KEGG ENZYME: 3.4.24.63

ENZYME: 3.4.24.63

Entry

EC 3.4.24.63                Enzyme

Name

meprin B;
meprin-b

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain

Comment

A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)

History

EC 3.4.24.63 created 1995

Orthology

K08606

meprin B

Genes

HSA:	4225(MEP1B)

PTR:	468515(MEP1B)

PPS:	100991143(MEP1B)

GGO:	101131682(MEP1B)

PON:	100461703(MEP1B)

NLE:	100587715(MEP1B)

HMH:	116468628(MEP1B)

MCC:	707036(MEP1B)

MCF:	102120570(MEP1B)

MTHB:

126941563

MNI:	105498299(MEP1B)

CSAB:

103222566(MEP1B)

CATY:

105592602(MEP1B)

PANU:

101001403(MEP1B)

TGE:	112611509(MEP1B)

MLEU:

105535344(MEP1B)

RRO:	104664448(MEP1B)

RBB:	108530921(MEP1B)

TFN:	117064003(MEP1B)

PTEH:

111539602(MEP1B)

CANG:

105512997(MEP1B)

CJC:	100406280(MEP1B)

SBQ:	101032707(MEP1B)

CIMI:

108288236(MEP1B)

CSYR:

103252712(MEP1B)

MMUR:

105881102(MEP1B)

LCAT:

123621712(MEP1B)

PCOQ:

105820145(MEP1B)

OGA:	100954479(MEP1B)

MMU:	17288(Mep1b)

MCAL:

110284973(Mep1b)

MPAH:

110333333(Mep1b)

RNO:	25727(Mep1b)

MCOC:

116087559(Mep1b)

ANU:	117719968(Mep1b)

MUN:	110541057(Mep1b)

CGE:	100774490(Mep1b)

MAUA:

101835986(Mep1b)

PROB:

127234975(Mep1b)

PLEU:

114704981(Mep1b)

MORG:

121441844 121441893 121453336 121453586

MFOT:

126497086 126497087

AAMP:

119815303 119815304

NGI:	103730584(Mep1b)

HGL:	101721966(Mep1b)

CPOC:

100733995(Mep1b)

CCAN:

109700569(Mep1b)

DORD:

105984574(Mep1b)

DSP:	122104256(Mep1b)

PLOP:

125363927(Mep1b)

NCAR:

124965368

MMMA:

107139332(Mep1b)

OCU:

100349918

OPI:	101535433(MEP1B)

TUP:	102501249(MEP1B)

GVR:	103600962(MEP1B)

CFA:	490497(MEP1B)

CLUD:

112648180(MEP1B)

VVP:	112918774(MEP1B)

VLG:	121500881(MEP1B)

NPO:	129509056(MEP1B)

AML:	100474827(MEP1B)

UMR:	103665002(MEP1B)

UAH:	113253198(MEP1B)

UAR:	123782011(MEP1B)

ELK:

111142409

LLV:

125082546

MPUF:

101687936(MEP1B)

MNP:	132022997(MEP1B)

MLK:	131811251(MEP1B)

NVS:	122902946(MEP1B)

ORO:	101362685(MEP1B)

EJU:	114204991(MEP1B)

ZCA:	113912268(MEP1B)

MLX:	118004459(MEP1B)

NSU:	110576950(MEP1B)

LWW:	102732911(MEP1B)

FCA:	101089149(MEP1B)

PYU:	121033031(MEP1B)

PCOO:

112868201(MEP1B)

PBG:	122469999(MEP1B)

PVIV:

125148657(MEP1B)

LRUF:

124517538

PTG:	102972887(MEP1B)

PPAD:

109276429(MEP1B)

PUC:

125914320

AJU:

106984962

HHV:	120246841(MEP1B)

BTA:	540701(MEP1B)

BOM:	102277511(MEP1B)

BIU:	109577975(MEP1B)

BBUB:

102394983(MEP1B)

BBIS:

104980326(MEP1B)

CHX:	102181352(MEP1B)

OAS:	101114072(MEP1B)

BTAX:

128067360(MEP1B)

ODA:	120881181(MEP1B)

CCAD:

122425832(MEP1B)

MBEZ:

129549577(MEP1B)

SSC:	100516141(MEP1B)

CFR:	102509020(MEP1B)

CBAI:

105062611(MEP1B)

CDK:	105087045(MEP1B)

VPC:	102545555(MEP1B)

BACU:

102999400(MEP1B)

BMUS:

118880034(MEP1B)

