Entry |
|
Name |
methylisocitrate lyase;
2-methylisocitrate lyase;
MICL;
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase
|
Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
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Sysname |
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)
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Reaction(IUBMB) |
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = succinate + pyruvate [RN: R00409]
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Reaction(KEGG) |
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Substrate |
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate [CPD: C04593]
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Product |
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Comment |
The enzyme acts on threo-Ds-2-methylisocitrate, but not on threo-Ds-isocitrate, threo-DL-isocitrate or erythro-Ls-isocitrate.
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History |
EC 4.1.3.30 created 1978
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Pathway |
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Orthology |
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Genes |
TMF: | EYB26_002639 EYB26_006861 |
PTM: | GSPATT00025025001 GSPATT00036256001 |
ECOC: | C3026_01625(prpB) C3026_24795(prpB) |
ECOO: | ECRM13514_0519(prpB) |
ECOH: | ECRM13516_0309(prpB) |
ELR: | ECO55CA74_02115(prpB) |
ECW: | EcE24377A_0356(prpB) |
ECOA: | APECO78_05180(prpB) |
EDJ: | ECDH1ME8569_0319(prpB) |
ECOI: | ECOPMV1_00338(prpB) |
SEM: | STMDT12_C04300(prpB) |
SETC: | CFSAN001921_15205(prpB) |
SEEN: | SE451236_07850(prpB) |
SENH: | CFSAN002069_07010(prpB) |
SEEH: | SEEH1578_11260(prpB) |
SENJ: | CFSAN001992_09355(prpB) |
SEEC: | CFSAN002050_08430(prpB) |
SEEB: | SEEB0189_017470(prpB) |
SENC: | SEET0819_08795(prpB) |
PSHI: | SAMEA2665130_1484(prpB) |
SMW: | SMWW4_v1c14440(prpB) |
SERS: | SERRSCBI_06855(prpB) |
SFJ: | SAMEA4384070_1513(prpB) |
PHEI: | NCTC12003_01324(prpB) |
PRJ: | NCTC6933_02688(prpB) |
XFU: | XFF4834R_chr11310(prpB) |
XPH: | XppCFBP6546_05900(prpB) |
XHD: | LMG31886_32110(prpB) |
STEK: | AXG53_04145(prpB) AXG53_18815(prpB) |
LLZ: | LYB30171_02036(prpB) |
VAU: | VANGNB10_cI1218(prpB) |
VPL: | SA104470976_01084(prpB) |
PAEB: | NCGM1900_1980(prpB) |
PCQ: | PcP3B5_51720(prpB_2) |
PSYR: | N018_09745(prpB) N018_17605(prpB) |
PVD: | CFBP1590__2135(prpB) |
PPRC: | PFLCHA0_c18920(prpB) |
PMUD: | NCTC8068_01564(prpB) |
PFW: | PF1751_v1c41400(prpB) |
PFF: | PFLUOLIPICF715475(prpB) |
PPUU: | PputUW4_03658(prpB) |
PCAM: | HNE05_07530(prpB) HNE05_09110(prpB) |
PTRT: | HU722_0021840(prpB) |
PTW: | TUM18999_19690(prpB) |
PTAE: | NCTC10697_01186(prpB) |
MSHE: | MAALD49_18060(prpB) |
