KEGG ENZYME: 4.2.1.43

ENZYME: 4.2.1.43

Entry

EC 4.2.1.43                 Enzyme

Name

2-dehydro-3-deoxy-L-arabinonate dehydratase;
2-keto-3-deoxy-L-arabinonate dehydratase;
2-dehydro-3-deoxy-L-arabinonate hydro-lyase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)

Reaction(IUBMB)

2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O [RN:R02278]

Reaction(KEGG)

R02278

Substrate

2-dehydro-3-deoxy-L-arabinonate [CPD:C00684]

Product

2,5-dioxopentanoate [CPD:C00433];
H2O [CPD:C00001]

History

EC 4.2.1.43 created 1972

Pathway

ec00053

Ascorbate and aldarate metabolism

ec01100

Metabolic pathways

Orthology

K13876

2-keto-3-deoxy-L-arabinonate dehydratase

Genes

CTU:

CTU_06570

KMI:	VW41_03260

CAF:	AL524_22380

EBT:	EBL_c33280

KCO:	BWI95_18060

BUF:	D8682_18995

BAGE:

BADSM9389_06400

BFT:	MNO13_03305

SUPE:

P0H77_05650

EBB:

F652_2947

SPE:

Spro_0707

SLQ:	M495_02890

SQU:	E4343_13080

ROX:	BV494_01165

RVC:	J9880_24230

SOD:

Sant_0675

EPE:	CI789_02275

HAV:	AT03_19840

HPAR:

AL518_06710

OPO:	DSM2777_05585

LPV:	HYN51_09415

PRAG:

EKN56_20130

RFO:	REIFOR_01233

LLP:	GH975_02685

RPI:

Rpic_3006

RPF:	Rpic12D_2596

RPJ:	N234_21925

RMN:	TK49_06590

RWE:	KOL96_20620

REH:	H16_B0213(dapA2)

CNC:	CNE_2c01980(dapA1)

CUH:	BJN34_21090

CTI:	RALTA_B0220

CBW:	RR42_s0473

CGD:	CR3_3974(araD)

CCUP:

BKK81_02470

CPAU:

EHF44_25915

COX:	E0W60_07020

CCAX:

KZ686_23220

CUK:	KB879_18770

CNAN:

A2G96_21660

BTE:	BTH_II1630

BTQ:	BTQ_4919(araD)

BTJ:	BTJ_3543(araD)

BTZ:	BTL_4392(araD)

BTD:	BTI_5591(araD)

BTV:	BTHA_3565(araD)

BTHE:

BTN_4043(araD)

BTHM:

BTRA_4050(araD)

BTHA:

DR62_4079

BTHL:

BG87_4375(AraD)

BHG:	I6G56_24130

BUD:	AQ610_26805

BVI:	Bcep1808_3834

BVE:	AK36_4877(araD)

BUR:	Bcep18194_B0042 Bcep18194_B3057

BCM:	Bcenmc03_4375 Bcenmc03_4586 Bcenmc03_6235

BCH:	Bcen2424_5643 Bcen2424_5804 Bcen2424_6637

BCJ:	BCAM0104 BCAM2800

BCEN:

DM39_5046(araD) DM39_6177(araD)

BCEW:

DM40_3367(araD)

BCEO:

I35_6679

BAM:	Bamb_3398 Bamb_4923

BAC:	BamMC406_3210 BamMC406_5478

BMJ:	BMULJ_05321(dapA)

BMU:

Bmul_3204

BMK:	DM80_4584(araD)

BMUL:

NP80_3349(araD)

BCT:	GEM_3979 GEM_5481 GEM_5607

BCED:

DM42_5188(araD)

BCEP:

APZ15_24595

BDL:	AK34_5007(araD)

BPYR:

ABD05_20735 ABD05_21635 ABD05_31625

BCON:

NL30_17845 NL30_24965

BUB:	BW23_3987(araD) BW23_4351(araD)

BDF:	WI26_15735 WI26_26560

BLAT:

WK25_29415

BTEI:

WS51_10640

BSEM:

WJ12_16065 WJ12_33860

BPSL:

WS57_00265 WS57_05740

BMEC:

WJ16_20380 WJ16_32370

BSTG:

WT74_22175 WT74_32755

BSTL:

BBJ41_21670

BANN:

JFN94_18020 JFN94_18890 JFN94_26305

BARI:

