KEGG ENZYME: 4.2.3.76

ENZYME: 4.2.3.76

Entry

EC 4.2.3.76                 Enzyme

Name

(+)-delta-selinene synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-delta-selinene-forming]

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate [RN:R09616]

Reaction(KEGG)

R09616

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

(+)-delta-selinene [CPD:C19742];
diphosphate [CPD:C00013]

Comment

Initial cyclization gives germacrene C in an enzyme bound form which is not released to the medium.

History

EC 4.2.3.76 created 2011

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

Orthology

K15806

(+)-delta-selinene synthase

Reference

1 [PMID:9442047]

Authors

Steele CL, Crock J, Bohlmann J, Croteau R

Title

Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase.

Journal

J Biol Chem 273:2078-89 (1998)
DOI:10.1074/jbc.273.4.2078

Sequence

[ag:AAC05727]

Reference

2 [PMID:12051690]

Authors

Little DB, Croteau RB

Title

Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase.

Journal

Arch Biochem Biophys 402:120-35 (2002)
DOI:10.1016/S0003-9861(02)00068-1

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.76

IUBMB Enzyme Nomenclature:

4.2.3.76

ExPASy - ENZYME nomenclature database:

4.2.3.76

BRENDA, the Enzyme Database:

4.2.3.76

DBGET integrated database retrieval system