Entry
Name
aminoimidazolase;
4-aminoimidazole hydrolase;
4-aminoimidazole deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
4-aminoimidazole aminohydrolase
Reaction(IUBMB)
4-aminoimidazole + H2O = imidazol-4-one + NH3 [RN:
R04731 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].
History
EC 3.5.4.8 created 1961
Pathway
Reference
Authors
PRICER WE Jr, RABINOWITZ JC.
Title
Purine fermentation by Clostridium cylindrosporum. V. Formiminoglycine.
Journal
J Biol Chem 222:537-54 (1956)
Reference
2
Authors
Freter, K., Rabinowitz, J.C. and Witkop, B.
Title
Labile Stoffwechselprodukte. V. Zur Biogenese des Formiminoglycins aus 4(5H)-imidazolon.
Journal
Ann Chem 607:174-187 (1957)
Reference
Authors
Vogels GD, Van der Drift C.
Title
Degradation of purines and pyrimidines by microorganisms.
Journal
Bacteriol Rev 40:403-68 (1976)
Reference
Authors
DeMoll E, Auffenberg T.
Title
Purine metabolism in Methanococcus vannielii.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.8
ExPASy - ENZYME nomenclature database: 3.5.4.8
BRENDA, the Enzyme Database: 3.5.4.8