KEGG ENZYME: 3.4.24.72

ENZYME: 3.4.24.72

Entry

EC 3.4.24.72                Enzyme

Name

fibrolase;
fibrinolytic proteinase;
Agkistrodon contortrix contortrix metalloproteinase;
Agkistrodon contortrix contortrix venom metalloproteinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Hydrolysis of -Ala14!Leu- in insulin B chain and -Lys413!Leu- in Aalpha-chain of fibrinogen

Comment

A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake (Agkistrodon contortix contortix). In peptidase family M12 (astacin family)

History

EC 3.4.24.72 created 1996

Reference

1 [PMID:3232124]

Authors

Retzios AD, Markland FS Jr.

Title

A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems.

Journal

Thromb Res 52:541-52 (1988)
DOI:10.1016/0049-3848(88)90127-2

Reference

2 [PMID:1898066]

Authors

Guan AL, Retzios AD, Henderson GN, Markland FS Jr.

Title

Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix).

Journal

Arch Biochem Biophys 289:197-207 (1991)
DOI:10.1016/0003-9861(91)90462-R

Reference

3 [PMID:1304358]

Authors

Randolph A, Chamberlain SH, Chu HL, Retzios AD, Markland FS Jr, Masiarz FR.

Title

Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom.

Journal

Protein Sci 1:590-600 (1992)
DOI:10.1002/pro.5560010505

Reference

4 [PMID:7719479]

Authors

Loayza SL, Trikha M, Markland FS, Riquelme P, Kuo J.

Title

Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities.

Journal

J Chromatogr B Biomed Appl 662:227-43 (1994)
DOI:10.1016/0378-4347(94)00202-9

Reference

5 [PMID:8085237]

Authors

Retzios AD, Markland FS.

Title

Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin.

Journal

Thromb Res 74:355-67 (1994)
DOI:10.1016/0049-3848(94)90151-1

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.72

IUBMB Enzyme Nomenclature:

3.4.24.72

ExPASy - ENZYME nomenclature database:

3.4.24.72

BRENDA, the Enzyme Database:

3.4.24.72

CAS:	116036-70-5

All links

Protein sequence (7)   
   UniProt (5)   
   SWISS-PROT (2)   
DNA sequence (3)   
   GenBank (3)   
Protein domain (4)   
   InterPro (3)   
   PROSITE(DOC) (1)   
All databases (14)   

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