LVE:	103090304(MEP1B)

OOR:	101287646(MEP1B)

DLE:	111181507(MEP1B)

PCAD:

102977401(MEP1B)

PSIU:

116739028(MEP1B)

NASI:

112408354(MEP1B)

ECB:	100052389(MEP1B)

EPZ:	103558347(MEP1B)

EAI:	106833999(MEP1B)

MYB:	102262211(MEP1B)

MYD:	102761324(MEP1B)

MMYO:

118663201(MEP1B)

MLF:	102438631(MEP1B)

PKL:	118707419(MEP1B)

EFUS:

103292181(MEP1B)

MNA:	107524193(MEP1B)

DRO:	112322891(MEP1B)

SHON:

118980342(MEP1B)

AJM:	119055550(MEP1B)

PDIC:

114505982(MEP1B)

PHAS:

123826198(MEP1B)

MMF:	118619263(MEP1B)

PPAM:

129078822(MEP1B)

HAI:	109387887(MEP1B)

RFQ:	117038642(MEP1B)

PALE:

102878505(MEP1B)

PGIG:

120587130(MEP1B)

PVP:	105293718(MEP1B)

RAY:	107521761(MEP1B)

MJV:	108390781(MEP1B)

TOD:	119242794(MEP1B)

SARA:

101550583(MEP1B)

LAV:	100656666(MEP1B)

TMU:

101351008

ETF:	101662554(MEP1B)

DNM:	101420233(MEP1B)

MDO:	100031050 100031055(MEP1B)

GAS:	123253669 123253691(MEP1B)

SHR:	100920095 100920356 100920611

AFZ:	127543911 127546811

PCW:	110212554(MEP1B)

OAA:	100084811(MEP1B)

GGA:	421097(MEP1B)

PCOC:

116242218

MGP:

100545010

CJO:

107310133

TPAI:

128091408(MEP1B)

LMUT:

125690819(MEP1B)

NMEL:

110394814

APLA:

101794200(MEP1B)

ACYG:

106038392(MEP1B)

CATA:

118251278(MEP1B)

AFUL:

116485636(MEP1B)

TGU:	100227825(MEP1B)

SCAN:

103816093(MEP1B)

PMOA:

120499951(MEP1B)

OTC:	121333145(MEP1B)

PRUF:

121358992(MEP1B)

GFR:	102041784(MEP1B)

FAB:	101820401(MEP1B)

OMA:	130249675(MEP1B)

PHI:	102106845(MEP1B)

PMAJ:

107200153(MEP1B)

CCAE:

111924898(MEP1B)

CCW:	104690416(MEP1B)

CBRC:

103625520(MEP1B)

ETL:	114057191(MEP1B)

ZAB:	102072756(MEP1B)

ACHL:

103800971(MEP1B)

SVG:	106851969(MEP1B)

MMEA:

130572960(MEP1B)

HRT:	120756668(MEP1B)

FPG:	101920674(MEP1B)

FCH:	102052375(MEP1B)

CLV:	102096310(MEP1B)

EGZ:	104126872(MEP1B)

NNI:	104019801(MEP1B)

PCRI:

104030433(MEP1B)

PLET:

104626166(MEP1B)

EHS:	104511128(MEP1B)

PCAO:

104047935(MEP1B)

ACUN:

113476445(MEP1B)

TALA:

104358761(MEP1B)

PADL:

103923149(MEP1B)

AFOR:

103904245(MEP1B)

ACHC:

115340816(MEP1B)

HALD:

104323620(MEP1B)

HLE:	104836069(MEP1B)

AGEN:

126048076

GCL:

127013408

CCRI:

104168754(MEP1B)

CSTI:

104552830(MEP1B)

CMAC:

104474731(MEP1B)

MUI:	104547578(MEP1B)

BREG:

104634479(MEP1B)

FGA:	104082673(MEP1B)

GSTE:

104258902(MEP1B)

LDI:	104343138(MEP1B)

MNB:	103773824(MEP1B)

OHA:	104329165(MEP1B)

NNT:	104400505(MEP1B)

SHAB:

115616978(MEP1B)

DPUB:

104309119(MEP1B)

PGUU:

104459469(MEP1B)

ACAR:

104527222(MEP1B)

CPEA:

104396982(MEP1B)

AVIT:

104271511(MEP1B)

CVF:	104287295(MEP1B)

RTD:	128905537(MEP1B)

CUCA:

104059979(MEP1B)

TEO:	104374421(MEP1B)

BRHI:

