Entry |
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Name |
2,6-dihydroxypseudooxynicotine hydrolase
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Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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Sysname |
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase
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Reaction(IUBMB) |
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate [RN: R07515]
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Reaction(KEGG) |
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Substrate |
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one [CPD: C15986];
H2O [CPD: C00001]
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Product |
2,6-dihydroxypyridine [CPD: C03056];
4-methylaminobutanoate
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Comment |
The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation.
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History |
EC 3.7.1.19 created 2012
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Pathway |
ec00760 | Nicotinate and nicotinamide metabolism |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K19188 | 2,6-dihydroxypseudooxynicotine hydrolase |
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Genes |
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Reference |
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Authors |
Gherna RL, Richardson SH, Rittenberg SC |
Title |
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine. |
Journal |
J Biol Chem 240:3669-74 (1965) |
Reference |
|
Authors |
Sachelaru P, Schiltz E, Igloi GL, Brandsch R. |
Title |
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 3.7.1.19 |
ExPASy - ENZYME nomenclature database: | 3.7.1.19 |
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