KEGG   ENZYME: 3.5.1.100
Entry
EC 3.5.1.100                Enzyme                                 
Name
(R)-amidase;
R-stereospecific amidase;
R-amidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
(R)-piperazine-2-carboxamide amidohydrolase
Reaction(IUBMB)
(1) (R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH3 [RN:R09647];
(2) beta-alaninamide + H2O = beta-alanine + NH3 [RN:R09648]
Reaction(KEGG)
R09647 R09648
Substrate
(R)-piperazine-2-carboxamide [CPD:C19778];
H2O [CPD:C00001];
beta-alaninamide [CPD:C19779]
Product
(R)-piperazine-2-carboxylate [CPD:C19780];
NH3 [CPD:C00014];
beta-alanine [CPD:C00099]
Comment
In addition (R)-piperidine-3-carboxamide is hydrolysed to (R)-piperidine-3-carboxylic acid and NH3, and (R)-N-tert-butylpiperazine-2-carboxamide is hydrolysed to (R)-piperazine-2-carboxylic acid and tert-butylamine with lower activity. The enzyme does not act on the other amide substrates which are hydrolysed by EC 3.5.1.4 (amidase).
History
EC 3.5.1.100 created 2009, modified 2011
Orthology
K18540  (R)-amidase
Genes
SLQM495_09540
SFWWN53_23135
SFGAV650_18940
PAEPA3598
PAEVN297_3722(ramA)
PAEIN296_3722(ramA)
PAUPA14_17730
PAPPSPA7_1543
PAGPLES_14371
PAFPAM18_1387
PNCNCGM2_4729
PAEBNCGM1900_2679
PDKPADK2_06350
PSGG655_06805
PRPM062_19050
PAEPPA1S_07420
PAERPA1R_gp1417
PAEMU769_06900
PAELT223_07135
PAESSCV20265_1459
PAEUBN889_03983
PAEGAI22_26485
PAECM802_3719(ramA)
PAEOM801_3587(ramA)
PREPCA10_16240
PFUWKF707C_40970
PCQPcP3B5_21760(ramA_1)
PMUIG4G71_25745
PNTG5B91_08285
PPAAB7D75_07165
PPUPP_3846(ramA)
PPGPputGB1_2588
PPTPPS_2644
PPUHB479_12805
PPUDDW66_2904
PFVPsefu_1603
PMONX969_12555
PMOTX970_12200
PPJRK21_02127
PORAPT59_07350
PMOLCLJ08_04110
PALDLU682_010930
PIXRIN61_25620
PMOSO165_014445
PFLPFL_4898
PPRCPFLCHA0_c48790(ramA)
PPROPPC_4907
PFOPfl01_4557
PMANOU5_4712
PTVAA957_08470
PAZOAYR47_12840
PTOLI7845_05540
PFXA7318_04835
PENPSEEN3582
PLULFOB45_04765
PPUUPputUW4_01010
PDRH681_06995
PKCPKB_3494(ramA)
PCHEY04_25420
PCZPCL1606_12510
PCHPC4K32_5101
PFZAV641_09915
PALKPSAKL28_32040
PSWLK03_17965
PSEMTO66_25495
PFKPFAS1_05720
PANRA7J50_1111
PSETTHL1_1666
PSILPMA3_19055
PYMAK972_0917 AK972_2857
PKEDLD99_23115
PUMHGP31_25555
POJPtoMrB4_44060
PPSHG5J76_17110
PGYAWU82_26835
PLALFXN65_11600
PKHJLK41_23925
PMAOPMYSY11_2422(ramA)
PATAJWU58_06245
PDWBV82_3432
PZEHU754_024020
PMOEHV782_023400
PVWHU752_027095
PTZHU718_024630
PXNHU772_016120
PHVHU739_023445
PAZEKSS91_05920
PALVKSS97_24420
PTKEXN22_12150
PTWTUM18999_48310
PIEHU724_022700
PWYHU734_019110
PGFJ0G10_25020
PCAVD3880_16645
PIZLAB08_R09960
PPEGKUA23_05735
PFITKJY40_24405
PASILG197_18770
PNBNK667_01415
PSOAPSm6_34730
PKJQ1W70_00975
PHOMKJF94_20945
PTRLOU419_07405
PDENF1C79_00305
CPSCPS_2030
PRRAT705_08305
PVBJ5X90_01265
CSACsal_0061
CCAGSR908_07685
HHUAR456_00330
HHAOQWG60_00240
KUYFY550_15230
TAUTola_1341
IGNMMG00_02635
SALNSALB1_0801
PSENH8B_1826
AMAHDLM_2428
AQSDKK66_14490
BVIBcep1808_1625
BVEAK36_2221(ramA)
BURBcep18194_A4513
BCMBcenmc03_1348 Bcenmc03_3529 Bcenmc03_4306
BCHBcen2424_3994
BCJBCAL1380(ramA)
BCENDM39_1273(ramA)
BCEOI35_1275(ramA)
BAMBamb_1638
BMJBMULJ_03495
BMUBmul_5017
BMULNP80_1792(ramA)
BCTGEM_2060
BCEDDM42_329(ramA)
BCEPAPZ15_10660
BDLAK34_1396(ramA)
BPYRABD05_12660
BCONNL30_08850
BTEIWS51_07825
BSEMWJ12_06730
BPSLWS57_25140
BMECWJ16_06595
BSTLBBJ41_05260
BANNJFN94_06975
BARINLX30_07390
BAENL3V59_07455
BGLbglu_2g15230
BGUKS03_4414(ramA)
BGDbgla_2g09710
BGOBM43_4600(ramA)
BUKMYA_1509
BGPBGL_2c08780
BPLAbpln_2g09690
BUZAYM40_06155 AYM40_21415
BFNOI25_201
BCAIK788_0003819
PARBCJU94_17435
PHSC2L64_06765
PTERC2L65_06505
PCAFDSC91_006605
PMEGFNZ07_25755
PTROG5S35_20385
PACPFAZ97_23945
PACSFAZ98_19315
PBRYNDK50_06505
PSAAQEN71_06970
ASWCVS48_09000
ACHRC2U31_18595
DELDelCs14_5435
DTSBI380_19195
DHKBO996_05515
DLAI6G47_19105
RIDRIdsm_00233(ramA_1)
SECHB18_00975
DALKDSCA_54440
CSPGLS684_22545
NCMQNK12_03740
SFORQNH23_01270
TEIQS257_17955
ALKGMOJ78_03025
PUKPU629_13185
DCADesca_1581
ADGAdeg_1492
MSGMSMEI_6550
MSBLJ00_33265
MSNLI99_33270
MSHLI98_33275
SCYNN8I84_01835
CWOCwoe_0991
GPNPan110_34850(ramA_3)
MRIMal4_43390(ramA_5)
SACISinac_2712
AGVOJF2_67910(ramA_4)
ABACLuPra_03237(ramA_2)
SPIBG8759_26060
MEUZKRP56_07785
CMACmaq_0501
VDIVdis_2026
VMOVMUT_0433
 » show all
Reference
1  [PMID:15066183]
  Authors
Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y
  Title
A novel R-stereoselective amidase from Pseudomonas sp. MCI3434 acting on piperazine-2-tert-butylcarboxamide.
  Journal
Eur J Biochem 271:1580-90 (2004)
DOI:10.1111/j.1432-1033.2004.04069.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.100
IUBMB Enzyme Nomenclature: 3.5.1.100
ExPASy - ENZYME nomenclature database: 3.5.1.100
BRENDA, the Enzyme Database: 3.5.1.100

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