NLX30_22220 NLX30_23130

BAEN:

L3V59_22125

BGL:	bglu_1g17850

BGU:	KS03_2640(araD)

BUG:	BC1001_4105

BGF:	BC1003_5311

BGD:	bgla_2g13470

BGO:	BM43_5015(araD)

BYI:	BYI23_B013290 BYI23_D004040 BYI23_D009640

BUK:

MYA_3489

BUE:	BRPE67_BCDS00220 BRPE67_DCDS05750 BRPE67_DCDS11690

BUL:	BW21_5279(araD)

BUQ:	AC233_29080

BGP:	BGL_1c19710

BPLA:

bpln_1g18020

BUM:	AXG89_11870 AXG89_22230

BUI:	AX768_05665 AX768_24750

BURK:

DM992_25760 DM992_26925 DM992_37145

BPH:

Bphy_6711

BGE:	BC1002_4374

BPX:	BUPH_00687

BPY:	Bphyt_4575

BFN:	OI25_5423 OI25_6642

BCAI:

K788_0005071 K788_0008592

PSPW:

BJG93_24260

PARA:

BTO02_21210

PARB:

CJU94_24595 CJU94_26045

PHS:	C2L64_22580 C2L64_36150 C2L64_52290

PTER:

C2L65_25020 C2L65_31360

PGP:	CUJ91_27135

PCJ:	CUJ87_17870

PTS:	CUJ90_19400

PCAF:

DSC91_000932 DSC91_002982

PMEG:

FNZ07_06590

PTRO:

G5S35_23715 G5S35_32515 G5S35_33960

PGIS:

I6I06_18090 I6I06_25055

PACP:

FAZ97_24140 FAZ97_34310

PACS:

FAZ98_28815

PEW:	KZJ38_22555

PBRY:

NDK50_12435 NDK50_25490

PSAA:

QEN71_12585 QEN71_31040

PKF:	RW095_10970

PBON:

QS306_09900

PPAI:

E1956_35875

CABA:

SBC2_14340(dapA_3) SBC2_66650(araD)

BUO:	BRPE64_BCDS00230 BRPE64_CCDS05510 BRPE64_DCDS07830

CABK:

NK8_42780 NK8_45750 NK8_66410

TVL:	FAZ95_24110

TCAR:

U0034_21535

BHO:

D560_1639

BHM:

D558_1627

BBRO:

BAU06_17390

BFZ:	BAU07_05105

BPDZ:

BBN53_13505

AXY:	AXYL_04351

AXO:	NH44784_063331

AXN:	AX27061_4574

AXX:	ERS451415_04605(yagE_2)

ADT:	APT56_21015

AIS:	BUW96_10930

ASW:	CVS48_23105

ACHR:

C2U31_09970 C2U31_16375

ACHB:

DVB37_17495

ADY:	HLG70_02415

APES:

FOC84_24125

AAEG:

RA224_11345

POLL:

OEG81_15295

CDN:	BN940_14416

ODI:

ODI_R4258

PARK:

LSG25_17845

RFR:

Rfer_0453

RSB:	RS694_18415

RHY:	RD110_12005

RHOB:

HTY51_17305

POL:

Bpro_2837

PVAC:

HC248_02301(araD)

ACK:	C380_10450

ACIO:

EAG14_03785

ARAD:

KI609_13600

AAV:

Aave_2247

AAA:	Acav_2893 Acav_4648

AMON:

H9L24_15665

VEI:	Veis_2707 Veis_3541

DAC:

Daci_4983

DEL:	DelCs14_1862

DTS:	BI380_30715

DHK:	BO996_22910

DLA:	I6G47_31125

VAP:	Vapar_1052

VPE:	Varpa_1121

VPD:	VAPA_1c11050 VAPA_2c00550(dapA)

VAA:	AX767_04455

VBO:	CKY39_05220

VAM:	C4F17_13930

CTT:	CtCNB1_3908

CTES:

O987_23535

AANT:

HUK68_00055

HPSE:

HPF_09020(araD)

HGR:	DW355_08820

RDP:	RD2015_2629

ROI:	N4261_12725

ATER:

MW290_14215 MW290_26310

HSE:	Hsero_1368(dapA)

HSZ:	ACP92_06865

HHT:	F506_04770

HRB:	Hrubri_1189(dapA)

