KEGG   ENZYME: 4.2.3.136
Entry
EC 4.2.3.136                Enzyme                                 
Name
alpha-isocomene synthase;
MrTPS2
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-alpha-isocomene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate [RN:R10272]
Reaction(KEGG)
R10272
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-alpha-isocomene [CPD:C20477];
diphosphate [CPD:C00013]
Comment
Isolated from the roots of the plant Matricaria chamomilla var. recutita (chamomile). The enzyme also produced traces of five other sesquiterpenoids.
History
EC 4.2.3.136 created 2012
Orthology
K21983  alpha-isocomene synthase
Reference
1  [PMID:22682202]
  Authors
Irmisch S, Krause ST, Kunert G, Gershenzon J, Degenhardt J, Kollner TG
  Title
The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils.
  Journal
BMC Plant Biol 12:84 (2012)
DOI:10.1186/1471-2229-12-84
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.136
IUBMB Enzyme Nomenclature: 4.2.3.136
ExPASy - ENZYME nomenclature database: 4.2.3.136
BRENDA, the Enzyme Database: 4.2.3.136

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