KEGG   ENZYME: 4.2.1.124
Entry
EC 4.2.1.124                Enzyme                                 
Name
arabidiol synthase;
PEN1 (gene name);
(S)-squalene-2,3-epoxide hydro-lyase (arabidiol forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (arabidiol-forming)
Reaction(IUBMB)
arabidiol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O [RN:R09700]
Reaction(KEGG)
R09700
Substrate
arabidiol [CPD:C19828]
Product
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054];
H2O [CPD:C00001]
Comment
The reaction occurs in the reverse direction.
History
EC 4.2.1.124 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15823  arabidiol synthase
Genes
ATHAT4G15340(PEN1)
Reference
1  [PMID:16774269]
  Authors
Xiang T, Shibuya M, Katsube Y, Tsutsumi T, Otsuka M, Zhang H, Masuda K, Ebizuka Y
  Title
A new triterpene synthase from Arabidopsis thaliana produces a tricyclic triterpene with two hydroxyl groups.
  Journal
Org Lett 8:2835-8 (2006)
DOI:10.1021/ol060973p
  Sequence
[ath:AT4G15340]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.124
IUBMB Enzyme Nomenclature: 4.2.1.124
ExPASy - ENZYME nomenclature database: 4.2.1.124
BRENDA, the Enzyme Database: 4.2.1.124

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