PSYC: | DABAL43B_1463(prpB) |
ABOU: | ACBO_10300(prpB_1) ACBO_14650(prpB_2) |
MCUN: | NCTC10297_00854(prpB) |
SCAA: | TUM17387_03140(prpB) |
PLZ: | S4054249_24625(prpB) |
PSEN: | PNC201_21055(prpB2) |
SALH: | HMF8227_00161(prpB) |
CBS: | COXBURSA331_A1177(prpB) |
LLG: | 44548918_01499(prpB) |
LJR: | NCTC11533_01461(prpB) |
LCJ: | NCTC11976_02195(prpB) |
LWA: | SAMEA4504053_1763(prpB_2) |
LSS: | NCTC12082_00606(prpB) |
LADL: | NCTC12735_00657(prpB) |
LANT: | TUM19329_19010(prpB) |
TLR: | Thiosp_00682(prpB) Thiosp_01967(dml) |
TFRI: | Thiofri_04767(prpB) |
TNI: | TVNIR_3340(prpB_[H]) |
HAXI: | HAALTHF_45300n HAALTHF_45310n |
ALCA: | ASALC70_00053(prpB_1) |
AEL: | NCTC12917_02495(prpB) |
NMM: | NMBM01240149_1659(prpB) |
NMS: | NMBM01240355_0438(prpB) |
NMQ: | NMBM04240196_0437(prpB) |
NMZ: | NMBNZ0533_1820(prpB) |
NMX: | NMA510612_2317(prpB) |
NWE: | SAMEA3174300_1282(prpB_1) |
NZO: | SAMEA4504057_2055(prpB_2) |
NCI: | NCTC10296_00752(prpB_2) |
RSO: | RSc2000(prpB1) RSp0122(prpB2) |
RPU: | CDC45_10230 CDC45_18195 |
RNC: | GO999_06865(prpB) GO999_22720(prpB) |
RSL: | RPSI07_1429(prpB) RPSI07_mp0087(prpB) |
RSN: | RSPO_c01437(prpB) RSPO_m00105(prpB2) |
RSM: | CMR15_11374(prpB) CMR15_mp10091(prpB) |
RSY: | RSUY_23080 RSUY_32940 |
RSG: | JK151_21260(prpB) JK151_22975(prpB) |
RPF: | Rpic12D_1831 Rpic12D_3975 |
RMN: | TK49_13640(prpB) TK49_19655(prpB) |
RWE: | KOL96_04025(prpB) KOL96_17050(prpB) |
BMN: | BMA10247_A2143(prpB) |
BPM: | BURPS1710b_A1735(prpB) |
BPL: | BURPS1106A_A0288(prpB) |
BPD: | BURPS668_A0382(prpB) |
BPZ: | BP1026B_II0229(prpB) |
BCAI: | K788_0000947 K788_0005066 |
PHS: | C2L64_31970 C2L64_36170 |
PTER: | C2L65_28705 C2L65_31380 C2L65_44720 |
PSAA: | QEN71_17555(prpB) QEN71_31065(prpB) |
PLG: | NCTC10937_02038(prpB) |
TVL: | FAZ95_15290(prpB) FAZ95_32525(prpB) FAZ95_37775(prpB) |
TCAR: | U0034_20310(prpB) U0034_26845(prpB) |
BHZ: | ACR54_02438(prpB_1) ACR54_03241(prpB_2) |
BTRM: | SAMEA390648702421(prpB_1) SAMEA390648702640(prpB_2) |
AXX: | ERS451415_01525(prpB) |
AAEG: | RA224_04025(prpB) RA224_24705(prpB) |
PUD: | G9Q38_01240(prpB) G9Q38_13010(prpB) |
BOZ: | DBV39_09145 DBV39_15125 |
PACR: | FXN63_10020(prpB) FXN63_13530(prpB) |
MUM: | FCL38_05855(prpB) FCL38_28410(prpB) |
URU: | DSM104443_01835(prpB) |
UPL: | DSM104440_01702(prpB) |
ALEG: | CFBP4996_17835(prpB) |
BARH: | WN72_33555(prpB) WN72_40190(prpB) |
BSEP: | HAP48_0038505(prpB) |
TSO: | IZ6_19820(prpB_1) IZ6_29220(prpB_2) |
PDIM: | PAF18_10525(prpB) PAF18_15720(prpB) |
LCK: | HN018_00005(prpB) HN018_03400 |
SVC: | STVA_15300(prpB_1) STVA_15390(prpB_2) |
HSH: | NHP194022_12910(prpB) |
CAMZ: | CVIC12175_1096(prpB) |
BAZ: | BAMTA208_12365(prpB) |
OON: | NP440_02505(prpB) NP440_16365(prpB) |
RUE: | DT065_17330(prpB) DT065_17420 |
