KEGG   ENZYME: 3.8.1.11
Entry
EC 3.8.1.11                 Enzyme                                 
Name
2-haloacid dehalogenase (configuration-retaining);
2-haloalkanoic acid dehalogenase;
2-haloalkanoid acid halidohydrolase;
DL-2-haloacid dehalogenase;
DL-DEXr
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
Sysname
(S)-2-haloacid dehalogenase (configuration-retaining)
Reaction(IUBMB)
(1) (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide [RN:R07309];
(2) (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide [RN:R07310]
Reaction(KEGG)
R07309 R07310
Substrate
(S)-2-haloacid [CPD:C02103];
H2O [CPD:C00001];
(R)-2-haloacid [CPD:C15564]
Product
(S)-2-hydroxyacid [CPD:C15565];
halide [CPD:C00462];
(R)-2-hydroxyacid [CPD:C02489]
Comment
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)]
History
EC 3.8.1.11 created 2003
Reference
1  [PMID:7142958]
  Authors
Weightman AJ, Weightman AL, Slater JH.
  Title
Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms.
  Journal
J Gen Microbiol 128:1755-62 (1982)
DOI:10.1099/00221287-128-8-1755
Reference
2
  Authors
Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N.
  Title
Bacterial 2-haloacid dehalogenases: Structures and catalytic properties.
  Journal
Pure Appl Chem 68:2097-2103 (1996)
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.11
IUBMB Enzyme Nomenclature: 3.8.1.11
ExPASy - ENZYME nomenclature database: 3.8.1.11
BRENDA, the Enzyme Database: 3.8.1.11

  All links  
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Protein sequence (1)   
   UniProt (1)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
All databases (14)   

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