KEGG ENZYME: 3.5.2.19

ENZYME: 3.5.2.19

Entry

EC 3.5.2.19                 Enzyme

Name

streptothricin hydrolase;
sttH (gene name)

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides

Sysname

streptothricin-F hydrolase

Reaction(IUBMB)

streptothricin-F + H2O = streptothricin-F acid [RN:R09657]

Reaction(KEGG)

R09657

Substrate

streptothricin F [CPD:C19785];
H2O [CPD:C00001]

Product

streptothricin F acid [CPD:C19786]

Comment

The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2].

History

EC 3.5.2.19 created 2011

Orthology

K20816

streptothricin hydrolase

Genes

PMOL:

CLJ08_22265

PMOS:

O165_014065

PEN:

PSEEN1846

PSEC:

CCOS191_1744

PXN:	HU772_008675

PMUY:

KSS95_18535

PMAM:

KSS90_09080

PHYG:

JTY93_27880

ADS:	FPL17_05630

AGYL:

FPL18_16095

ACOI:

NQU59_12665

AVIV:

LF296_08590

PPUL:

RO07_18935

AAK:	AA2016_0202

AMIS:

Amn_05420

EAD:

OV14_3469

EAH:	FA04_10315

ECAA:

J3R84_10135

ENP:	JVX98_09295

RTR:	RTCIAT899_CH01190

RHR:	CKA34_04185

MLD:	U0023_25495

SGR:

SGR_517

SFI:

SFUL_6857

SANL:

KZO11_36125

SCYE:

R2B67_01545

SFA:

Sfla_4024

SBH:

SBI_05248

SVE:

SVEN_0767

STRP:

F750_2699

SVT:	SVTN_05300

SLC:	SL103_25620

SPRI:

SPRI_1189

SCZ:	ABE83_01585

SCLF:

BB341_03190

SALW:

CP975_32885

SNR:	SNOUR_11545(sttH)

SALL:

SAZ_31715

SNW:	BBN63_17435

SALF:

SMD44_00626

STRO:

STRMOE7_29990

SQZ:	FQU76_29045

SCAV:

CVT27_31720

SRIM:

CP984_20310

SCIN:

CP977_04795

STSU:

B7R87_29155

SGX:	H4W23_05770

SSPB:

CP982_39700

SATA:

C5746_23425

SLIA:

HA039_30130

SPEU:

CGZ69_31135

SGJ:	IAG43_27755

SHK:	J2N69_34975

STRY:

EQG64_32990

SINE:

KI385_34690

SAOV:

G3H79_35660

SDUR:

M4V62_38470

STAA:

LDH80_33635

SNIG:

HEK616_49600

STUB:

MMF93_16310

SLON:

LGI35_40150

SDRZ:

NEH16_09910

SENG:

OJ254_29540

SFIY:

F0344_10410

SLAI:

P8A22_12255

SFP:	QUY26_37410

LMOI:

VV02_21860

NAQU:

ENKNEFLB_02319(sttH)

KFL:

Kfla_2808

KQI:	F1D05_09075

KSL:	OG809_24450

NCG:	KGD84_23445

PSEE:

FRP1_29220

PHH:	AFB00_10145

PPEL:

H6H00_05060

» show all

Reference

1 [PMID:19897889]

Authors

Maruyama C, Hamano Y

Title

The biological function of the bacterial isochorismatase-like hydrolase SttH.

Journal

Biosci Biotechnol Biochem 73:2494-500 (2009)
DOI:10.1271/bbb.90499

Sequence

[ag:BAE93577 BAH84826]

Reference

2 [PMID:16641084]

Authors

Hamano Y, Matsuura N, Kitamura M, Takagi H

Title

A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific.

Journal

J Biol Chem 281:16842-8 (2006)
DOI:10.1074/jbc.M602294200

Sequence

[ag:BAE93577]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.2.19

IUBMB Enzyme Nomenclature:

3.5.2.19

ExPASy - ENZYME nomenclature database:

3.5.2.19

BRENDA, the Enzyme Database:

3.5.2.19

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (78)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (77)   
Protein sequence (520)   
   UniProt (518)   
   SWISS-PROT (2)   
DNA sequence (709)   
   GenBank (359)   
   EMBL (350)   
Protein domain (3)   
   InterPro (3)   
All databases (1315)   

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