KEGG   ENZYME: 4.2.3.129
Entry
EC 4.2.3.129                Enzyme                                 
Name
(+)-sativene synthase;
cop4
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-sativene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate [RN:R10008]
Reaction(KEGG)
R10008
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-sativene [CPD:C20275];
diphosphate [CPD:C00013]
Comment
Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-copaene, beta-cubebene, and traces of several other sequiterpenoids. See EC 4.2.3.13, (+)-delta-cadinene synthase, EC 4.2.3.127, beta-copaene synthase, and EC 4.2.3.128, beta-cubebene synthase.
History
EC 4.2.3.129 created 2012
Orthology
K22058  cubebol/beta-copaene/beta-cubebene/(+)-sativene synthase
Genes
CCI: CC1G_06441
Reference
1  [PMID:19400802]
  Authors
Agger S, Lopez-Gallego F, Schmidt-Dannert C
  Title
Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus.
  Journal
Mol Microbiol 72:1181-95 (2009)
DOI:10.1111/j.1365-2958.2009.06717.x
  Sequence
[cci:CC1G_06441]
Reference
2  [PMID:20419721]
  Authors
Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C
  Title
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.
  Journal
Chembiochem 11:1093-106 (2010)
DOI:10.1002/cbic.200900671
  Sequence
[cci:CC1G_06441]
Reference
3  [PMID:20889795]
  Authors
Lopez-Gallego F, Wawrzyn GT, Schmidt-Dannert C
  Title
Selectivity of fungal sesquiterpene synthases: role of the active site's H-1 alpha loop in catalysis.
  Journal
Appl Environ Microbiol 76:7723-33 (2010)
DOI:10.1128/AEM.01811-10
  Sequence
[cci:CC1G_06441]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.129
IUBMB Enzyme Nomenclature: 4.2.3.129
ExPASy - ENZYME nomenclature database: 4.2.3.129
BRENDA, the Enzyme Database: 4.2.3.129

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (12)   

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