KEGG   ENZYME: 4.2.3.100
Entry
EC 4.2.3.100                Enzyme                                 
Name
bicyclogermacrene synthase;
Ov-TPS4
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate [RN:R09900]
Reaction(KEGG)
R09900
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
bicyclogermacrene [CPD:C20175];
diphosphate [CPD:C00013]
Comment
The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor. With Mg2+ a more complex mixture is produced.
History
EC 4.2.3.100 created 2012
Orthology
K21980  bicyclogermacrene synthase
Reference
1  [PMID:20419468]
  Authors
Crocoll C, Asbach J, Novak J, Gershenzon J, Degenhardt J
  Title
Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis.
  Journal
Plant Mol Biol 73:587-603 (2010)
DOI:10.1007/s11103-010-9636-1
  Sequence
[ag:ADK73618]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.100
IUBMB Enzyme Nomenclature: 4.2.3.100
ExPASy - ENZYME nomenclature database: 4.2.3.100
BRENDA, the Enzyme Database: 4.2.3.100

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (15)   
   UniProt (10)   
   SWISS-PROT (5)   
Protein domain (9)   
   InterPro (9)   
All databases (31)   

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