KEGG ENZYME: 4.1.3.32

ENZYME: 4.1.3.32

Entry

EC 4.1.3.32                 Enzyme

Name

2,3-dimethylmalate lyase;
2,3-dimethylmalate pyruvate-lyase;
(2R,3S)-2,3-dimethylmalate pyruvate-lyase

Class

Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases

Sysname

(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)

Reaction(IUBMB)

(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate [RN:R01355]

Reaction(KEGG)

R01355

Substrate

(2R,3S)-2,3-dimethylmalate [CPD:C03652]

Product

propanoate [CPD:C00163];
pyruvate [CPD:C00022]

History

EC 4.1.3.32 created 1981

Pathway

ec00760

Nicotinate and nicotinamide metabolism

ec01120

Microbial metabolism in diverse environments

Orthology

K20454

2,3-dimethylmalate lyase

Genes

GQU:	AWC35_01530

SLIG:

GTU79_03990

FHA:	CDV26_05960

TFRI:

Thiofri_03440(dml)

HCO:	LOKO_02505

HCAM:

I4484_05190

PEW:	KZJ38_30925

PTRP:

DCO17_04390

PWU:	A8O14_06540

BPAR:

BN117_0676(bcpA)

BBH:	BN112_2717(bcpA)

BBR:	BB0718(bcpA)

BBX:	BBS798_0696(bcpA)

PUS:	CKA81_07690

ODI:

ODI_R0009

BOZ:	DBV39_03915

ODH:	DHf2319_00265 DHf2319_11155 DHf2319_11260

PARK:

LSG25_18010 LSG25_18815

ACK:	C380_20060

LIH:	L63ED372_02665(dml_2)

UPL:	DSM104440_01949(dml)

ORM:	HTY61_08845

KMN:	HW532_10930

PECT:

BN1012_Phect2153

ARUI:

G6M88_20685

AVQ:	HRR99_16285

NEO:	CYG48_16600

BBT:

BBta_1130

BVES:

QO058_03755

RID:	RIdsm_00986(dml_3)

PARU:

CYR75_10275

PSHQ:

F3W81_11580

PARJ:

J4G78_07830

RFL:

Rmf_20650

RAP:	RHOA_3844(Dml)

SHUM:

STHU_07460(bcpA_1) STHU_28130(bcpA_2)

SVC:	STVA_12400(bcpA_1) STVA_27150(bcpA_2)

STEL:

STAQ_38210(bcpA_2)

ABS:	AZOBR_p330056

ABQ:	ABAZ39_28815

AZT:	TSH58p_31825

AARE:

D3093_31300

SMUC:

JL100_032930

DFL:

DFE_2439

DTO:	TOL2_C32170(prpB)

DMM:	dnm_064600

MRM:	A7982_01346

NANN:

O0S08_05205

NCM:	QNK12_15515

EFF:	skT53_09420(bcpA)

CAH:	CAETHG_2513

ACOL:

K5I23_11355

LASA:

L9O85_02780 L9O85_04450

PETR:

QKW49_10675

DOR:	Desor_0458

DGI:	Desgi_2645

ACAE:

HYG86_14530

SAY:	TPY_1957(prpB)

SAP:	Sulac_2154

PROM:

QO263_18020

CASP:

NQ535_09980

GEK:	kuro4_04500(bcpA)

TEP:	TepRe1_0405

TAE:	TepiRe1_0449(Dml)

BACG:

D2962_02755 D2962_17090

NTH:	Nther_2154

STED:

SPTER_39090(dml)

PFAC:

PFJ30894_01316(Dml)

FCZ:	IMF26_03545

MTY:	MTOK_12610(prpB)

RAV:	AAT18_21745

RKO:	JWS14_17170

RANT:

RHODO2019_14065

DIZ:	CT688_06965

SBAT:

G4Z16_05070 G4Z16_31580

SSPN:

LXH13_01160

NFC:	KG111_04820 KG111_05725

AEZ:	C3E78_17385

AEF:	GEV26_17140

MUZ:	H4N58_12845

BSD:	BLASA_3403

MMAR:

MODMU_4056

AMQ:	AMETH_3328

AACD:

LWP59_10150 LWP59_17900

ATHM:

L1857_19500

ARHD:

VSH64_05085

PDX:

Psed_4635

PSEA:

WY02_01050

PSEE:

FRP1_09770

PSEQ:

AD006_17330

PECQ:

AD017_25165

PAUT:

Pdca_36590(bcpA)

PBRO:

HOP40_34515

PPEL:

H6H00_31555

ACTY:

OG774_01265

AIH:	Aiant_14510(prpB)

ASIC:

Q0Z83_062830

RMAR:

GBA65_08220

BSOL:

FSW04_13030

SBAE:

DSM104329_05580(dml_2)

KBS:	EPA93_17300

TNR:	Thena_1095

SDYN:

Mal52_03470(dml)

PLON:

Pla110_27420(dml)

PVAR:

SH412_004720

ACO:	Amico_1318

TLI:

Tlie_1837

AMO:	Anamo_1755

PPIO:

CE91St28_16560

PYY:	RAH42_03105

SRUB:

C2R22_03360

SCAS:

SACC_14220

SULA:

BFU36_12520

SULE:

GFS03_03475

SULO:

GFS33_07745

SULL:

EWF20_07395

MEMJ:

MJ1HA_1418

MHK:	DFR87_12740

MPRU:

DFR88_00255

MJN:	MjAS7_2235

» show all

Reference

1 [PMID:527937]

Authors

Pirzer P, Lill U, Eggerer H.

Title

Nicotinic acid metabolism. 2,3-Dimethylmalate lyase.

Journal

Hoppe Seylers Z Physiol Chem 360:1693-702 (1979)
DOI:10.1515/bchm2.1979.360.2.1693

Sequence

[ag:ABC88406]

Reference

2 [PMID:16894175]

Authors

Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.

Title

Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.

Journal

Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103

Sequence

[ag:ABC88406]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.3.32

IUBMB Enzyme Nomenclature:

4.1.3.32

ExPASy - ENZYME nomenclature database:

4.1.3.32

BRENDA, the Enzyme Database:

4.1.3.32

CAS:	73562-28-4

DBGET integrated database retrieval system