| Entry |
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| Name |
L-proline amide hydrolase;
S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase;
LaaA;
L-amino acid amidase
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
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| Sysname |
(S)-piperidine-2-carboxamide amidohydrolase
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| Reaction(IUBMB) |
(1) (S)-piperidine-2-carboxamide + H2O = (S)-piperidine-2-carboxylate + NH3 [RN: R09680];
(2) L-prolinamide + H2O = L-proline + NH3 [RN: R09650]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
(S)-piperidine-2-carboxylate;
NH3 [CPD: C00014];
L-proline [CPD: C00148]
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| History |
EC 3.5.1.101 created 2009
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| Orthology |
| K18457 | L-proline amide hydrolase |
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| Genes |
| REE: | electrica_01634(laaA) |
| RTG: | NCTC13098_04863(laaA_1) |
| XPH: | XppCFBP6546_20825(XppCFBP6546P_20825) |
| XHD: | LMG31886_13690(laaA) |
| PVD: | CFBP1590__4609(laaA) |
| PPRC: | PFLCHA0_c52700(laaA) |
| PMUD: | NCTC8068_03512(pip_3) |
| PFW: | PF1751_v1c15970(laaA) |
| PSK: | U771_09205 U771_12490 |
| TWG: | Thiowin_01482(pip_1) |
| SMEL: | SM2011_c04031(pip2) |
| REC: | RHECIAT_PC0000238(pipc2) |
| REL: | REMIM1_PA00099(laaA) |
| REP: | IE4803_PD00432(laaA) |
| REI: | IE4771_PE00449(laaA) |
| RHL: | LPU83_pLPU83d1219(laaA) |
| RGA: | RGR602_PC00694(laaA) |
| RPHA: | AMC79_PD00249(laaA) |
| SHI: | Shel_16440 Shel_21290 |
| SRW: | TUE45_pSRc_0416(laaA) |
| KUT: | JJ691_07350 JJ691_31600 |
| KBU: | Q4V64_08130 Q4V64_49225 |
| PHG: | KCTC32516_02274(pip) |
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| Reference |
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| Authors |
Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y |
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| Title |
S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.5.1.101 |
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