Entry
Name
nardilysin;
N-arginine dibasic convertase;
NRD-convertase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of polypeptides, preferably at -Xaa!Arg-Lys-, and less commonly at -Arg!Arg-Xaa-, in which Xaa is not Arg or Lys
Comment
Enzyme of 133 kDa from rat brain and testis. A homologue of pitrilysin containing the His-Phe-Leu-Glu-His zinc-binding sequence, and a highly acidic stretch of 71 residues. Unusually for a metalloendopeptidase, inhibited by bestatin, amastatin and N-ethylmaleimide. In peptidase family M16 (pitrilysin family)
History
EC 3.4.24.61 created 1995
Orthology
Genes
SBQ : 101038268 101040617(NRD1)
CCAN : 109684273 109693362
APLA : 101803139(NRDC) 101804476
ACYG : 106032938 106033019(NRDC)
AFUL : 116491874 116491876(NRDC)
AAM : 106491058(NRDC) 106491065
AROW : 112975953 112976070(NRDC)
NPD : 112943009(NRDC) 112959889
TGT : 104568251 104577533(NRD1)
DNE : 112986008 112986349(NRDC)
SCAM : 104149616(NRD1) 104149623
ASN : 102378462 102381928(NRDC)
AMJ : 102569440 102573951(NRDC)
CPOO : 109307467(NRDC) 109307489
GGN : 109286664(NRDC) 109305303
PSS : 102453754(NRDC) 102458989
CMY : 102932297 102942086(NRDC)
CCAY : 125641469(NRDC) 125641841
DCC : 119859900(NRDC) 119860086
CPIC : 101936503(NRDC) 101941153
TST : 117881398(NRDC) 117881752
CABI : 116817919(NRDC) 116825217
MRV : 120370085 120370211(NRDC)
ACS : 100557559(nrdc) 100563662
ASAO : 132772847 132773914(NRDC)
PVT : 110073801 110076154(NRDC)
SUND : 121928181(NRDC) 121929831
PBI : 103049165(NRDC) 103052515
PMUR : 107283057(NRDC) 107293690
CTIG : 120297303(NRDC) 120301496
PGUT : 117664220(NRDC) 117668346
APRI : 131193956(NRDC) 131194252
PTEX : 113438206 113440595(NRDC)
NSS : 113411012(NRDC) 113426372
VKO : 123019048 123023390(NRDC)
PMUA : 114599009(NRDC) 114601355
PRAF : 128415775(NRDC) 128417149
ZVI : 118088717(NRDC) 118090098
HCG : 128323826 128324865(NRDC)
GJA : 107111063(NRDC) 107119142
STOW : 125433979(NRDC) 125439504
EMC : 129329714(NRDC) 129333518
XLA : 108714316(nrdc.L) 108715597(nrdc.S)
DRE : 557565(nrd1b) 565850(nrd1a)
SRX : 107706405 107728531 107738192
SANH : 107659423 107669832 107684410
SGH : 107558778 107591325(nrdc) 107592727
CCAR : 109056763 109078041(nrdc)
CAUA : 113039633 113040108 113045469 113119216
CGIB : 127951286 127988319 128031428
PTET : 122324207(nrd1a) 122327235(nrd1b)
LROH : 127154185(nrd1b) 127182982(nrd1a)
OMC : 131523907(nrd1a) 131530673(nrd1b)
PPRM : 120480440(nrd1a) 120486552(nrd1b)
RKG : 130071521(nrd1a) 130089264(nrd1b)
MAMB : 125251352(nrd1a) 125251739(nrd1b)
CIDE : 127498527 127521306
MASI : 127437992 127441560 127442218
TROS : 130548697(nrd1b) 130554150(nrd1a)
TDW : 130417978(nrd1a) 130430314(nrd1b)
IPU : 108268052(nrd1a) 108271269(nrd1b)
IFU : 128609847(nrd1a) 128614000(nrd1b)
PHYP : 113532048 113540477
SMEO : 124387311(nrd1a) 124391124(nrd1b)
TFD : 113647137(nrd1a) 113657794(nrd1b)
TVC : 132848165(nrd1a) 132852552(nrd1b)
AMEX : 103026065 103040156(nrdc)
CMAO : 118819341(nrd1b) 118825712(nrd1a)
CHAR : 105904423(nrd1b) 105906141(nrd1a)
TFS : 130528458 130540391(nrd1a)
TNG : GSTEN00010043G001 GSTEN00031930G001
LCO : 104926594 104938183(nrdc)
TBEN : 117475183 117495668
CGOB : 115007362 115027503
PGEO : 117445313 117467650
EMAC : 134869779(nrd1b) 134881863(nrd1a)
PLEP : 121941064 121953842(nrd1a)
SLUC : 116057499 116059138
ECRA : 117935849(nrd1a) 117950782
PFLV : 114546866 114561154
PPUG : 119216831 119227364
CLUM : 117729222 117751519
PSWI : 130193919 130201442
MSAM : 119900204 119910291
SCHU : 122862090 122877434(nrd1b)
CUD : 121512861(nrd1b) 121526494
ALAT : 119004497 119028816(nrd1b)
OAU : 116323240(nrd1b) 116326064
OLA : 101158595 101160369(nrdc)
OML : 112137026 112142844(nrd1a)
CSAI : 133458325 133462685(nrd1a)
PFOR : 103156364 103156896
PLAI : 106939079 106959795
PMEI : 106910101 106929735(nrdc)
GAF : 122838498(nrd1b) 122846358(nrd1a)
PPRL : 129365391 129379997
