KEGG   ENZYME: 3.4.24.65
Entry
EC 3.4.24.65                Enzyme                                 
Name
macrophage elastase;
metalloelastase;
human macrophage metalloelastase (HME)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of soluble and insoluble elastin [1]. Specific cleavages are also produced at -Ala14!Leu- and -Tyr16!Leu- in the B chain of insulin [2]
Comment
This enzyme is synthesized as a proenzyme of 53 kDa that is converted to an active form of 22 kDa. cDNA sequences have been obtained for the mouse [3] and human [4] enzymes. In peptidase family M10 (interstitial collagenase family)
History
EC 3.4.24.65 created 1995
Orthology
K01413  matrix metalloproteinase-12 (macrophage elastase)
Genes
HSA: 4321(MMP12)
PTR: 451512(MMP12)
PPS: 100994913(MMP12)
GGO: 101133109(MMP12)
PON: 100462632(MMP12)
NLE: 100584628(MMP12)
HMH: 116477421(MMP12)
MCC: 703867(MMP12)
MCF: 102143437(MMP12)
MTHB: 126935443
MNI: 105493705(MMP12)
CSAB: 103248345(MMP12)
CATY: 105588769(MMP12)
PANU: 101001832(MMP12)
TGE: 112606410(MMP12)
MLEU: 105542746(MMP12)
RRO: 104674669(MMP12)
RBB: 108514065(MMP12)
TFN: 117079899(MMP12)
PTEH: 111540076(MMP12)
CANG: 105500947(MMP12)
CJC: 100396585(MMP12)
SBQ: 101050929(MMP12)
CIMI: 108315435(MMP12)
CSYR: 103277139(MMP12)
MMUR: 105874592(MMP12)
LCAT: 123641001(MMP12)
PCOQ: 105822233(MMP12)
OGA: 100952334(MMP12)
MMU: 17381(Mmp12)
MCAL: 110301354(Mmp12)
MPAH: 110327207(Mmp12)
RNO: 117033(Mmp12)
MCOC: 116072035(Mmp12)
ANU: 117699744(Mmp12)
MUN: 110558091(Mmp12)
CGE: 100754279(Mmp12)
MAUA: 106021702(Mmp12)
PROB: 127233588(Mmp12)
PLEU: 114708016(Mmp12)
MORG: 121451915(Mmp12)
MFOT: 126493290
AAMP: 119810350
NGI: 103731687(Mmp12)
HGL: 101716268(Mmp12)
CPOC: 100730930(Mmp12)
CCAN: 109689284(Mmp12)
DORD: 105980878(Mmp12)
DSP: 122110379(Mmp12)
PLOP: 125349682(Mmp12)
NCAR: 124958950
MMMA: 107146001(Mmp12)
OCU: 100009559(MMP12)
TUP: 102488657(MMP12)
GVR: 103581141 103600376(MMP12)
CFA: 611789(MMP12)
CLUD: 112671437(MMP12)
VVP: 112925878(MMP12)
VLG: 121500395(MMP12)
NPO: 129497465(MMP12)
AML: 100481430(MMP12)
UMR: 103662451(MMP12)
UAH: 113260134(MMP12)
UAR: 123792504(MMP12)
ELK: 111153871
LLV: 125078731
MPUF: 101688224(MMP12)
MNP: 132029142(MMP12)
MLK: 131834662(MMP12)
NVS: 122913959(MMP12)
ORO: 101370778(MMP12)
EJU: 114211429(MMP12)
ZCA: 113914469(MMP12)
MLX: 118013057(MMP12)
NSU: 110586232(MMP12)
LWW: 102734896(MMP12)
FCA: 101084472(MMP12)
PYU: 121020791(MMP12)
PCOO: 112866155(MMP12)
PBG: 122482472(MMP12)
PVIV: 125147196(MMP12)
LRUF: 124505541
PTG: 102969995(MMP12)
PPAD: 109257538(MMP12)
PUC: 125910755
AJU: 106976504
HHV: 120223084(MMP12)
BTA: 526981(MMP12)
BOM: 102287756(MMP12)
BIU: 109569210(MMP12)
BBUB: 102412722(MMP12)
BBIS: 104987809(MMP12)
CHX: 102170339(MMP12)
OAS: 101119157(MMP12)
BTAX: 128060505(MMP12)
ODA: 120876147(MMP12)
CCAD: 122449817(MMP12)
MBEZ: 129553538(MMP12)
SSC: 100101475(MMP12)
CFR: 102520612(MMP12)
CBAI: 105067593(MMP12)
CDK: 105087167(MMP12)
VPC: 102539497(MMP12)
BACU: 103015358(MMP12)
BMUS: 118899074
LVE: 103089572
PCAD: 102984070
ECB: 100069047(MMP12)
EPZ: 103552638(MMP12)
EAI: 106843109(MMP12)
MYB: 102253777(MMP12)
MYD: 102753087(MMP12)
MMYO: 118664458(MMP12)
MLF: 102431596(MMP12)
PKL: 118713777
EFUS: 103293005(MMP12)
MNA: 107532344(MMP12)
DRO: 112317526(MMP12)
SHON: 118975668(MMP12)
AJM: 119054056(MMP12)
PDIC: 114499512 114500100
PHAS: 123805480(MMP12)
MMF: 118628311(MMP12)
PPAM: 129086098(MMP12)
HAI: 109378283
RFQ: 117030621(MMP12)
PALE: 102886383(MMP12)
PGIG: 120599671(MMP12)
PVP: 105297438(MMP12)
RAY: 107504654(MMP12)
MJV: 108391134(MMP12)
TOD: 119239979(MMP12)
SARA: 101544859(MMP12)
LAV: 100660591(MMP12)
TMU: 101341017
ETF: 101655256
DNM: 101446911(MMP12)
MDO: 100012514(MMP12)
GAS: 123241344
SHR: 100915322
AFZ: 127554926
PCW: 110214965
PRET: 103476177
LERI: 129698296
CLEC: 106669616
GAE: 121368758
OSN: 115226974
HSY: 130644367
 » show all
Reference
1  [PMID:7030312]
  Authors
Banda MJ, Werb Z.
  Title
Mouse macrophage elastase. Purification and characterization as a metalloproteinase.
  Journal
Biochem J 193:589-605 (1981)
DOI:10.1042/bj1930589
Reference
2  [PMID:7032505]
  Authors
Kettner C, Shaw E, White R, Janoff A.
  Title
The specificity of macrophage elastase on the insulin B-chain.
  Journal
Biochem J 195:369-72 (1981)
DOI:10.1042/bj1950369
Reference
3  [PMID:1537850]
  Authors
Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ.
  Title
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.
  Journal
J Biol Chem 267:4664-71 (1992)
  Sequence
[mmu:17381]
Reference
4  [PMID:8226919]
  Authors
Shapiro SD, Kobayashi DK, Ley TJ
  Title
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.
  Journal
J Biol Chem 268:23824-9 (1993)
  Sequence
[hsa:4321]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.65
IUBMB Enzyme Nomenclature: 3.4.24.65
ExPASy - ENZYME nomenclature database: 3.4.24.65
BRENDA, the Enzyme Database: 3.4.24.65
CAS: 9004-06-2

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