KEGG   ENZYME: 4.2.2.21
Entry
EC 4.2.2.21                 Enzyme                                 
Name
chondroitin-sulfate-ABC exolyase;
chondroitinase (ambiguous);
chondroitin ABC eliminase (ambiguous);
chondroitinase ABC (ambiguous);
chondroitin ABC lyase (ambiguous);
chondroitin sulfate ABC lyase (ambiguous);
ChS ABC lyase (ambiguous);
chondroitin sulfate ABC exoeliminase;
chondroitin sulfate ABC exolyase;
ChS ABC lyase II
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
Sysname
chondroitin-sulfate-ABC exolyase
Reaction(IUBMB)
Exolytic removal of Delta4-unsaturated disaccharide residues from the non-reducing ends of both polymeric chondroitin/dermatan sulfates and their oligosaccharide fragments.
Reaction(KEGG)
(other) R10870 R10871 R10872
Comment
This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. The related enzyme EC 4.2.2.20, chondroitin-sulfate-ABC endolyase, has the same substrate specificity but produces a mixture of oligosaccharides of different sizes that are ultimately degraded to tetra- and disaccharides [4]. Both enzymes act by the removal of a relatively acidic C-5 proton of the uronic acid followed by the elimination of a 4-linked hexosamine, resulting in the formation of an unsaturated C4---C5 bond on the hexuronic acid moiety of the products [4,6].
History
EC 4.2.2.21 created 2006 (EC 4.2.2.4 created 1972, part-incorporated 2006 (EC 4.2.99.6 created 1965, part incorporated 1976)), modified 2010
Orthology
K08961  chondroitin-sulfate-ABC endolyase/exolyase
Genes
SESSARI_02380
YPEYPO0824
YPKy3211
YPHYPC_0996
YPAYPA_0445
YPNYPN_3027
YPMYP_2832
YPPYPDSF_0688
YPGYpAngola_A3277
YPZYPZ3_0887
YPTA1122_00920
YPDYPD4_0844
YPXYPD8_0842
YPWCH59_1039
YPJCH55_3716 CH55_3717
YPVBZ15_2750
YPLCH46_92
YPSYPTB3073
YPOBZ17_3545
YPIYpsIP31758_0946
YPYYPK_0997
YPBYPTS_3194
YPQDJ40_3406
YPUBZ21_2390
YPRBZ20_3090
YPCBZ23_2669
YPFBZ19_2453
YSIBF17_01850
YRUBD65_2433
YRBUGYR_12535
PMRPMI2127 PMI2128
PMIBBB2000_2202 BB2000_2203
PVLAOB99_12450 AOB99_12455
PVGCRN77_08480 CRN77_08485
PHAUPH4a_02555 PH4a_02560
PROTBTA34_12080 BTA34_12085
PCOLF1325_14000 F1325_14005
PCIBF9282_14105 F9282_14110
PPEEI6G31_14140 I6G31_14145
MWIMNY66_11575 MNY66_11580
EICNT01EI_3294 NT01EI_3295
ETRETAE_2917 ETAE_2918
ETDETAF_2650 ETAF_2651
ETEETEE_1143 ETEE_1144
ETCETAC_14050 ETAC_14055
EDWQY76_05730 QY76_05735
EDLAAZ33_15510 AAZ33_15515
EHOA9798_02620 A9798_02625
APAGEIA51_01230 EIA51_07155
AVTNCTC3438_00390 NCTC3438_01189
VAFD1115_15465 D1115_15565 D1115_15575
PPRPBPRB0153
PGBH744_2c1761 H744_2c1762 H744_2c1785 H744_2c1789
PDSCAY62_18680
PLZS4054249_13715
ENWMJO57_23830
VHLBME96_15890
LBWC3V36_09930
VGUHYG85_13675 HYG85_20055
VPYHZI73_07975
SBYH7H31_29120
STRZOYE22_28345
MCHNHCR76_14735
ARMART_3703
BRVCFK39_06120
BRZCFK38_04965 CFK38_06655
PRVG7070_09475
ACIROG979_28660
SROSros_2256
OLEK0B96_16470
PUORZN69_09950 RZN69_13390
AGLPYTT_0964
LAMBKBB96_08400
PBASSMSP2_01417(chonabc_1) SMSP2_01425(chonabc_2)
TAERGT409_06540 GT409_06585 GT409_07600 GT409_07615 GT409_07765 GT409_11920 GT409_11925