SALE: | EPH95_17080(prpB) EPH95_17150 |
SCIB: | HUG20_05450(prpB) HUG20_05510 |
SCIA: | HUG15_07720(prpB) HUG15_07840 |
LASA: | L9O85_02775 L9O85_14975 |
MBAI: | MB901379_01274(prpB_2) |
MHEK: | JMUB5695_01383(mmgF) |
MPHL: | MPHLCCUG_00551(prpB) |
MSAR: | MSAR_02850(prpB_1) MSAR_05280(prpB_2) |
MSAL: | DSM43276_04449(prpB_2) |
MTER: | 4434518_01065(prpB) |
CGL: | Cgl0658(Cgl0658) Cgl0695(Cgl0695) |
CGB: | cg0760(prpB2) cg0797(prpB1) |
CGU: | WA5_0629(PrpB2) WA5_0665(PrpB1) |
CGS: | C624_00730 C624_04085 C624_04295 |
CGG: | C629_00730 C629_04085 C629_04295 |
CGM: | cgp_0760(prpB2) cgp_0797(prpB1) |
CGQ: | CGLAR1_03740 CGLAR1_03925 |
CGX: | SB89_03490 SB89_03670 |
CMIN: | NCTC10288_02001(prpB) |
CCYS: | SAMEA4530656_1890(prpB) |
BFV: | C628_03735 C628_03920 |
NFR: | ERS450000_04899(prpB) |
NNO: | NONO_c35970(prpB1) NONO_c62600(prpB2) |
NAD: | NCTC11293_05412(prpB) |
NWL: | NWFMUON74_21020(prpB) |
NSPU: | IFM12276_14540(prpB) |
TPUL: | TPB0596_00930(prpB) |
TOY: | FO059_05715(prpB) FO059_17180(prpB) |
YIA: | LO772_07110(prpB) LO772_33910(prpB) |
MSUW: | GCM10025863_29250(prpB) |
MINV: | T9R20_02755(prpB) T9R20_03840 |
FSB: | GCM10025867_35370(prpB) |
AMAU: | DSM26151_07960(mmgF) |
AMAV: | GCM10025877_17860 GCM10025877_29110(prpB) |
ALAV: | MTO99_12840(prpB) MTO99_15680(prpB) |
MALK: | MalAC0309_0760(prpB) |
PSEV: | USB125703_00467(prpB) |
LYH: | FrondiHNR_10745(prpB) |
ARQ: | BWQ92_00085 BWQ92_02390 |
AAGI: | NCTC2676_1_01043(prpB) |
AAU: | AAur_1661(prpB) AAur_pTC20151(prpB) |
PSNI: | NIBR502771_18055(prpB) |
GCR: | GcLGCM259_0955(prpB) |
MICK: | B1A86_00007060(prpB) |
GYU: | FE374_01925(prpB) FE374_16610(prpB) |
PSEE: | FRP1_00555 FRP1_14360 |
PSEH: | XF36_03215 XF36_03245 |
PSEQ: | AD006_08195 AD006_22025 |
PECQ: | AD017_01610 AD017_16025 |
PAUT: | Pdca_61640(prpB) Pdca_61790 |
LCRE: | Pla8534_12470(prpB) |
SMIZ: | 4412673_02505(prpB) |
SDJ: | NCTC13534_01530(prpB) |
STHA: | NCTC11429_04836(prpB) |
CHRJ: | CHRYMOREF3P_4844(prpB) |
NNEO: | PQG83_04735(prpB) PQG83_05145 |
TVO: | TVG0361650(TVG0361650) |
SCAS: | SACC_22480 SACC_24480 |
» show all
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Reference |
1 |
Authors |
Tabuchi, T. and Satoh, T. |
Title |
Distinction between isocitrate lyase and methylisocitrate lyase in Candida lipolytica. |
Journal |
Agric Biol Chem 40:1863-1869 (1976) |
Reference |
2 |
Authors |
Tabuchi, T. and Satoh, T. |
Title |
Purification and properties of methylisocitrate lyase, a key enzyme in propionate metabolism, from Candida lipolytica. |
Journal |
Agric Biol Chem 41:169-174 (1977) |
Other DBs |
ExplorEnz - The Enzyme Database: | 4.1.3.30 |
ExPASy - ENZYME nomenclature database: | 4.1.3.30 |
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