KEGG ENZYME: 4.1.1.72

ENZYME: 4.1.1.72

Entry

EC 4.1.1.72                 Enzyme

Name

branched-chain-2-oxoacid decarboxylase;
branched-chain oxo acid decarboxylase;
branched-chain alpha-keto acid decarboxylase;
branched-chain keto acid decarboxylase;
BCKA;
(3S)-3-methyl-2-oxopentanoate carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)

Reaction(IUBMB)

(3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2 [RN:R03894]

Reaction(KEGG)

R03894

Substrate

(3S)-3-methyl-2-oxopentanoate [CPD:C00671]

Product

2-methylbutanal [CPD:C02223];
CO2 [CPD:C00011]

Comment

Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.

History

EC 4.1.1.72 created 1990

Reference

1 [PMID:3142877]

Authors

Oku H, Kaneda T.

Title

Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase.

Journal

J Biol Chem 263:18386-96 (1988)

Reference

2 [PMID:15358422]

Authors

de la Plaza M, Fernandez de Palencia P, Pelaez C, Requena T

Title

Biochemical and molecular characterization of alpha-ketoisovalerate decarboxylase, an enzyme involved in the formation of aldehydes from amino acids by Lactococcus lactis.

Journal

FEMS Microbiol Lett 238:367-74 (2004)
DOI:10.1016/j.femsle.2004.07.057

Reference

3 [PMID:15640202]

Authors

Smit BA, van Hylckama Vlieg JE, Engels WJ, Meijer L, Wouters JT, Smit G

Title

Identification, cloning, and characterization of a Lactococcus lactis branched-chain alpha-keto acid decarboxylase involved in flavor formation.

Journal

Appl Environ Microbiol 71:303-11 (2005)
DOI:10.1128/AEM.71.1.303-311.2005

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.72

IUBMB Enzyme Nomenclature:

4.1.1.72

ExPASy - ENZYME nomenclature database:

4.1.1.72

BRENDA, the Enzyme Database:

4.1.1.72

CAS:	63653-19-0

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (105)   
   UniProt (95)   
   SWISS-PROT (5)   
   RefSeq(pep) (5)   
DNA sequence (25)   
   RefSeq(nuc) (8)   
   GenBank (7)   
   EMBL (10)   
Protein domain (9)   
   InterPro (9)   
All databases (144)   

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