Entry |
|
Name |
leucolysin;
Leucostoma neutral proteinase;
Leucostoma peptidase A
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
|
Reaction(IUBMB) |
Cleavage of Phe1!Val, His5!Leu, Ala14!Leu, Gly20!Glu, Gly23!Phe and Phe24!Phe bonds in insulin B chain as well as N-blocked dipeptides
|
Comment |
From the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma).
|
History |
EC 3.4.24.6 created 1978
|
Reference |
|
Authors |
Wagner FW, Spiekerman AM, Prescott JM. |
Title |
Leucostoma peptidase A. Isolation and physical properties. |
Journal |
J Biol Chem 243:4486-93 (1968) |
Reference |
|
Authors |
Spiekerman AM, Fredericks KK, Wagner FW, Prescott JM. |
Title |
Leucostoma peptidase A: a metalloprotease from snake venom. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 3.4.24.6 |
ExPASy - ENZYME nomenclature database: | 3.4.24.6 |
|