HEE:	hmeg3_00985

HHF:	E2K99_06845

HFR:	G5S34_07085

GLC:	JQN73_14925

XYK:	GT347_21915

URU:	DSM104443_00662(araD_1)

MES:

Meso_3971

AAK:	AA2016_4939

AMIH:

CO731_04159(yagE_2)

RPOD:

E0E05_09145

ORM:	HTY61_17225

SMX:	SM11_pC1295

SMER:

DU99_23820

SIX:	BSY16_5632

EAD:	OV14_a1105(dapA)

RHR:	CKA34_25505

SHZ:

shn_14790

BJA:	bll7953(bll7953)

BJU:	BJ6T_12720

BJP:	RN69_06220

BRA:

BRADO1813

BBT:

BBta_2133

BRS:

S23_65840

AOL:

S58_57230

BRC:	BCCGELA001_04085 BCCGELA001_29135

BRAD:

BF49_3436

BIC:	LMTR13_30020

BRO:	BRAD285_5472(araD)

BRK:	CWS35_02785

BOT:	CIT37_03940 CIT37_08040

BRQ:	CIT40_29215

BGQ:	X265_04835

BGZ:	XH91_05125

BSYM:

CIT39_28240

BBET:

F8237_12250

BARH:

WN72_04140 WN72_09275

BVZ:	BRAD3257_8478(araD)

BEL:	BE61_14750(dapA)

BDG:	LPJ38_08405 LPJ38_36410

BSEP:

HAP48_0019235

BQB:	J4P68_0022725

BBAN:

J4G43_004605

BCAN:

BcanWSM471_34955

BAUT:

QA635_38820

BBRA:

QA636_40230

BGK:	IC762_07845

BCOU:

IC761_04360

BPAH:

QA639_39190

BXN:	I3J27_36690

BROS:

QUH67_27315

BRAZ:

LRP30_02625

BOP:	AXW83_15040

BOS:	BSY19_2309 BSY19_4559

BVV:	BHK69_13550 BHK69_23230

BOI:	BLM15_13485 BLM15_28230

BOF:	FQV39_01140 FQV39_05845 FQV39_14530

BVES:

QO058_07785 QO058_24285

BAPA:

BBC0178_012570

XAU:

Xaut_1021

STAR:

G3545_22980

SNO:

Snov_0118

APRA:

G3A50_11630

APOL:

K9D25_15455

MRD:	Mrad2831_4925

MOR:

MOC_5613

MAQU:

Maq22A_c05765(dapA)

MPHY:

MCBMB27_04363

MEE:	DA075_26795

METX:

A3862_07295

MMES:

MMSR116_28745

MTEA:

DK419_06420

MIND:

mvi_28100

MTAD:

M6G65_22580

MOC:	BB934_07055

MIV:	C4E04_02010

MTEZ:

HPT29_020335

MLD:	U0023_03140

BID:

Bind_3080

CHEL:

AL346_04990

DEA:	FPZ08_12195

MMYR:

MXMO3_02356

HDI:	HDIA_0216(araD)

AALA:

IGS74_14615

AALM:

LUX29_16530

AUZ:	Sa4125_16180

JIE:	OH818_12675

NOH:	G5V57_05530

LAP:	ACP90_11030

LABT:

FIU93_14080(araD1) FIU93_16605(araD2)

LAGG:

B0E33_22965

PHR:	C6569_02935

PSTG:

E8M01_07905

PAQT:

E8L99_18140

LIZ:	LGH83_06415

ACUT:

MRB58_07415

SIL:

SPOA0244

DSH:

Dshi_2446

OAR:	OA238_c12510

MALG:

MALG_03895 MALG_04381 MALG_04456

YPAC:

CEW88_03665

YAN:	AYJ57_10815

SULZ:

C1J03_13130

SULD:

B5M07_05330

SINL:

DSM14862_02690(araD)

RID:	RIdsm_01841(araD)

AHT:	ANTHELSMS3_03458

SAGU:

CDO87_19365

THAA:

CFI11_20005

OCD:	FHY55_19120

MALU:

KU6B_19310

PALX:

GQA70_14560

TRY:	QF118_16770

PDE:

Pden_4666

PAMI:

JCM7686_3316

PYE:	A6J80_10095

PCON:

B0A89_02490

PZH:	CX676_00745

PARO:

CUV01_13830

PMUT:

