KEGG   ENZYME: 4.2.3.48
Entry
EC 4.2.3.48                 Enzyme                                 
Name
(3S,6E)-nerolidol synthase;
(E)-nerolidol synthase;
nerolidol synthase;
(3S)-(E)-nerolidol synthase;
FaNES1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3S,6E)-nerolidol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate [RN:R08374]
Reaction(KEGG)
R08374
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(3S,6E)-nerolidol [CPD:C09704];
diphosphate [CPD:C00013]
Comment
The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [2]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.
History
EC 4.2.3.48 created 2010
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14175  (3S,6E)-nerolidol synthase
Genes
CRB: 17896330
THJ: 104809526
CIT: 102617431 102617651 102617908 127899691
CIC: CICLE_v10004558mg CICLE_v10014632mg CICLE_v10014707mg
PVY: 116111381 116121150 116145960
MINC: 123192358 123192360 123192601 123192665 123192702
TCC: 108662607 18597023 18597024
GRA: 105777993
GHI: 107924963 107940942
GAB: 108452092
HSYR: 120170619 120206077
DZI: 111281010 111318783
EGR: 104431442 104445481 104447370 104447372 104447373 104447392 104447394 104447396 104447399 120293116 120294005 120294006
GMX: 100782471(TPS4) 100783015(TPS5) 100814957(TPS6)
GSJ: 114419462 114419463
PVU: PHAVU_002G219100g PHAVU_002G219300g
VRA: 106765590 106766355 106766356 106766374
VAR: 108326386 108338184 108338349
VUN: 114177509 114178712 114178713 114179677
VUM: 124848700
CCAJ: 109814060 109817871 109817878
APRC: 113858784
MTR: 25493246 25493247
TPRA: 123918156
CAM: 101494917 101495572 101503644
PSAT: 127100670 127100671 127107104
VVO: 131607540 131607542 131607544 131607546 131607547
LJA: Lj0g3v0198989.1(Lj0g3v0198989.1) Lj0g3v0198989.2(Lj0g3v0198989.2)
ADU: 107468751 107480611
AIP: 107623232 107626247
AHF: 112714726 112728647 112784898 112791359
LANG: 109334775
PCIN: 129286908 129304375 129306602 129310448
QSA: O6P43_012504 O6P43_012505 O6P43_012507 O6P43_012509 O6P43_013115
FVE: 101299453 101302321
RCN: 112165597 112166460 112202907
PPER: 18778181
PMUM: 103324596 103343969
PAVI: 110752892 110768753
PDUL: 117625092 117626312
MDM: 103434640 103446596 103446597 103446598(LIS) 114827793
MSYL: 126584635 126586071 126586072 126586073 126624473
PXB: 103941370 103941371 103958297
ZJU: 107421470 107421878
MNT: 21385024 21408693 21408694
CSAV: 115707431 115707440
CSV: 101204552 101204794 101215070
CMO: 103485748 103485753 103485759 103489227
BHJ: 120080989 120082587 120082664 120082764 120083563
MCHA: 111010706 111010875 111010876 111010887
CMAX: 111484385 111490118
CMOS: 111434067 111434068 111447175 111456834
CPEP: 111783518 111802148
RCU: 8259987
JCU: 105629808 105629819 105629820 105649410
HBR: 110635396 110644414 110654947 110661963
MESC: 110603115 110604308 110604309 110605593
POP: 18102943 7490764
PEU: 105107363 105110145
PALZ: 118031658 118031660 118031663 118042815
JRE: 108979322 108979323 108989344 109004686 109004723 109007398 109013445
CILL: 122275356 122276930 122277338 122277349 122278752 122279706 122317064 122317113
CAVE: 132170000 132171269 132171615 132171670 132171923 132172669 132172670
QSU: 111988830 111989102 111989152
QLO: 115988645 115991201 115992647 115992733
TWL: 119990104 119990105
VVI: 100244313 100266449 100267150 100852527 100852561 100852776 100853562 100853639 100854680 100854809 132252611
VRI: 117910457 117910459 117910461 117910462 117918890 117923388 117924000 117924001 117924133
SLY: 101244812(TPS37) 101245403(TPS39)
