KEGG   ENZYME: 3.5.4.8
Entry
EC 3.5.4.8                  Enzyme                                 
Name
aminoimidazolase;
4-aminoimidazole hydrolase;
4-aminoimidazole deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
4-aminoimidazole aminohydrolase
Reaction(IUBMB)
4-aminoimidazole + H2O = imidazol-4-one + NH3 [RN:R04731]
Reaction(KEGG)
R04731
Substrate
4-aminoimidazole [CPD:C05239];
H2O [CPD:C00001]
Product
imidazol-4-one [CPD:C06195];
NH3 [CPD:C00014]
Comment
Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].
History
EC 3.5.4.8 created 1961
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13367024]
  Authors
PRICER WE Jr, RABINOWITZ JC.
  Title
Purine fermentation by Clostridium cylindrosporum.  V.  Formiminoglycine.
  Journal
J Biol Chem 222:537-54 (1956)
Reference
2
  Authors
Freter, K., Rabinowitz, J.C. and Witkop, B.
  Title
Labile Stoffwechselprodukte. V. Zur Biogenese des Formiminoglycins aus 4(5H)-imidazolon.
  Journal
Ann Chem 607:174-187 (1957)
Reference
3  [PMID:786256]
  Authors
Vogels GD, Van der Drift C.
  Title
Degradation of purines and pyrimidines by microorganisms.
  Journal
Bacteriol Rev 40:403-68 (1976)
Reference
4  [PMID:8376322]
  Authors
DeMoll E, Auffenberg T.
  Title
Purine metabolism in Methanococcus vannielii.
  Journal
J Bacteriol 175:5754-61 (1993)
DOI:10.1128/JB.175.18.5754-5761.1993
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.8
IUBMB Enzyme Nomenclature: 3.5.4.8
ExPASy - ENZYME nomenclature database: 3.5.4.8
BRENDA, the Enzyme Database: 3.5.4.8
CAS: 9025-17-6

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