KEGG   ENZYME: 4.2.3.56
Entry
EC 4.2.3.56                 Enzyme                                 
Name
gamma-humulene synthase;
humulene cyclase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (gamma-humulene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = gamma-humulene + diphosphate [RN:R08540]
Reaction(KEGG)
R08540
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
gamma-humulene [CPD:C16829];
diphosphate [CPD:C00013]
History
EC 4.2.3.56 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14186  gamma-humulene synthase
Reference
1  [PMID:9442047]
  Authors
Steele CL, Crock J, Bohlmann J, Croteau R
  Title
Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase.
  Journal
J Biol Chem 273:2078-89 (1998)
DOI:10.1074/jbc.273.4.2078
  Sequence
Reference
2  [PMID:12051690]
  Authors
Little DB, Croteau RB
  Title
Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase.
  Journal
Arch Biochem Biophys 402:120-35 (2002)
DOI:10.1016/S0003-9861(02)00068-1
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.56
IUBMB Enzyme Nomenclature: 4.2.3.56
ExPASy - ENZYME nomenclature database: 4.2.3.56
BRENDA, the Enzyme Database: 4.2.3.56
CAS: 110639-19-5

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