KEGG   ENZYME: 4.2.3.74
Entry
EC 4.2.3.74                 Enzyme                                 
Name
presilphiperfolanol synthase;
BcBOT2;
CND15
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphohydrolase (presilphiperfolan-8beta-ol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = presilphiperfolan-8beta-ol + diphosphate [RN:R09630]
Reaction(KEGG)
R09630
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
presilphiperfolan-8beta-ol [CPD:C19756];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Presilphiperfolan-8beta-ol is the precursor of botrydial, a phytotoxic sesquiterpene metabolite secreted by the fungus Botryotinia fuckeliana (Botrytis cinerea), the causal agent of gray mold disease in plants.
History
EC 4.2.3.74 created 2011
Orthology
K22056  presilphiperfolanol synthase
Reference
1  [PMID:19035644]
  Authors
Pinedo C, Wang CM, Pradier JM, Dalmais B, Choquer M, Le Pecheur P, Morgant G, Collado IG, Cane DE, Viaud M
  Title
Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea.
  Journal
ACS Chem Biol 3:791-801 (2008)
DOI:10.1021/cb800225v
  Sequence
[ag:AAQ16575]
Reference
2  [PMID:19476353]
  Authors
Wang CM, Hopson R, Lin X, Cane DE
  Title
Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol.
  Journal
J Am Chem Soc 131:8360-1 (2009)
DOI:10.1021/ja9021649
  Sequence
[ag:AAQ16575]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.74
IUBMB Enzyme Nomenclature: 4.2.3.74
ExPASy - ENZYME nomenclature database: 4.2.3.74
BRENDA, the Enzyme Database: 4.2.3.74

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   PDBSTR (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   InterPro (3)   
All databases (23)   

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