LPROPQO03_05560 PQO03_05725 PQO03_08425 PQO03_18540
FMOC4N19_04665
CSOMMKD34_01195
BTHBT_3324 BT_3350
BTHOBtheta7330_04950(chonabc_1) Btheta7330_04976(chonabc_2)
BHLBache_0583
BXYBXY_25910 BXY_26470
BOABovatus_03443(chonabc_1) Bovatus_03480(chonabc_2)
BCELBcellWH2_02521 BcellWH2_02528(chonabc)
BCACCGC64_04155 CGC64_04295
BCAEA4V03_18910 A4V03_19125
BZGC4H11_08555
BHFC3V43_09815
BISDXK01_003740 DXK01_003755
BUNBun01g_09420(chonabc)
BEGINE88_01708 INE88_01710(chonabc)
BSTEK6V31_10320 K6V31_11145
BFEK6V30_05210 K6V30_05360 K6V30_11685
BNOK8P02_06335 K8P02_06350 K8P02_19060 K8P02_19100 K8P02_19165
BHUMJXR92_004870
BFCBacF7301_06000 BacF7301_06155
BSALK6V25_04780 K6V25_04830
BFINBFINE_06830 BFINE_07270(chonabc)
COPRCop2CBH44_21620(chonabc_1) Cop2CBH44_21690 Cop2CBH44_25750 Cop2CBH44_27640(chonabc_2)
CFASCfast33896_15040 Cfast33896_15070 Cfast33896_15120
PDTPrede_1246
POCNCTC13071_00480
ASHAL1_08200 AL1_08220
COYHF329_09485
NSONIASO_15730
NIAA8C56_05425
ARKD6B99_04970
PHEPhep_0784 Phep_2838
PEPAQ505_08345
PEJFYC62_06795 FYC62_06820
PGJQG516_06555
PSNPedsa_0057 Pedsa_3805
ESTDN752_00855
RCGN7E81_09370 N7E81_17080
FCOFCOL_05500
FGLEM308_03130 EM308_03135 EM308_14410
FCMBIW12_00075 BIW12_15965 BIW12_15970
FCVAWN65_08505
FOEJJC03_10185
ZLAQ5W13_18245
PHALH9I45_07800
AHZAPS56_04620 APS56_04640
FOPFNB79_14950
HWSRNZ46_12845
ORHOrnrh_0305 Ornrh_0807
ORIQ785_01660 Q785_04595
CCAUEG346_19755 EG346_21420
 » show all
Reference
1  [PMID:5647268]
  Authors
Yamagata T, Saito H, Habuchi O, Suzuki S.
  Title
Purification and properties of bacterial chondroitinases and chondrosulfatases.
  Journal
J Biol Chem 243:1523-35 (1968)
Reference
2  [PMID:4231029]
  Authors
Saito H, Yamagata T, Suzuki S.
  Title
Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates.
  Journal
J Biol Chem 243:1536-42 (1968)
Reference
3  [PMID:5647269]
  Authors
Suzuki S, Saito H, Yamagata T, Anno K, Seno N, Kawai Y, Furuhashi T.
  Title
Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion.
  Journal
J Biol Chem 243:1543-50 (1968)
Reference
4  [PMID:9083041]
  Authors
Hamai A, Hashimoto N, Mochizuki H, Kato F, Makiguchi Y, Horie K, Suzuki S
  Title
Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides.
  Journal
J Biol Chem 272:9123-30 (1997)
DOI:10.1074/jbc.272.14.9123
Reference
5  [PMID:16336265]
  Authors
Huckerby TN, Nieduszynski IA, Giannopoulos M, Weeks SD, Sadler IH, Lauder RM.
  Title
Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides.
  Journal
FEBS J 272:6276-86 (2005)
DOI:10.1111/j.1742-4658.2005.05009.x
Reference
6  [PMID:18992215]
  Authors
Zhang Z, Park Y, Kemp MM, Zhao W, Im AR, Shaya D, Cygler M, Kim YS, Linhardt RJ
  Title
Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern.
  Journal
Anal Biochem 385:57-64 (2009)
DOI:10.1016/j.ab.2008.10.014
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.21
IUBMB Enzyme Nomenclature: 4.2.2.21
ExPASy - ENZYME nomenclature database: 4.2.2.21
BRENDA, the Enzyme Database: 4.2.2.21
CAS: 1000607-06-6

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