KEGG ENZYME: 3.4.24.82

ENZYME: 3.4.24.82

Entry

EC 3.4.24.82                Enzyme

Name

ADAMTS-4 endopeptidase;
aggrecanase-1

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373!Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan

Comment

In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.

History

EC 3.4.24.82 created 2003

Orthology

K07764

a disintegrin and metalloproteinase with thrombospondin motifs 4

Genes

HSA:	9507(ADAMTS4)

PTR:	457453(ADAMTS4)

PPS:	100978654(ADAMTS4)

GGO:	101151733(ADAMTS4)

PON:	100461178(ADAMTS4)

NLE:	100606067(ADAMTS4)

HMH:	116473341(ADAMTS4)

MCC:	719927(ADAMTS4)

MCF:	102120792(ADAMTS4)

MTHB:

126935690

MNI:	105498207(ADAMTS4)

CSAB:

103223687(ADAMTS4)

CATY:

105589250(ADAMTS4)

PANU:

101001940(ADAMTS4)

TGE:	112629310(ADAMTS4)

MLEU:

105536729(ADAMTS4)

RRO:	104665341(ADAMTS4)

RBB:	108521183(ADAMTS4)

TFN:	117076372(ADAMTS4)

PTEH:

111543905(ADAMTS4)

CANG:

105522938(ADAMTS4)

CJC:	100409334(ADAMTS4)

SBQ:	101049525(ADAMTS4)

CIMI:

108293609(ADAMTS4)

CSYR:

103260251(ADAMTS4)

MMUR:

105873548(ADAMTS4)

LCAT:

123635219(ADAMTS4)

PCOQ:

105806435(ADAMTS4)

OGA:	100949534(ADAMTS4)

MMU:	240913(Adamts4)

MCAL:

110300072(Adamts4)

MPAH:

110321549(Adamts4)

RNO:	66015(Adamts4)

MCOC:

116103348(Adamts4)

ANU:	117721509(Adamts4)

MUN:	110554422(Adamts4)

CGE:	100773045(Adamts4)

MAUA:

101836864(Adamts4)

PROB:

127223567(Adamts4)

PLEU:

114685429(Adamts4)

MORG:

121442028 121454872

MFOT:

126502201

AAMP:

119827485(Adamts4)

NGI:	103745952(Adamts4)

HGL:	101702362(Adamts4)

CPOC:

100712995(Adamts4)

CCAN:

109693206(Adamts4)

DORD:

105996477(Adamts4)

DSP:	122109573(Adamts4)

PLOP:

125359740(Adamts4)

NCAR:

124994744

MMMA:

107147473(Adamts4)

OCU:

100008765

OPI:	101516362(ADAMTS4)

TUP:	102502349(ADAMTS4)

GVR:	103596555(ADAMTS4)

CFA:	488651(ADAMTS4)

CLUD:

112643022(ADAMTS4)

VVP:	112910058(ADAMTS4)

VLG:	121471391(ADAMTS4)

NPO:	129515414(ADAMTS4)

AML:	100482466(ADAMTS4)

UMR:	121103642(ADAMTS4)

UAH:	113246716(ADAMTS4)

UAR:	123783502(ADAMTS4)

ELK:

111138960

LLV:

125085764

MPUF:

101674803(ADAMTS4)

MNP:	132025756(ADAMTS4)

MLK:	131814322(ADAMTS4)

NVS:	122918372(ADAMTS4)

ORO:	101367478(ADAMTS4)

EJU:	114199118(ADAMTS4)

ZCA:	113932200(ADAMTS4)

MLX:	118014014(ADAMTS4)

NSU:	110573391(ADAMTS4)

LWW:	102735426(ADAMTS4)

FCA:	101089488(ADAMTS4)

PYU:	121015473(ADAMTS4)

PBG:	122476197(ADAMTS4)

PVIV:

125155122(ADAMTS4)

LRUF:

124521829

PTG:	107180621(ADAMTS4)

PPAD:

109257264(ADAMTS4)

PUC:

125925574

AJU:

106978552

HHV:	120241406(ADAMTS4)

BTA:	286806(ADAMTS4)

BOM:	102273858(ADAMTS4)

BIU:	109556672(ADAMTS4)

BBUB:

102398638(ADAMTS4)

BBIS:

104984068(ADAMTS4)

CHX:	102176281(ADAMTS4)

OAS:	101106565(ADAMTS4)

BTAX:

128044803(ADAMTS4)

ODA:	120855546(ADAMTS4)

CCAD:

122430422(ADAMTS4)

MBEZ:

129541390(ADAMTS4)

SSC:	100157276(ADAMTS4)

CFR:	102524038(ADAMTS4)

CBAI:

105069550(ADAMTS4)

CDK:	105100107(ADAMTS4)

VPC:	102529810(ADAMTS4)

BACU:

103013314(ADAMTS4)

BMUS:

118884152(ADAMTS4)

LVE:	103084640(ADAMTS4)

OOR:	101277647(ADAMTS4)