DPM13_08295

PSAN:

HGN31_05465

PALS:

PAF20_17050

PTP:	RCA23_c06720 RCA23_c06790(dapA3) RCA23_c23430

RHC:

RGUI_3959

RMB:	K529_014365 K529_016090

RBZ:	B9057_15760

LVS:	LOKVESSMR4R_03077(araD)

SALO:

EF888_19155

LIT:	FPZ52_15850

PALW:

PSAL_020910(araD)

PSHQ:

F3W81_19105

PPAF:

I8N54_02195

FAP:	GR316_11125

PBAE:

P8S53_17450

NOV:	TQ38_023065

SPHI:

TS85_03755

ACR:

Acry_2738

AMV:	ACMV_30670

RGI:	RGI145_17600

ROS:	CTJ15_16450

RMUC:

FOB66_22025

RMT:	IAI58_08570

RCV:	PFY06_19765

RAP:

RHOA_2195

ACIM:

GT370_05260

AZL:	AZL_e03630(dapA)

ALI:	AZOLI_p50377(araD)

ABS:	AZOBR_p440160

ABQ:	ABAZ39_31595

ABF:	AMK58_27385

ATI:	AL072_31000

AHU:	A6A40_14230

AZT:	TSH58p_21360

AZM:	DM194_26435

AZZ:	DEW08_22000

AOZ:	HUE56_23205 HUE56_26165

AARE:

D3093_27765 D3093_30990

AZS:	E6C72_28390

SKT:	IGS68_08980 IGS68_30525

SMUC:

JL100_018400 JL100_031430

SROE:

JL101_017100 JL101_031855

HTQ:	FRZ44_40650

NACI:

NUH88_17205

THAR:

T8K17_07875

PAUN:

MJA45_14130

NTR:	B0W44_15610

SRN:	A4G23_03540(dapA_3)

MOY:	CVS54_01202(araD)

HEA:	HL652_17435 HL652_17800

PDEL:

JCQ34_14735

SATK:

SA2016_0951

BCV:

Bcav_3940

MICG:

GJV80_08325

NOA:	BKM31_21025

NAK:	EH165_10140

AAB:	A4R43_04445

AMYY:

YIM_17550(araD)

AACD:

LWP59_14525

PAUT:

Pdca_64040

ACTI:

UA75_20040

ACAD:

UA74_19550

PMAD:

BAY61_16470

PVS:	A1sIA79_05270

NHI:	B1s21160_02175

MTAR:

DF168_00716(araD_1) DF168_00971(araD_2)

RUL:	UC8_01250(araD)

ROL:	CA51_31580(dapA_3)

RUV:	EC9_20450(dapA_1)

LCRE:

Pla8534_61970(araD)

AAGG:

ETAA8_26400(araD)

PBS:	Plabr_4261

PLS:	VT03_23390(dapA_3)

FMR:	Fuma_05619(araD)

GMR:	GmarT_22610(araD)

GIM:	F1728_03120

GPN:	Pan110_21890(araD)

GFM:	Enr17x_23730(araD)

SDYN:

Mal52_40300(araD_1) Mal52_45600(araD_2)

PLON:

Pla110_17110(araD_1) Pla110_46420(araD_2)

PFER:

IRI77_21920 IRI77_22525

ABAC:

LuPra_02639(araD_1)

FLA:	SY85_11775

FLC:	KJS93_18565

CMR:	Cycma_0043

SLI:

Slin_0609

SRD:	SD10_11625

SPIK:

EXU85_24685

SFOL:

H3H32_14580

DPF:	ON006_20665

RUN:	DR864_11930 DR864_18420

RUP:	DTQ70_25045

FAC:	FACI_IFERC01G0501

» show all

Reference

1 [PMID:5954356]

Authors

Stoolmiller AC, Abeles RH.

Title

Formation of alpha-ketoglutaric semialdehyde from L-2-keto-3-deoxyarabonic acid and isolation of L-2-keto-3-deoxyarabonate dehydratase from Pseudomonas saccharophila.

Journal

J Biol Chem 241:5764-71 (1966)

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.43

IUBMB Enzyme Nomenclature:

4.2.1.43

ExPASy - ENZYME nomenclature database:

4.2.1.43

BRENDA, the Enzyme Database:

4.2.1.43

CAS:	37263-10-8

DBGET integrated database retrieval system