KEGG   ENZYME: 3.4.24.75
Entry
EC 3.4.24.75                Enzyme                                 
Name
lysostaphin;
glycyl-glycine endopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of the -Gly!Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans
Comment
A zinc-dependent, 25-kDa endopeptidase from Staphylococcus simulans. Lyses cells of S. aureus, in particular, by its action on the cross-bridges of the cell wall. Type example of peptidase family M23.
History
EC 3.4.24.75 created 1997
Orthology
K08259  lysostaphin
Genes
SAUSA0265(lytM)
SAVSAV0276(lytM)
SAWSAHV_0274(lytM)
SAHSaurJH1_0267
SAJSaurJH9_0260
SAMMW0252(lytM)
SASSAS0252
SARSAR0273(lytM)
SACSACOL0263(lytM)
SAXUSA300HOU_0289(lytM)
SAASAUSA300_0270(lytM)
SAOSAOUHSC_00248
SADSAAV_0244(lytM)
SUUM013TW_0257(lytM)
SUVSAVC_01125
SUESAOV_0217(lytM)
SUJSAA6159_00254(lytM)
SUKSAA6008_00250
SUCECTR2_237
SUTSAT0131_00271
SUQHMPREF0772_10224(lytM)
SUZMS7_0267(lytM)
SUDST398NM01_0291
SUXSAEMRSA15_02350(lytM)
SUWSATW20_02780(lytM)
SUGSAPIG0291
SUFSARLGA251_02400(lytM)
SAUASAAG_00758
SAUERSAU_000222(lytM)
SAUNSAKOR_00256
SAUSSA40_0234(lytM)
SAUUSA957_0249(lytM)
SAUGSA268_0246(lytM)
SAUZSAZ172_0279(lytM)
SAUTSAI1T1_2002140(lytM)
SAUJSAI2T2_1002140(lytM)
SAUKSAI3T3_1002140(lytM)
SAUQSAI4T8_1002140(lytM)
SAUVSAI7S6_1002140
SAUWSAI5S5_1002130
SAUXSAI6T6_1002140
SAUYSAI8T7_1002140
SAUFX998_0253(lytM)
SABSAB0215(lytM)
SUYSA2981_0276(lytM)
SAUBC248_0266(lytM)
SAUMBN843_2760
SAUCCA347_282(lytM)
SAURSABB_01575(lytM)
SAUIAZ30_01395
SAUDCH52_04340
SAMSNI36_01285
SUHSAMSHR1132_02420
SCASCA_2377(lytM)
SDPNCTC12225_00117(lytM_1)
SXYBE24_11170
SXLSXYLSMQ121_0184
SXOSXYL_00180
SHUSHYC_11995(lytM)
SAGQEP23_10125
SCHRDWB92_12035
SARLSAP2_02690
SPICSAMEA4384060_0108(lytM)
SSHNCTC13712_00221(lytM)
SSIMSAMEA4384339_0242(lytM_2)
SDBCNQ82_01540
SRAILN051_11305
SPSDJMB28_01460
SEDAMNY58_01020
SCAQQMO72_00270
SROTML435_01185
STAPAOB58_1990
SSCUCEP64_12725
SSTESAMEA4384403_0153(lytM)
MLENH3V22_08695
MBRUMGG13_03400
MBOCQSV55_03310
 » show all
Reference
1  [PMID:3547405]
  Authors
Recsei PA, Gruss AD, Novick RP
  Title
Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans.
  Journal
Proc Natl Acad Sci U S A 84:1127-31 (1987)
DOI:10.1073/pnas.84.5.1127
  Sequence
Reference
2  [PMID:8890152]
  Authors
Baba T, Schneewind O.
  Title
Target cell specificity of a bacteriocin molecule: a C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus.
  Journal
EMBO J 15:4789-97 (1996)
DOI:10.1002/j.1460-2075.1996.tb00859.x
Reference
3  [PMID:9106216]
  Authors
Thumm G, Gotz F
  Title
Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus.
  Journal
Mol Microbiol 23:1251-65 (1997)
DOI:10.1046/j.1365-2958.1997.2911657.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.75
IUBMB Enzyme Nomenclature: 3.4.24.75
ExPASy - ENZYME nomenclature database: 3.4.24.75
BRENDA, the Enzyme Database: 3.4.24.75
CAS: 9011-93-2

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