Entry
Name
2'''-acetyl-6'''-hydroxyneomycin C deacetylase;
neoL (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming)
Reaction(IUBMB)
2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate [RN:
R08901 ]
Reaction(KEGG)
Substrate
2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C;
H2O [CPD:
C00001 ]
Product
6'''-deamino-6'''-hydroxyneomycin C [CPD:
C17588 ];
acetate [CPD:
C00033 ]
Comment
Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC
3.5.1.112 , 2'-N-acetylparomamine deacetylase.
History
EC 3.5.1.113 created 2012
Pathway
ec00524 Neomycin, kanamycin and gentamicin biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K17078 2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase
Genes
SDD : D9753_07125 D9753_17065
Taxonomy
Reference
Authors
Yokoyama K, Yamamoto Y, Kudo F, Eguchi T
Title
Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.5.1.113