KEGG   ENZYME: 3.4.24.57
Entry
EC 3.4.24.57                Enzyme                                 
Name
O-sialoglycoprotein endopeptidase;
glycoprotease;
glycophorin A proteinase;
glycoproteinase;
sialoglycoprotease;
sialoglycoproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of O-sialoglycoproteins; cleaves -Arg31!Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated
Comment
An enzyme secreted by the bacterium Pasteurella haemolytica. Inhibited by EDTA (100 mM) and 1,10-phenanthroline. Type example of peptidase family M22
History
EC 3.4.24.57 created 1993
Reference
1  [PMID:1885539]
  Authors
Abdullah KM, Lo RY, Mellors A
  Title
Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene.
  Journal
J Bacteriol 173:5597-603 (1991)
DOI:10.1128/JB.173.18.5597-5603.1991
  Sequence
[mht:D648_7650]
Reference
2  [PMID:1729196]
  Authors
Abdullah KM, Udoh EA, Shewen PE, Mellors A.
  Title
A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins.
  Journal
Infect Immun 60:56-62 (1992)
DOI:10.1128/IAI.60.1.56-62.1992
Reference
3  [PMID:1371528]
  Authors
Sutherland DR, Abdullah KM, Cyopick P, Mellors A.
  Title
Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica.
  Journal
J Immunol 148:1458-64 (1992)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.57
IUBMB Enzyme Nomenclature: 3.4.24.57
ExPASy - ENZYME nomenclature database: 3.4.24.57
BRENDA, the Enzyme Database: 3.4.24.57
CAS: 129430-53-1

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