Entry
Name
(+)-epi-alpha-bisabolol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-epi-alpha-bisabolol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate [RN:
R10274 ]
Reaction(KEGG)
Substrate
Product
(+)-epi-alpha-bisabolol [CPD:
C20479 ];
diphosphate [CPD:
C00013 ]
Comment
Isolated from the plant Phyla dulcis (Aztec sweet herb). (+)-epi-alpha-Bisabolol is the precursor of the sweetener hernandulcin.
History
EC 4.2.3.138 created 2012
Pathway
ec00909 Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K21984 (+)-epi-alpha-bisabolol synthase
Reference
Authors
Attia M, Kim SU, Ro DK
Title
Molecular cloning and characterization of (+)-epi-alpha-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.3.138