KEGG   ENZYME: 4.2.3.130
Entry
EC 4.2.3.130                Enzyme                                 
Name
tetraprenyl-beta-curcumene synthase;
ytpB (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
all-trans-heptaprenyl-diphosphate diphosphate-lyase (cyclizing, tetraprenyl-beta-curcumene-forming)
Reaction(IUBMB)
all-trans-heptaprenyl diphosphate = tetraprenyl-beta-curcumene + diphosphate [RN:R10009]
Reaction(KEGG)
R10009
Substrate
all-trans-heptaprenyl diphosphate [CPD:C04216]
Product
tetraprenyl-beta-curcumene [CPD:C20276];
diphosphate [CPD:C00013]
Comment
Isolated from Bacillus subtilis. This sesquarterpene is present in a number of Bacillus species.
History
EC 4.2.3.130 created 2012
Orthology
K16188  tetraprenyl-beta-curcumene synthase
Genes
SAT: SYN_01806
BSU: BSU30500(ytpB)
BSR: I33_3107
BSL: A7A1_2184
BSH: BSU6051_30500(ytpB)
BSY: I653_14615
BSUT: BSUB_03240
BSUL: BSUA_03240(ytpB)
BSUS: Q433_16545
BSO: BSNT_09473(ytpB)
BSN: BSn5_06095
BSQ: B657_30500
BSX: C663_2898
BSP: U712_15150
BSS: BSUW23_14790(ytpB)
BST: GYO_3302
BIT: BIS30_04630
BLI: BL00005(ytpB)
BLD: BLi03190(ytpB)
BLH: BaLi_c32610(ytpB)
BAY: RBAM_027520
BAQ: BACAU_2764(ytpB)
BYA: BANAU_2962(ytpB)
BAMP: B938_14195
BQY: MUS_3335
BAML: BAM5036_2685(ytpB)
BAMA: RBAU_2887(ytpB)
BAMN: BASU_2693(ytpB)
BAMB: BAPNAU_2915(ytpB)
BAMT: AJ82_15600
BAMY: V529_30320
BMP: NG74_02890(ytpB)
BAO: BAMF_2833(ytpB)
BAZ: BAMTA208_14940(ytpB)
BQL: LL3_03129
BXH: BAXH7_03062(ytpB)
BAMI: KSO_005315
BAMC: U471_28730
BAMF: U722_14850
BSIA: CWD84_05625
BAE: BATR1942_13035
BVM: B9C48_14055
BSON: S101395_01311(ytpB)
BHT: DIC78_16350
BMOJ: HC660_29140(tbcS)
BTEQ: G4P54_15465(tbcS)
BIQ: AN935_15275
BSTR: QI003_18460(tbcS)
BAN: BA_5008
BAR: GBAA_5008
BAT: BAS4653
BAH: BAMEG_5042
BAI: BAA_5021
BAX: H9401_4786
BANT: A16_50060
BANR: A16R_50700
BANS: BAPAT_4807
BANH: HYU01_24400
BANV: DJ46_3669
BCE: BC4752
BCA: BCE_4903
BCZ: BCE33L4509
BCR: BCAH187_A4894
BCB: BCB4264_A4868
BCU: BCAH820_4877
BCG: BCG9842_B0372
BCQ: BCQ_4572
BCX: BCA_4881
BAL: BACI_c47550
BNC: BCN_4666
BCF: bcf_23875
BCER: BCK_11375
BCEF: BcrFT9_03784
BCY: Bcer98_3429
BTK: BT9727_4491
BTL: BALH_4333
BTB: BMB171_C4392
BTT: HD73_5063
BTHR: YBT1520_25105
BTHI: BTK_24980
BTC: CT43_CH4779
BTF: YBT020_23435
BTM: MC28_4044
BTG: BTB_c49110(ytpB)
BTI: BTG_25090
BTN: BTF1_22320
BTHT: H175_ch4857
BTHU: YBT1518_26325
BTW: BF38_517
BTHY: AQ980_06060
BWE: BcerKBAB4_4585
BWW: bwei_0134
BMYO: BG05_1281
