Entry
Name
double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
double-stranded RNA adenine aminohydrolase
Reaction(IUBMB)
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3 [RN:
R13080 ]
Reaction(KEGG)
Substrate
adenine in double-stranded RNA [CPD:
C22573 ];
H2O [CPD:
C00001 ]
Product
hypoxanthine in double-stranded RNA [CPD:
C22574 ];
NH3 [CPD:
C00014 ]
Comment
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].
History
EC 3.5.4.37 created 2013
Orthology
K12968 double-stranded RNA-specific adenosine deaminase
Genes
PTEX : 113452865 113452866 113452867 113452869
XLA : 394279(adar-a) 397992(adar.S)
CAUA : 113059109 113116748
CGIB : 127974704 128030703
MASI : 127452888 127453546
NWH : 119409734(adar) 119410066
STRU : 115177204 115177266
OMY : 110520838(adar) 110534250
OKE : 118373734 118373735(adar)
PMRN : 116950849(ADAR) 116954936
LRJ : 133344079 133354150 133361043
CANU : 128176028 128176031
RPHI : 132722439 132754534
» show all
Taxonomy
Reference
Authors
Hough RF, Bass BL
Title
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.
Journal
J Biol Chem 269:9933-9 (1994)
Reference
Authors
O'Connell MA, Gerber A, Keegan LP
Title
Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.
Journal
Reference
Authors
Wong SK, Sato S, Lazinski DW
Title
Substrate recognition by ADAR1 and ADAR2.
Journal
Reference
Authors
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL
Title
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.37
ExPASy - ENZYME nomenclature database: 3.5.4.37