Entry
Name
3-hydroxypropionyl-CoA dehydratase;
3-hydroxypropionyl-CoA hydro-lyase;
3-hydroxypropanoyl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-hydroxypropanoyl-CoA hydro-lyase
Reaction(IUBMB)
3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O [RN:
R03045 ]
Reaction(KEGG)
Substrate
3-hydroxypropanoyl-CoA [CPD:
C05668 ]
Product
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA [2].
History
EC 4.2.1.116 created 2009
Pathway
ec00720 Carbon fixation pathways in prokaryotes
ec01120 Microbial metabolism in diverse environments
Orthology
K14469 acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15019 3-hydroxypropionyl-coenzyme A dehydratase
Genes
PAQM : E0F26_06440 E0F26_07705
BQB : J4P68_0034680 J4P68_0034780
DMP : FAK_14930 FAK_16740(yngF)
DOM : RRU94_07805 RRU94_25040
MHOL : K3U96_16025 K3U96_21285
AACD : LWP59_05945 LWP59_12750
BALA : DSM104299_01578(echA8_2) DSM104299_01953 DSM104299_04760(echA8_5)
PARN : NBH00_05565 NBH00_06975
TALU : JDY09_03435 JDY09_08375
LUB : TBR22_A09330 TBR22_A49180
NARA : QQ977_05470 QQ977_05545
SSHI : J5U23_00433 J5U23_02754
SULO : GFS33_00250 GFS33_04315
TAA : NMY3_00896(echA8_1) NMY3_01290(echA8_2)
NDV : NDEV_0058(crt) NDEV_1640(hpcD)
LOB : NEF87_000100 NEF87_002373 NEF87_003343
» show all
Taxonomy
Reference
Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
Journal
Sequence
Reference
Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.116