Entry
Name
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = patchoulol + diphosphate [RN:
R09629 ]
Reaction(KEGG)
Substrate
Product
History
EC 4.2.3.70 created 2011
Pathway
ec00909 Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15807 patchoulol/alpha-guaiene/delta-guaiene synthase
Reference
Authors
Croteau R, Munck SL, Akoh CC, Fisk HJ, Satterwhite DM
Title
Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations.
Journal
Sequence
Reference
Authors
Munck SL, Croteau R
Title
Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin.
Journal
Sequence
Reference
Authors
Faraldos JA, Wu S, Chappell J, Coates RM
Title
Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.70
ExPASy - ENZYME nomenclature database: 4.2.3.70