BTY: Btoyo_1994
BMYC: DJ92_1850
BBY: CY96_22945
BWD: CT694_25445
BTRO: FJR70_17655
BMOB: MLA2C4_24765
BNT: GSN03_22640
BPAC: LMD38_03120
BPAN: NLJ82_23330
BALU: QRY64_26745
BPU: BPUM_2682
BPUM: BW16_14470
BPUS: UP12_13720
BIF: N288_20195
BMET: BMMGA3_13540(ytpB)
BSM: BSM4216_2963
BGY: BGLY_3594(ytpB)
BWH: A9C19_04225
BXI: BK049_13625
BALT: CFN77_14405
BAER: BAE_01935
BSAF: BSL056_15120
BFD: NCTC4823_01238
BSHI: LGQ02_16210
BCAB: EFK13_15505(tbcS)
BRY: M0696_15215(tbcS)
BJS: MY9_3053
BACI: B1NLA3E_17720
GST: HW35_06145
BACW: QR42_13545
BACP: SB24_14975
BACB: OY17_17060
BACY: QF06_13440
BACL: BS34A_33160(ytpB)
BALM: BsLM_3036
BACS: AUL54_15975
BACQ: DOE78_19445
BACA: FAY30_18830
BHAI: KJK41_17300
BCAO: LC087_09325
BARD: QRY57_23430
BAEI: RE735_05980
BCO: Bcell_3320
BHK: B4U37_17380
BCOH: BC6307_17450
BCIR: C2I06_11925
NTX: NQZ71_06590
BMQ: BMQ_4856
BMD: BMD_4842
BMH: BMWSH_0391
BMEG: BG04_1846
BEO: BEH_21675
BFX: BC359_03460
PKS: IE339_20890
BHA: BH3287
BKW: BkAM31D_12285(ytpB_1) BkAM31D_19180(ytpB_2)
BCL: ABC1218
BLE: BleG1_0703
SHUA: PQ477_11985
BGI: BGM20_09205
BPF: BpOF4_04105
BON: A361_22730
BKO: CKF48_15700
CGOT: J1899_17510
CSUA: IM538_19325
CFIR: NAF01_20470
CSOA: LIS82_21510
CSPG: LS684_16730
CPSS: M5V91_26620
BDA: FSZ17_18165
OCN: CUC15_13175
OCB: CV093_13990
GKA: GK2847
GTE: GTCCBUS3UF5_32050
GTK: GT3570_13925
GTM: GT3921_05190
GLI: GLN3_06940
BCAL: CWI35_14000
GTN: GTNG_2748
GWC: GWCH70_2771
GYC: GYMC61_0661
GYA: GYMC52_2893
GCT: GC56T3_0646
GMC: GY4MC1_0748
GGH: GHH_c29230(ytpB)
GJF: M493_14730
GEA: GARCT_02875(ytpB)
GEL: IB49_06110
GSE: GT50_05780
GSR: GS3922_02025
GEJ: A0V43_12135
GZA: IC807_10395
GTH: Geoth_0816
PTL: AOT13_18540
PTB: DER53_01665
PCAL: BV455_02487(ytpB)
PARG: PspKH34_06530
AFL: Aflv_0418
AGN: AFK25_12070
ANM: GFC28_3322
AAMY: GFC30_3138
ANL: GFC29_2112
AND: GRQ40_14985
ACAI: ISX45_12455
ASED: IRT44_08730
AXL: AXY_08630
HHD: HBHAL_3850(ytpB)
HMN: HM131_07720
HLI: HLI_17535
HNZ: P9989_14325
HSAN: MUN89_09335
HSHI: MUO14_04315
HAMY: MUO15_20285
TAP: GZ22_17585
TAID: KS242_12115
VIG: BKP57_02915
VIL: CFK37_12465
VNE: CFK40_07830
VPN: A21D_02889(ytpB)
VIM: GWK91_09050
VPT: KBP50_05840
VNT: OLD84_12340
VIK: KFZ58_11910
LAO: AOX59_07300
LEX: Len3610_09210
FPN: ABE65_016005
FAR: ABE41_014820
FEC: QNH15_17935
SJE: AAV35_004115
APAK: AP3564_09595
ACOP: RI196_04870
AQT: FN924_12455
RAX: KO561_13245
BTHV: CQJ30_14215
PRD: F7984_15630
GRC: GI584_09680