104500624(MEP1B)

AAM:	106494484(MEP1B)

AROW:

112969480(MEP1B)

NPD:	112957848(MEP1B)

TGT:	104576541(MEP1B)

DNE:	112994919(MEP1B)

SCAM:

104149447(MEP1B)

ASN:	102371434(MEP1B)

AMJ:	102574106(MEP1B)

CPOO:

109314699(MEP1B)

GGN:	109304248(MEP1B)

PSS:	102456515(MEP1B)

CMY:

102938685

CCAY:

125632410(MEP1B)

DCC:

119851151

CPIC:

101930949(MEP1B)

TST:	117871643(MEP1B)

CABI:

116816221(MEP1B)

MRV:	120398349(MEP1B)

ACS:	100563868(mep1b)

ASAO:

132773492(MEP1B)

PVT:	110077651(MEP1B)

SUND:

121929122(MEP1B)

PBI:	103049257(MEP1B)

VKO:	123020526(MEP1B)

PMUA:

114600650(MEP1B)

PRAF:

128417514(MEP1B)

ZVI:	118089951(MEP1B)

HCG:	128323220(MEP1B)

GJA:	107113251(MEP1B)

STOW:

125439438(MEP1B)

EMC:	129333368(MEP1B)

XLA:	108695280(mep1b.S) 108718576 108718577 108718578 108718579

XTR:	100124942(mep1b)

NPR:	108786081(MEP1B) 108786082 108786083

RTEM:

120940955 120940956

BBUF:

121002163 121002434 121002435

BGAR:

122938859(MEP1B) 122939334 122939336

MUO:	115460353(MEP1B)

GSH:	117355374(MEP1B)

DRE:	100151009(mep1ba) 327586(si:ch73-40a17.3)

SRX:	107714661 107714662 107723382 107725789

SANH:

107657610 107662546 107677797 107687173

SGH:	107563077 107568554 107571855 107581493 107581508 107596174

CCAR:

109055310 109057735 109091953 109098231 109098394 109105388 109107094 109111380 109112295

CAUA:

113039431 113059708 113060240 113063711 113084155 113084156 113084159 113102986 113102988 113102990 113113425 113116738 113119132 113121069

CGIB:

127942016 127956316 127974745 127975846 127979574 127983492 127983865 127983867 127983868 127983871 128022056 128026880 128030206

PTET:

122325166(mep1ba) 122332427 122360651 122360653

LROH:

127157649 127161025 127161026 127161027 127161028 127173169(mep1bb) 127176050 127176406 127178108 127178109 127178594 127183131(mep1ba)

OMC:	131522187(mep1bb) 131522524 131527746 131552940

PPRM:

120468741 120468742 120478367 120478369 120478370 120484792 120494197(mep1ba)

RKG:	130070081 130096146(mep1ba) 130099129(mep1bb) 130101841

MAMB:

125243202 125243203 125243205 125246280 125250500(mep1bb)

CIDE:

127497446 127497448 127502172 127502868 127511195

MASI:

127416437 127442172 127453550 127454566

TROS:

130550773 130554838(mep1bb) 130558116 130564641 130565695 130566089

TDW:	130413226 130413227 130418215(mep1bb) 130429090 130433104 130434564 130434574(mep1ba) 130434583

MANU:

129429901(mep1ba) 129441463(mep1bb) 129447967 129449196

IPU:	108258155(mep1ba) 108267869 108267871 128633049

IFU:	128601590(mep1ba) 128610426(mep1bb)

PHYP:

113545303 113547251 113547287

SMEO:

124376696(mep1ba) 124387068(mep1bb)

TFD:	113662331(mep1bb) 113664000(mep1ba)

TVC:	132843364(mep1ba) 132849002(mep1bb)

AMEX:

103035096 103045306(mep1b) 103047091 103047392

CMAO:

118815477(mep1b) 118823472 118823484 118823499 118823506 118825753(si:ch73-40a17.3)

EEE:	113582970(mep1b)

CHAR:

105896366 105896370 105896371 105898499(mep1bb) 105899696 105899698 105903742(mep1ba) 105910604 105910605 116218097 116218332 116222351 122128500 122133283

TRU:	101073548 101077603

TFS:	130528555 130538565

TNG:	GSTEN00006435G001 GSTEN00012197G001 GSTEN00020417G001 GSTEN00028305G001

LCO:	104929464 104931537(mep1b) 104939568 104939807 109140401

NCC:	104947934(mep1b)

TBEN:

117474579 117474588 117474605 117474612 117474767 117488408 117490957(mep1b)

CGOB:

115020985 115022332

PGEO:

117460687 117462588(si:ch73-40a17.3)

GACU:

117545949(mep1b) 117557838 117557886 117558338(si:ch73-40a17.3)

EMAC:

134861352 134861620 134861682 134866044(mep1bb) 134869893(mep1ba)

ELY:	117253373 117253635 117253862 117264509 117265345 117266095 117271857(si:ch73-40a17.3)

EFO:	125882232 125893314 125895297(mep1ba) 125896421 125896422 125902215(mep1bb)

PLEP:

121938414(mep1bb) 121941335 121945197

SLUC:

116039641 116046032(si:ch73-40a17.3)

ECRA:

117953861(si:ch73-40a17.3)

ESP:	116695328 116698780(mep1b)

PFLV:

114545668 114565580(mep1b) 114573819 114573835

GAT:	120810384 120811183 120815780 120823774

PPUG:

119197311 119209164(si:ch73-40a17.3) 119216184(mep1b)

AFB:	129088828 129109323

CLUM:

117729863 117746324

PSWI:

130193575(mep1ba) 130198447(mep1bb)

MSAM:

119887102 119887252 119901238 119901240 119901373 119902973

SCHU:

122877565 122887416(mep1bb)

CUD:	121512490(mep1ba) 121514163 121514164 121519949(mep1bb)

ALAT:

119005322 119006195 119010835(si:ch73-40a17.3) 119028193

MZE:	101464784 101470468(mep1b) 101487076 106674862

ONL:	100696060 100696326 100699674 100705643(mep1b) 100706112 102075759 102080243

OAU:	116309517 116309518 116309519 116309947(mep1ba) 116313761 116318670(mep1bb) 120442723

OLA:	101158971 101167239(mep1b) 101167821 101169582 101173215 105355982 105357310

OML:	112138238 112143593 112143793 112143796 112147067(si:ch73-40a17.3) 112150446 118599840

CSAI:

133436410 133440625 133452763(mep1bb)

XMA:	102225947(mep1b) 102233350 102236284 106699905

XCO:	114139666 114141730 114142354 114146571(mep1b) 114151483

XHE:	116716359 116716808 116716810 116717206 116721700(mep1b) 116726251

PRET:

103464018 103477874 103477902 103477905 103479550(mep1b)

PFOR:

103135811(mep1b) 103139244 103139245 103139249 103139250 103141591 103143062 103146697

PLAI:

106938467 106948617(mep1b) 106959843 106960215 106960224 106960439

PMEI:

106908512 106910742 106912957 106917662 106917670 106917671 106917675 106925930(mep1b)

GAF:	122830739 122831136 122831277 122838892 122841237(mep1bb)

PPRL:

129361802(mep1bb) 129370787 129370788 129370814 129370815

CVG:	107082956 107082992 107082993 107083563 107091700 107092415(mep1b)

CTUL:

119777433 119777434 119777435 119787670(mep1b) 119795659(si:ch73-40a17.3) 119797871

GMU:	124866050 124866085 124866137 124869902(mep1bb)

NFU:	107379407 107379683 107383911(mep1b)

KMR:	108235358 108235371 108235372 108235373 108235546 108235548 108239650(si:ch73-40a17.3)

ALIM:

106532705(mep1b)

NWH:	119409678 119409679 119414561(mep1bb)

AOCE:

111564199 111568694(mep1b)

MCEP:

125009142 125009184 125009186 125009187 125009188 125010423(mep1bb) 125015817 125016027 125016492 125016949 125016950 125016951 125016952

CSEM:

103389008 103396279(mep1b) 103398781

POV:	109625364 109633072 109633167 109638837 109648090

SSEN:

122759880 122766408 122769155(mep1bb) 122780674

HHIP:

117759756(mep1b) 117776987 117776988 117778189(si:ch73-40a17.3)

HSP:	118113559 118113878 118118073(mep1bb) 118121443

SMAU:

118310775(mep1bb) 118312654 118318867(mep1ba)

LCF:	108878817 108883415(mep1bb) 108898236

SDU:	111231107(mep1b) 111231912 111232045 111235801 111236058

SLAL:

111651130 111657249 111670483(mep1b) 111671975

XGL:	120784491 120798892(mep1bb)

HCQ:	109521233(mep1b)

SSCV:

125984780

SBIA:

133510868(mep1bb)

PEE:	133411179(mep1bb)

PTAO:

133489513(mep1bb)

