	RY45_12685

AHI:	VU14_09610

AAJ:	BOQ57_12505

ASA:

ASA_1875

AEO:	O23A_p1165

AVR:

B565_2232

AVO:	AMS64_10920

AMED:

B224_2593

ASR:	WL1483_1605

ADH:	CK627_13850

AEM:	CK911_08195

AEA:	C2U39_09745

AES:	C2U30_04000

AEL:	NCTC12917_01886(ptrA_2)

ASIM:

FE240_08940

AALL:

I6G90_03890

AJD:	I6H43_20265

ARIV:

KYK33_10450

ASAA:

KXJ75_10715

AEJ:	E5E97_17450

ABES:

IU367_12285

TAU:

Tola_2184

CTR:	CT_806(ptr)

CTD:	CTDEC_0806(ptr)

CTF:	CTDLC_0806(ptr)

CTRD:

SOTOND1_00862

CTRO:

SOTOND5_00860

CTRT:

SOTOND6_00860

CTA:	CTA_0878(ptr)

CTY:	CTR_8111(ptr)

CRA:

CTO_0878

CTRQ:

A363_00869

CTRX:

A5291_00868

CTRZ:

A7249_00867

CTRP:

L11322_00856

CTLJ:

L1115_00856

CTLX:

L1224_00857

CTLL:

L1440_00859

CTB:	CTL0175(ptr)

CTRR:

L225667R_00857

CTLF:

CTLFINAL_00940

CTLI:

CTLINITIAL_00940

CTL:	CTLon_0176(ptr)

CTRU:

L2BUCH2_00856

CTRL:

L2BLST_00856

CTRV:

L2BCV204_00856

CTRM:

L2BAMS1_00856

CTLA:

L2BAMS2_00856

CTLM:

L2BAMS3_00856

CTLS:

L2BAMS4_00856

CTLZ:

L2BAMS5_00857

CTLC:

L2BCAN1_00857

CTLN:

L2BCAN2_00855

CTLB:

L2B795_00856

CTLQ:

L2B8200_00856

CTO:

CTL2C_538

CTRN:

L3404_00855

CTJ:	JALI_8121(ptr)

CTZ:	CTB_8121(ptr)

CTG:	E11023_04280

CTK:	E150_04315

CTRB:

BOUR_00864

CTRE:

SOTONE4_00859

CTRS:

SOTONE8_00864

CTEC:

EC599_8481(ptr)

CTFW:

SWFP_8861(ptr)

CTRF:

SOTONF3_00860

CTCH:

O173_04510

CTN:	G11074_04270

CTQ:	G11222_04305

CTV:	CTG9301_04285

CTW:	G9768_04275

CTRG:

SOTONG1_00861

CTRH:

SOTONIA1_00863

CTRJ:

SOTONIA3_00863

CTRK:

SOTONK1_00860

CTJT:

CTJTET1_04470

CTCF:

CTRC69_04305

CTFS:

CTRC342_04500

CTHF:

CTRC852_04515

CTCJ:

CTRC943_04275

CTHJ:

CTRC953_04260

CTMJ:

CTRC966_04285

CTTJ:

CTRC971_04285

CTJS:

CTRC122_04415

CTRC:

CTRC55_04285

CTRW:

CTRC3_04320

CTRY:

CTRC46_04290

CTCT:

CTW3_04525

CMU:

TC_0190

CMUR:

Y015_01005

CMN:	BB17_01025

CMM:	NC80_00960

CMG:	NC81_00975

CMX:

DNC_00975

CMZ:

TAC_01005

CPN:	CPn_0957(ide)

CPA:

CP_0903

CPJ:

ide(ide)

CPT:

CpB0994

CLP:	CPK_ORF00372

CPM:

G5S_0078

CPEC:

CPE3_0772

CPEO:

CPE1_0771(ide)

CPER:

CPE2_0772

CHP:	CPSIT_0862

CHB:

G5O_0851

CHS:	CPS0A_0881

CHI:	CPS0B_0868

CHT:	CPS0D_0878

CHC:	CPS0C_0880

CHR:

Cpsi_7971

CPSC:

B711_0929

CPSN:

B712_0871

CPSB:

B595_0929 B595_0930

CPSG:

B598_0867

CPSM:

B602_0872

CPSI:

B599_0867

CPSV:

B600_0926

CPSW:

B603_0871

CPST:

B601_0870

CPSD:

BN356_8001

CAV:	M832_05800

CCA:	CCA_00812(ide)

CAB:

CAB782

CABO:

AB7_8631

CFE:	CF0202(ide1) CF0203(ide2)

CGZ:	M787_000880

CHLA:

C834K_0834(ptrA)

CSUI:

Chls_210(ptr)

CBUE:

HBN95_01505

CSEE:

C10C_0930(ptrA)

CCRD:

H9Q19_01365

CPAA:

FI836_01650

PNL:

PNK_0535

PUV:	PUV_02500(IDE)

NEY:	NCS13_1_0125

WCH:	wcw_0398(ide)

SNG:	SNE_A18560

OBG:	Verru16b_00710(ptrA_1)

CEC:

CE557_732

NLI:	G3M70_17290

» show all

Reference

1 [PMID:3061785]

Authors

Duckworth WC.

Title

Insulin degradation: mechanisms, products, and significance.

Journal

Endocr Rev 9:319-45 (1988)
DOI:10.1210/edrv-9-3-319

Reference

2 [PMID:2293021]

Authors

Affholter JA, Hsieh CL, Francke U, Roth RA

Title

Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.

Journal

Mol Endocrinol 4:1125-35 (1990)
DOI:10.1210/mend-4-8-1125

Sequence

[hsa:3416]

Reference

3 [PMID:1689296]

Authors

Duckworth WC, Hamel FG, Bennett R, Ryan MP, Roth RA.

Title

Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin.

Journal

J Biol Chem 265:2984-7 (1990)

Reference

4 [PMID:2126597]

Authors

Kuo WL, Gehm BD, Rosner MR

Title

Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.

Journal

Mol Endocrinol 4:1580-91 (1990)
DOI:10.1210/mend-4-10-1580

Sequence

[dme:Dmel_CG5517]