GCS: MUN88_18850
GSM: MUN87_00175
RUE: DT065_08820 DT065_09020
SALE: EPH95_06640 EPH95_09130
SCIB: HUG20_16100 HUG20_16395
SCIA: HUG15_19085 HUG15_19310
POF: GS400_15430
PCHU: QNI29_16400
NMK: CHR53_21685
NTM: BTDUT50_13605
NDT: L1999_23525
NCM: QNK12_24725
NNV: QNH39_20770
MEKU: HUW50_02740
MSEM: GMB29_21425
MDG: K8L98_19655
MLIT: KDJ21_011275
AIA: AWH56_013495
BLEN: NCTC4824_03175
SEDD: ERJ70_13035
BVQ: FHE72_18510
RMF: D5E69_16830
RAZ: U9J35_18085
BCK: BCO26_2062
BAG: Bcoa_2422
BCOA: BF29_1136
BVJ: I5776_06535
CTHU: HUR95_07160
BBEV: BBEV_0732
BSE: Bsel_1232
MCUI: G8O30_10090
GAJ: MY490_03710
SLMS: MM221_03540
MJO: FOF60_19190
MSUT: LC048_03165
FHL: OE105_09105
FAF: OE104_01590
SFOR: QNH23_02125
ECTO: MUG87_09845
ALKL: MM271_20425
ALKG: MOJ78_15715
PHJ: LC071_06100
DOM: RRU94_13020
STEA: C0679_10700
PUK: PU629_05625
BBE: BBR47_09190(ytpB)
BLR: BRLA_c006780
BFM: BP422_29920
BAGR: BA6348_24165
BRW: GOP56_19310
BCHS: JNE38_04435
BCOP: JD108_18675
BPAB: PSE45_04690
BHUI: LOK74_01270
BAYD: BSPP4475_17235
BBOR: RFB14_21515
BRUM: NDK47_22430
PJD: Pjdr2_2122
GYM: GYMC10_4613
PPY: PPE_01699
PPM: PPSC2_08945(ytpB)
PPO: PPM_1702(ytpB)
PPOL: X809_09200
PPQ: PPSQR21_017770
PPOY: RE92_03355
PMS: KNP414_01594
PMQ: PM3016_1901
PMW: B2K_09645
PTA: HPL003_16960
PLV: ERIC2_c11740
PSAB: PSAB_09705
PDU: PDUR_11030
PBD: PBOR_13000
PGM: PGRAT_11915
POD: PODO_10255
PAEN: P40081_12730
PAEF: R50345_10715
PAEQ: R50912_12320
PSTE: PSTEL_11005
PAEA: R70723_11440
PAEE: R70331_11205
PAEH: H70357_12840
PAEJ: H70737_10190
PBJ: VN24_00490
PIH: UB51_14330
PRI: PRIO_2547(ytpB)
PSON: JI735_21665
PPEO: ABE82_09040
PNP: IJ22_06130
POW: IJ21_35900
PBV: AR543_10360
PXL: BS614_14075
PYG: AWM70_03975
PSWU: SY83_20680
PDH: B9T62_07480
PIB: BBD41_22360
PCX: LPB68_18450
PKB: B4V02_16360
PAIH: ASL14_02435
PVO: PVOR_24784
PLW: D5F53_07135
PLEN: EIM92_19115
PPSC: EHS13_22480
PLUT: EI981_19360
PALB: EJC50_11820
PCHI: PC41400_09965
PBK: Back11_27920
PPRT: ET464_08325
PBAC: HUB98_27060
PRZ: GZH47_06850
PLYC: GXP70_09530
PSOP: KP014_13525
PTRI: KDC22_11130
PALO: E6C60_2777
PCEL: HUB94_11085
PTJ: JRJ22_09670
PALR: HGI30_08470
PTHI: NDS46_20990
PKA: PQ456_07745
PUI: PUW25_08735
PMAH: PTQ21_15420
PDY: QJQ58_01115
PMAE: LMZ02_15715
PWN: QNH46_09525
PSPN: L1F29_09000
PPOG: QPK24_08145
PAUN: MJA45_19305
PHK: SK066_15620
PNK: AASFL403_11165
PPAB: KET34_11520
PKP: SK3146_01985(ytpB)
TCO: Theco_1421
ANX: ACH33_08190
ASOC: CB4_02881(ytpB)