CTUL : 119775610(nrd1a) 119791238(nrd1b)
GMU : 124855445(nrd1a) 124873244(nrd1b)
ALIM : 106518483(nrd1) 106537281
NWH : 119427375 119430362(nrd1b)
AOCE : 111563171 111567705
MCEP : 125009879 125023966(nrd1a)
CSEM : 103380052 103399222(nrdc)
POV : 109636417(nrdc) 109646267
SSEN : 122780930 122783126
HHIP : 117756171 117760468
HSP : 118116556 118120780(nrd1b)
SMAU : 118285789 118317837(nrd1b)
LCF : 108874942(nrd1a) 108883383
SDU : 111225500 111227509(nrdc)
SLAL : 111670160 111671724(nrdc)
XGL : 120790402(nrd1b) 120795466
SSCV : 125969057 125980959
SBIA : 133503284 133513478
PTAO : 133481260 133487622
BPEC : 110153439 110165601(nrdc)
MALB : 109965264(nrdc) 109968018
BSPL : 114848712 114853343(nrd1b)
SJO : 128362048(nrd1b) 128375265
SASA : 106574483 106574586 106575437(NRDC) 106613566(NRDC)
OTW : 112250679 112255133 112266380
OMY : 110497079 110524082 110528861
OGO : 123997383(nrd1b) 124007888 124011355
OKI : 109879731 109890379 109902322
CCLU : 121533716 121587411
ELS : 105006736 105011400(nrdc)
AANG : 118225279(nrd1b) 118228850
PSPA : 121326683(nrd1a) 121330705
ARUT : 117409623 117417124
DSI : Dsimw501_GD15963(Dsim_GD15963) Dsimw501_GD17647(Dsim_GD17647)
DYA : Dyak_GE17590 Dyak_GE19720 Dyak_GE23250
DPO : 4815616 6902129 6902220 6902687 6902692 6902933
DPE : 6589623 6597280 6598118 6602869 6602911
DMN : 108156889 108160627 108161132 108165171 117185815 117186941 117186944 117186946 117186950 117186966 117191134
DMO : Dmoj_GI13200 Dmoj_GI16413
AALB : 109397745 109428780 115253889
BCOO : 119071058 119084936 119085010
AEC : 105143891 105143897 105143902 105143911 105144350 105148419 105148479 105148691 105149631 105149956 105153016 105153017
ACEP : 105619096 105619183 105621301 105622483 105626518 105627623 105627624 105627630 105627631 105627632
TPRE : 106654272 106655552
AGIF : 122852005 122860097
VCAN : 122412178 122413873
APLN : 108743237 108744008
PPYR : 116175428 116175594
NLU : 111045936 111063205 120351101
VDE : 111244755 111254068 111254156 111255503
VJA : 111265935 111265936 111267563 111268613
RPHI : 132720095 132725230 132733717
SMM : Smp_061510.1 Smp_155220 Smp_156960.1
OVI : T265_02427 T265_12838
AMIL : 114963248 114971391
CSAT : 104730881 104739254 104759101 104773569 104778592
BRP : 103836464 103843999 103854597
BNA : 106362217 106368996 106401128 106402919 106403009 125591413
BOE : 106295394 106310341 106312264
RSZ : 108805346 108813477 108823061 108833983 130509545
HSYR : 120114591 120200291
PVU : PHAVU_006G0775000 PHAVU_006G0775001
LJA : Lj0g3v0009849.1(Lj0g3v0009849.1) Lj4g3v1983560.1(Lj4g3v1983560.1) Lj6g3v0315180.1(Lj6g3v0315180.1) Lj6g3v0315180.2(Lj6g3v0315180.2)
FVE : 101297043 101304082 101304372 101308581
RCN : 112164565 112164566 112164859 112168412 112176718
MSYL : 126590667 126615721
SSPL : 121743847 121811589
ECAD : 122607136 122607278
PSOM : 113310161 113322082
DOSA : Os03t0336300-01(Os03g0336300)
TAES : 123085800 123092204
PVIR : 120652443 120687973
SMO : SELMODRAFT_154839 SELMODRAFT_157708
MPP : MICPUCDRAFT_16352(JGI:MicpuC2_16352)
SMIN : v1.2.017618.t1(symbB.v1.2.017618.t1)
PIF : PITG_01569 PITG_16759
PSOJ : PHYSODRAFT_491157 PHYSODRAFT_496885
SPAR : SPRG_02713 SPRG_02716
» show all
Taxonomy
Reference
Authors
Gomez S, Gluschankof P, Morel A, Cohen P.
Title
The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes.
Journal
J Biol Chem 260:10541-5 (1985)
Reference
Authors
Gluschankof P, Gomez S, Morel A, Cohen P.
Title
Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex.
Journal
J Biol Chem 262:9615-20 (1987)
Reference
Authors
Chesneau V, Pierotti AR, Barre N, Creminon C, Tougard C, Cohen P.
Title
Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues.
Journal
J Biol Chem 269:2056-61 (1994)
Reference
Authors
Pierotti AR, Prat A, Chesneau V, Gaudoux F, Leseney AM, Foulon T, Cohen P.
Title
N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.61