KEGG   ENZYME: 4.2.3.139
Entry
EC 4.2.3.139                Enzyme                                 
Name
valerena-4,7(11)-diene synthase;
VoTPS2;
VoTPS7
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, valerena-4,7(11)-diene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = valerena-4,7(11)-diene + diphosphate [RN:R10275]
Reaction(KEGG)
R10275
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
valerena-4,7(11)-diene [CPD:C20480];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Valeriana officinalis (valerian). Note that due to a different numbering system the product is also known as valerena-1,10-diene.
History
EC 4.2.3.139 created 2012
Orthology
K21985  valerena-4,7(11)-diene synthase
Reference
1  [PMID:22776156]
  Authors
Pyle BW, Tran HT, Pickel B, Haslam TM, Gao Z, MacNevin G, Vederas JC, Kim SU, Ro DK
  Title
Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).
  Journal
FEBS J 279:3136-46 (2012)
DOI:10.1111/j.1742-4658.2012.08692.x
  Sequence
Reference
2  [PMID:23243312]
  Authors
Yeo YS, Nybo SE, Chittiboyina AG, Weerasooriya AD, Wang YH, Gongora-Castillo E, Vaillancourt B, Buell CR, DellaPenna D, Celiz MD, Jones AD, Wurtele ES, Ransom N, Dudareva N, Shaaban KA, Tibrewal N, Chandra S, Smillie T, Khan IA, Coates RM, Watt DS, Chappell J
  Title
Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis.
  Journal
J Biol Chem 288:3163-73 (2013)
DOI:10.1074/jbc.M112.415836
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.139
IUBMB Enzyme Nomenclature: 4.2.3.139
ExPASy - ENZYME nomenclature database: 4.2.3.139
BRENDA, the Enzyme Database: 4.2.3.139

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