SPEN: 107019618 107032586
SOT: 102580873 102592813
SSTN: 125852752 125852754 125865371 125865396 125865910 125865911
SDUL: 129876452
CANN: 107845646 124892657
LBB: 132622398 132624607 132627926
NTA: 107828192
NTO: 104117466
NAU: 109230989
INI: 109163834 109167275 109167276 109167277 109167278 109167279
ITR: 116029121 116029228 116029229 116029230 116029231 116029232 116029233 116030387 116030506 116030578
SIND: 105156792 105175396 105175430 105175469 105175470
OEU: 111395219 111396005 111396006 111396009 111396013 111396015 111396016
EGT: 105962255 105962256
SSPL: 121759727 121783505 121787949 121794424
SMIL: 131008947 131025409
SHIS: 125209432 125212871 125216669 125217049 125219298
APAN: 127254015 127261369
HAN: 110884314 110889629 110915780 110916766 110919641
ECAD: 122597840 122599361 122608148
LSV: 111884934 111897116 111897141 111897149
CCAV: 112527638 112527948
DCR: 108194757 108195481 108195714 108195795 108195952
CSIN: 114261430 114266222 114282497 114288835 114290333
RVL: 131311333 131311341 131311347 131317236 131317238
AEW: 130752572 130752583 130752665 130753769 130760142 130760255 130774408 130774410
BVG: 104883052 104901069 104901071
SOE: 110789690 110789691
CQI: 110687149 110687263 110693359 110693461 110693462
ATRI: 130815872 130815873 130815874
MOF: 131153302 131153683
NNU: 104591086 104591099
MING: 122059466 122059660 122061859 122072008 122072223 122092317 122092318
TSS: 122638603 122639517 122667458 122667459 122668202
MUS: 103973658
ZOF: 122026772 122026775 122026776 122026778 122027395 122027544 122027662 122027819 122027865 122029243 122029247 122029248 122029250 122029976 122030942 122033495
AOF: 109820753
MSIN: 131221695 131221702
NCOL: 116246448 116246454 116247351
ATR: 18431529 18440985 18440990
 » show all
Reference
1  [PMID:15522848]
  Authors
Aharoni A, Giri AP, Verstappen FW, Bertea CM, Sevenier R, Sun Z, Jongsma MA, Schwab W, Bouwmeester HJ
  Title
Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species.
  Journal
Plant Cell 16:3110-31 (2004)
DOI:10.1105/tpc.104.023895
Reference
2  [PMID:10482672]
  Authors
Bouwmeester HJ, Verstappen FW, Posthumus MA, Dicke M
  Title
Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis.
  Journal
Plant Physiol 121:173-80 (1999)
DOI:10.1104/pp.121.1.173
Reference
3  [PMID:10805454]
  Authors
Degenhardt J, Gershenzon J
  Title
Demonstration and characterization of (E)-nerolidol synthase from maize: a herbivore-inducible terpene synthase participating in (3E)-4,8-dimethyl-1,3,7-nonatriene biosynthesis.
  Journal
Planta 210:815-22 (2000)
DOI:10.1007/s004250050684
Reference
4  [PMID:17924138]
  Authors
Arimura G, Garms S, Maffei M, Bossi S, Schulze B, Leitner M, Mithofer A, Boland W
  Title
Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of  jasmonate, ethylene and calcium signaling.
  Journal
Planta 227:453-64 (2008)
DOI:10.1007/s00425-007-0631-y
  Sequence
[mtr:25493246]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.48
IUBMB Enzyme Nomenclature: 4.2.3.48
ExPASy - ENZYME nomenclature database: 4.2.3.48
BRENDA, the Enzyme Database: 4.2.3.48

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (388)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (381)   
   KEGG MGENES (2)   
   RefGene (4)   
Protein sequence (23)   
   UniProt (18)   
   SWISS-PROT (5)   
DNA sequence (9)   
   GenBank (5)   
   EMBL (4)   
Protein domain (9)   
   InterPro (9)   
All databases (437)   

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