KEGG ENZYME: 4.2.3.39

ENZYME: 4.2.3.39

Entry

EC 4.2.3.39                 Enzyme

Name

epi-cedrol synthase;
8-epicedrol synthase;
epicedrol synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming)

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate + H2O = 8-epi-cedrol + diphosphate [RN:R09140]

Reaction(KEGG)

R09140

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]

Product

8-epi-cedrol [CPD:C18245];
diphosphate [CPD:C00013]

Comment

The enzyme is activated by Mg2+ [2]. Similar to many other plant terpenoid synthases, this enzyme produces many products from a single substrate. The predominant product is the cyclic sesquiterpenoid alcohol, 8-epi-cedrol, with minor products including cedrol and the olefins alpha-cedrene, beta-cedrene, (E)-beta-farnesene and (E)-alpha-bisabolene [1].

History

EC 4.2.3.39 created 2009

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K14176

epi-cedrol synthase

Reference

1 [PMID:10486140]