Entry
Name
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl diphosphate lyase (cyclizing, (+)-thujopsene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate [RN:
R10599 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ]
Product
Comment
The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% (+)-alpha-barbatene, 17.8% (+)-thujopsene and 9.9% (+)-beta-chamigrene [1] plus traces of other sesquiterpenoids [2]. See EC
4.2.3.69 (+)-alpha-barbatene synthase, and EC
4.2.3.78 beta-chamigrene synthase.
History
EC 4.2.3.79 created 2011
Pathway
ec00909 Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15799 (+)-alpha-barbatene/beta-chamigrene/thujopsene synthase
Genes
CRB : 17875170 17875197 17876640
EUS : EUTSA_v10001108mg EUTSA_v10001148mg EUTSA_v10001228mg
BRP : 103845828 103848456 103863851
RSZ : 108809961 108835137 108851518
Taxonomy
Reference
Authors
Wu S, Schoenbeck MA, Greenhagen BT, Takahashi S, Lee S, Coates RM, Chappell J
Title
Surrogate splicing for functional analysis of sesquiterpene synthase genes.
Journal
Sequence
Reference
Authors
Tholl D, Chen F, Petri J, Gershenzon J, Pichersky E
Title
Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from Arabidopsis flowers.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.79
ExPASy - ENZYME nomenclature database: 4.2.3.79