DLE:	111166989(ADAMTS4)

PCAD:

102990465(ADAMTS4)

PSIU:

116754843(ADAMTS4)

NASI:

112408111(ADAMTS4)

ECB:	100033914(ADAMTS4)

EPZ:	103560005(ADAMTS4)

EAI:	106827590(ADAMTS4)

MYB:	102261845(ADAMTS4)

MYD:	102773999(ADAMTS4)

MMYO:

118672884(ADAMTS4)

MLF:	102417781(ADAMTS4)

PKL:	118716884(ADAMTS4)

EFUS:

103296545(ADAMTS4)

MNA:	107535095(ADAMTS4)

DRO:	112297288(ADAMTS4)

SHON:

118979087(ADAMTS4)

AJM:	119052587(ADAMTS4)

PDIC:

114489425(ADAMTS4)

PHAS:

123818337(ADAMTS4)

MMF:	118637298(ADAMTS4)

PPAM:

129082089(ADAMTS4)

HAI:	109376933(ADAMTS4)

RFQ:	117014405(ADAMTS4)

PALE:

102897169(ADAMTS4)

PGIG:

120584201(ADAMTS4)

PVP:	105303395(ADAMTS4)

RAY:	107504676(ADAMTS4)

MJV:	108389436(ADAMTS4)

TOD:	119241371(ADAMTS4)

SARA:

101556095(ADAMTS4)

SETR:

126013973(ADAMTS4)

LAV:	100654431(ADAMTS4)

TMU:

101348576

ETF:	101658222(ADAMTS4)

DNM:	101412811(ADAMTS4)

MDO:	100032755(ADAMTS4)

GAS:	123247041(ADAMTS4)

SHR:	100922734(ADAMTS4)

AFZ:

127562485

PCW:	110197935(ADAMTS4)

OAA:	100091824(ADAMTS4)

GGA:	100858999(ADAMTS4)

PCOC:

116239316(ADAMTS4)

MGP:	104914443(ADAMTS4)

NMEL:

110387861(ADAMTS4)

APLA:

119715358(ADAMTS4)

ACYG:

125181611(ADAMTS4)

CATA:

118260494(ADAMTS4)

FPG:	101924861(ADAMTS4)

FCH:	102058101(ADAMTS4)

NNI:	104012592(ADAMTS4)

TALA:

116964872 122152498

AFOR:

103900551(ADAMTS4)

ACHC:

115345594(ADAMTS4)

HLE:	104831381(ADAMTS4)

AGEN:

126040740

SHAB:

115602631(ADAMTS4)

RTD:	128900938(ADAMTS4) 128900967

AAM:	106500493(ADAMTS4)

AROW:

112972507(ADAMTS4)

NPD:	112950645(ADAMTS4)

DNE:	112990074(ADAMTS4)

ASN:	102388568(ADAMTS4)

AMJ:	102559465(ADAMTS4)

PSS:	102460656(ADAMTS4)

CMY:	102936762(ADAMTS4)

CCAY:

125625984(ADAMTS4)

DCC:	119847900(ADAMTS4)

CPIC:

101953033(ADAMTS4)

TST:	117869550(ADAMTS4)

CABI:

116816121(ADAMTS4)

MRV:	120390689(ADAMTS4)

ACS:	100559101(adamts4)

ASAO:

132764343(ADAMTS4)

PVT:	110081061(ADAMTS4)

SUND:

121916117(ADAMTS4)

PBI:	103062930(ADAMTS4)

PMUR:

107299416(ADAMTS4)

CTIG:

120317068(ADAMTS4)

TSR:	106538154(ADAMTS4)

PGUT:

117659994(ADAMTS4)

APRI:

131186553(ADAMTS4)

PTEX:

113446588(ADAMTS4)

VKO:	123032657(ADAMTS4)

PMUA:

114586262(ADAMTS4)

PRAF:

128403628(ADAMTS4)

ZVI:	118075820(ADAMTS4)

HCG:	128337202(ADAMTS4)

GJA:	107121742(ADAMTS4)

STOW:

125436680(ADAMTS4)

EMC:	129339314(ADAMTS4)

XLA:	108699607(adamts4.L) 108700401(adamts4.S)

XTR:	100487641(adamts4)

NPR:	108802055(ADAMTS4)

RTEM:

120920968(ADAMTS4)

BBUF:

120982343(ADAMTS4)

BGAR:

122921716(ADAMTS4)

MUO:	115458391(ADAMTS4)

GSH:	117350222(ADAMTS4)

LCM:	102354523(ADAMTS4)

LHU:

105680045

» show all

Reference

1 [PMID:11854269]

Authors

Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD.

Title

ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.

Journal

J Biol Chem 277:16059-66 (2002)
DOI:10.1074/jbc.M108607200

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.82

IUBMB Enzyme Nomenclature:

3.4.24.82

ExPASy - ENZYME nomenclature database:

3.4.24.82

BRENDA, the Enzyme Database:

3.4.24.82

CAS:	147172-61-0

DBGET integrated database retrieval system