ATHE: K3F53_10645
COH: EAV92_11595
COHN: KCTCHS21_19870
CCHL: FPL14_23800
CHEB: HH215_00705
SACA: FFV09_18570
PLIG: NAG76_21700
AAC: Aaci_0966
AAD: TC41_0976
AFX: JZ786_09075
AACO: K1I37_07550
ACUR: JZ785_11915
ADAU: NZD86_16455
AFAS: NZD89_21655
ACYC: JI721_10175
JEO: JMA_25300
SPAE: E2C16_07870
SURL: BI350_11760
NTR: B0W44_07175
CLB: Clo1100_0172
CTHD: CDO33_01015
CRS: FQB35_00080
CPRF: K7H06_18845
CRAS: KVH43_04800
CTH: Cthe_2097
CTX: Clo1313_2755
CCE: Ccel_0167
RHER: EHE19_001120
RPAY: P0092_00845
SWO: Swol_0969
SLP: Slip_1332
SALQ: SYNTR_1085
DSY: DSY2213
DHD: Dhaf_3343
DDH: Desde_2789
DDL: Desdi_2308
DOR: Desor_1332
DAI: Desaci_1943
DMI: Desmer_1231
DKU: Desku_3097
DAU: Daud_1265
FWA: DCMF_15630
AACX: DEACI_0427
ACAE: HYG86_16535
TMR: Tmar_0330
THEF: E1B22_05260
TCP: Q5761_01510
SAY: TPY_0399
SAP: Sulac_0364
STHR: BXT84_02820
HFV: R50_2381
CTHM: CFE_1287
GFE: Gferi_13160
TPZ: Tph_c01880
MAS: Mahau_2954
MTA: Moth_0157
MTHO: MOTHE_c01690(ytpB)
MTHZ: MOTHA_c01690(ytpB)
TOC: Toce_1521
NTH: Nther_1253
NCD: ACONDI_00735(ytpB)
SGBI: P3F81_11330
PUF: UFO1_4742
PFT: JBW_04557
MANA: MAMMFC1_01472(ytpB)
STED: SPTER_44580(ytpB)
TUR: AT726_03135
TSG: HLK68_01500
TBB: J0J69_05920
LPIL: LIP_1116
CALK: HUE98_15990
FCZ: IMF26_08795
ACIT: HPK19_22010
BALA: DSM104299_05164(ytpB)
CWO: Cwoe_1960 Cwoe_3650 Cwoe_4469 Cwoe_5620
LEN: LEP3755_50310
GLJ: GKIL_0406
NPU: Npun_F0237
TOQ: HCG51_00365
VAB: WPS_09380
 » show all
Reference
1  [PMID:21627333]
  Authors
Sato T, Yoshida S, Hoshino H, Tanno M, Nakajima M, Hoshino T
  Title
Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-beta-curcumene synthase and a tetraprenyl-beta-curcumene cyclase: identification of a new terpene cyclase.
  Journal
J Am Chem Soc 133:9734-7 (2011)
DOI:10.1021/ja203779h
  Sequence
[bsu:BSU30500]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.130
IUBMB Enzyme Nomenclature: 4.2.3.130
ExPASy - ENZYME nomenclature database: 4.2.3.130
BRENDA, the Enzyme Database: 4.2.3.130

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (472)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (450)   
   KEGG MGENES (10)   
   RefGene (11)   
Protein sequence (241)   
   UniProt (119)   
   SWISS-PROT (1)   
   RefSeq(pep) (121)   
DNA sequence (1892)   
   RefSeq(nuc) (1225)   
   GenBank (355)   
   EMBL (312)   
Protein domain (1)   
   InterPro (1)   
All databases (2611)   

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