BPEC:

110159506(mep1b) 110174420 110174421 110174422 110174423

MALB:

109954644 109954645 109957740

BSPL:

114845085(mep1bb)

SJO:	128366237 128366239 128369653(mep1bb)

SASA:

106569161(mep1b) 106605693 106605695

STRU:

115157135 115158625 115183202 115183212 115183265

OTW:	112235283 112251615(mep1ba) 112260582(mep1bb)

OMY:	110524649(mep1b) 110530435(si:ch73-40a17.3)

OGO:	123997327 124009135(mep1bb)

ONE:	115114525(mep1b) 115142125

OKI:	109875230 109881764

OKE:	118375772 118384448(mep1ba) 118402004(mep1bb)

SALP:

111956379(mep1b) 112081000

SNH:	120047228 120054335(mep1b) 120055310(si:ch73-40a17.3)

CCLU:

121533893(mep1ba) 121535317(mep1bb) 121543802 121586152

ELS:	105018582 105024313 105026400

SFM:	108937645(mep1b)

PKI:	111845993(mep1b)

AANG:

118225776(mep1b) 118233073

LOC:	102698182(mep1b)

PSPA:

121309460

ARUT:

117399984

PSEX:

120529862

LCM:	102349308(MEP1B)

CMK:

103191077

RTP:

109932190

CPLA:

122548827(mep1ba)

HOC:	132815256(mep1ba)

LERI:

129696433(mep1ba)

PMRN:

116941477(MEP1B)

LRJ:	133344322(MEP1B)

BFO:

118428956

BBEL:

109472514 109481933 109485440

CIN:	100175318 100179459

SCLV:

120326385 120335019 120335037 120337642

BTAB:

109042629 109042937

DCI:

103519147

CLEC:

106668216

NLU:	111043633 111045362

FOC:

113209580

TPAL:

117646662

ZNE:

110830837

CSEC:

111867104

PJA:	122260941 122263524 122264039

PCHN:

125028342

PCLA:

123774647

PPOI:

119091472 119095627 119095634

CSCU:

111637773

PTEP:

107446799 122268285

LPOL:

106459179

LGI:	LOTGIDRAFT_194410

PCAN:

112573791

GAE:

121380046

HRF:	124130203 124137440 124137450 124137456 124139988 124140252

HRJ:

124266673

CRG:	105317110 105317922 105319685 105319686 105319688 105343632 117683148

CVN:	111118165 111120811 111121702 111121703

CANU:

128166643

OED:	125646840 125664651 125671866

MYI:	110441919 110452104

PMAX:

117332549 117338499 117342714

MMER:

123534631 123563485 123564247 123564248

OBI:	106867426 106872752

OSN:

118764515

LAK:

106174443

NVE:	5500840 5504038 5507767 5516561 5522136 5522147

EPA:	110232881 110232943 110233649 110235540 110236447 110236451 110239576 110243849 110252250 110252268 110253148 110253171 110254049

ATEN:

116287249 116289314 116290639 116293897 116299167 116302414 116303370 116306718 116308851

ADF:	107327597 107331556 107337681 107337762 107346411 107355954

AMIL:

114955870 114956355 114957630 114958349 114965731 114968599

PDAM:

113665203 113667219 113667374 113667665 113680043 113680631 113685877 113685879

SPIS:

111325461 111326164 111330142 111330143 111336311 111337192 111337305 111345792 111345983

DGT:	114518108 114525564 114541320

HMG:	100199496 100209222

HSY:

130649463

» show all

Reference

1 [PMID:1894622]

Authors

Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.

Title

Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.

Journal

J Biol Chem 266:17350-7 (1991)

Sequence

[mmu:17288]

Reference

2 [PMID:8407940]

Authors

Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.

Title

Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.

Journal

J Biol Chem 268:21035-43 (1993)

Sequence

[mmu:17288]

Reference

3 [PMID:7510289]

Authors

Johnson GD, Hersh LB.

Title

Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.

Journal

J Biol Chem 269:7682-8 (1994)

Reference

4 [PMID:7674930]

Authors

Wolz RL, Bond JS.

Title

Meprins A and B.

Journal

Methods Enzymol 248:325-45 (1995)
DOI:10.1016/0076-6879(95)48022-6

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.63

IUBMB Enzyme Nomenclature:

3.4.24.63

ExPASy - ENZYME nomenclature database:

3.4.24.63

BRENDA, the Enzyme Database:

3.4.24.63

CAS:	150679-52-0

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3D Structure (4)   
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